{"title":"ACTION OF TWO NEW NICOTINIC ACID DERIVATIVES ON THE LEVEL OF HIPPOCAMPUS IN RATS","authors":"V. Yasnetsov, Y. Ivanov, V. Yasnetsov","doi":"10.21687/0233-528x-2023-57-2-74-77","DOIUrl":null,"url":null,"abstract":"Experiments on hippocampal slices in rats showed that new nicotinic acid derivatives LKhT 6-20 and LKhT 7-20 at 5 mM inhibited the СА1 orthodromic population responses by 43 4 and 69 5%, respectively, whereas preparation of comparison mexicor in equal concentration inhibited the responses by 52 4 %. Action of LKhT 7-20 exceeded LKhT6–20 in 1.6 times and mexicor, in 1.3 times. The refore, LKhT 6-20 and LKhT 7-20 inhibit synaptic transmission between Schaffer collaterals and pyramidal СА1 neurons. It can be inferred that hippocampus has a significant role in the central action of these new substances.","PeriodicalId":8683,"journal":{"name":"Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.21687/0233-528x-2023-57-2-74-77","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Biochemistry, Genetics and Molecular Biology","Score":null,"Total":0}
引用次数: 0
Abstract
Experiments on hippocampal slices in rats showed that new nicotinic acid derivatives LKhT 6-20 and LKhT 7-20 at 5 mM inhibited the СА1 orthodromic population responses by 43 4 and 69 5%, respectively, whereas preparation of comparison mexicor in equal concentration inhibited the responses by 52 4 %. Action of LKhT 7-20 exceeded LKhT6–20 in 1.6 times and mexicor, in 1.3 times. The refore, LKhT 6-20 and LKhT 7-20 inhibit synaptic transmission between Schaffer collaterals and pyramidal СА1 neurons. It can be inferred that hippocampus has a significant role in the central action of these new substances.
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