N. Apanovich, V. I. Loginov, E. Filippova, D. S. Khodyrev, A. Burdennyy, I. Pronina, N. Ivanova, S. Lukina, T. Kazubskaya, V. Matveev, A. Karpukhin, E. Braga
{"title":"Methylation of a group of microRNA genes: markers of renal cell carcinoma metastasis","authors":"N. Apanovich, V. I. Loginov, E. Filippova, D. S. Khodyrev, A. Burdennyy, I. Pronina, N. Ivanova, S. Lukina, T. Kazubskaya, V. Matveev, A. Karpukhin, E. Braga","doi":"10.17650/1726-9776-2020-16-4-32-38","DOIUrl":null,"url":null,"abstract":"methylation late (III–IV) of metastasis lymph nodes These 4 genes used to a potential metastatic prognosis system with a clinical sensitivity of 68 % and a specificity of 84 % (area under curve 0.83), which will be applied in the final development of a system for personalized therapy of RCC patients. Conclusion. The association of methylation of the MIR1258 with RCC metastasis has been shown for the first time and is of independent inter-est as a new promising marker for the prognosis of metastatic relapses.","PeriodicalId":42924,"journal":{"name":"Onkourologiya","volume":"1 1","pages":""},"PeriodicalIF":0.1000,"publicationDate":"2021-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Onkourologiya","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.17650/1726-9776-2020-16-4-32-38","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"ONCOLOGY","Score":null,"Total":0}
引用次数: 1
Abstract
methylation late (III–IV) of metastasis lymph nodes These 4 genes used to a potential metastatic prognosis system with a clinical sensitivity of 68 % and a specificity of 84 % (area under curve 0.83), which will be applied in the final development of a system for personalized therapy of RCC patients. Conclusion. The association of methylation of the MIR1258 with RCC metastasis has been shown for the first time and is of independent inter-est as a new promising marker for the prognosis of metastatic relapses.
期刊介绍：
The main objective of the journal "Cancer urology" is publishing up-to-date information about scientific clinical researches, diagnostics, treatment of oncologic urological diseases. The aim of the edition is to inform the experts on oncologic urology about achievements in this area, to build understanding of the necessary integrated interdisciplinary approach in therapy, alongside with urologists, combining efforts of doctors of various specialties (cardiologists, pediatricians, chemotherapeutists et al.), to contribute to raising the effectiveness of oncologic patients’ treatment.
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