MOLECULAR, NEUROPHYSIOLOGICAL AND INTEGRATIVE EFFECTS OF THE COMBINED EXPOSURE TO TAIL-SUSPENSION AND IONIZING RADIATION IN RATS

Q4 Biochemistry, Genetics and Molecular Biology Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine Pub Date : 2022-01-01 DOI:10.21687/0233-528x-2022-56-2-30-38

K. Lebedeva-Georgievskaya, A. Perevezentsev, O. Kuznetsova, V. Kudrin, V. Pikalov, O. Mitrofanova, A. A. Masanova, A. Shtemberg

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Abstract

Molecular mechanisms of the neurobiological effects of 10-d suspension combined with daily exposure to ᵞ-radiation and carbon ions were studied in rats. Analysis of the molecular changes in hippocamp dopamine receptors revealed changes in irradiated rats including, specifically, intensive expression of monoamine oxidase А, substrates for which are serotonin, adrenalin, noradrenaline and histamine. The EEG spectral and amplitude-frequency characteristics were analyzed. Comparison of primary EEG data regardless of rhythms brought to light a downward trend in the alpha frequencies. A similar trend was observed in the center frequencies and amplitudes of the most expressed peak, and the center frequency and amplitude of the delta highest peak. More anxious behavior and a somewhat quicker learning to fulfill the Morris tests and conditioned response of active avoidance in the shuttle chamber were in harmony with changes in metabolites of hippocamp dopamine and serotonin.

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尾悬液和电离辐射联合暴露对大鼠的分子、神经生理和综合影响

研究了10 d悬液联合ᵞ-辐射和碳离子对大鼠神经生物学效应的分子机制。对海马多巴胺受体分子变化的分析揭示了辐照大鼠的变化，特别是单胺氧化酶А的强烈表达，其底物是5 -羟色胺、肾上腺素、去甲肾上腺素和组胺。分析了脑电信号的频谱和幅频特性。不考虑节律的初级脑电图数据的比较揭示了α频率的下降趋势。在表达最多的峰的中心频率和幅值以及δ峰值的中心频率和幅值中也观察到类似的趋势。更多的焦虑行为和更快地学习完成莫里斯测试，以及在穿梭室中主动回避的条件反应，与海马多巴胺和血清素代谢物的变化是一致的。

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Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)

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