Pub Date : 2023-01-01DOI: 10.21687/0233-528x-2023-57-1-5-20
A. Grigoriev, O. Orlov, A. Potapov
The review emphasizes that native space medicine will be focused on biological, physiological and psychological aspects of the human being in light of preparation for next milestones in space exploration. The current knowledge and expertise serve as a solid ground for new concepts and technologies that will safeguard humans against risks and events they will inevitably encounter in an unfamiliar world.
{"title":"ROLE OF THE NATIVE SPACE MEDICINE AND PHYSIOLOGY IN EXPLORATION OF OUTER SPACE","authors":"A. Grigoriev, O. Orlov, A. Potapov","doi":"10.21687/0233-528x-2023-57-1-5-20","DOIUrl":"https://doi.org/10.21687/0233-528x-2023-57-1-5-20","url":null,"abstract":"The review emphasizes that native space medicine will be focused on biological, physiological and psychological aspects of the human being in light of preparation for next milestones in space exploration. The current knowledge and expertise serve as a solid ground for new concepts and technologies that will safeguard humans against risks and events they will inevitably encounter in an unfamiliar world.","PeriodicalId":8683,"journal":{"name":"Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67958875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.21687/0233-528x-2023-57-1-82-85
In experiments with mice under various models of acute hypoxia a new synthesized compound LKhT 3-21 (50 mg/kg) showed a distinct antihypoxic activity. In comparison to mexicor (50 mg/kg), this compound increased lifespan in a hermetic chamber, under hemic hypoxia and histotoxic hypoxia by 107 %, 47 %, and 70 %, respectively. LKhT 3-21 exceeded mexicor in the effect against acute normobaric hypoxia with hypercapnia (in 1.9 times), acute hemic hypoxia (in 1.4 times) and acute histotoxic hypoxia (in 1.6 times).
{"title":"INVESTIGATIONS OF THE ANTIHYPOXIC ACTIVITY OF NEW COMPOUND LKHT 3-21 IN EXPERIMENTS WITH ANIMALS","authors":"","doi":"10.21687/0233-528x-2023-57-1-82-85","DOIUrl":"https://doi.org/10.21687/0233-528x-2023-57-1-82-85","url":null,"abstract":"In experiments with mice under various models of acute hypoxia a new synthesized compound LKhT 3-21 (50 mg/kg) showed a distinct antihypoxic activity. In comparison to mexicor (50 mg/kg), this compound increased lifespan in a hermetic chamber, under hemic hypoxia and histotoxic hypoxia by 107 %, 47 %, and 70 %, respectively. LKhT 3-21 exceeded mexicor in the effect against acute normobaric hypoxia with hypercapnia (in 1.9 times), acute hemic hypoxia (in 1.4 times) and acute histotoxic hypoxia (in 1.6 times).","PeriodicalId":8683,"journal":{"name":"Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67958892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.21687/0233-528x-2023-57-2-39-46
D.V. Pashkova, Yu. A. Popova, А.А. Fedorovich
Functional state of skin microcirculation vessels was studied in female subjects during 3-d dry immersion (DI). Microcirculation was investigated on the forehead, shin, forearm, fingers and toes with the use of laser Doppler flowmetry (LDF) and computer based video capillaroscopy. LDF showed that DI induced local changes in the level of perfusion, largely due to an increased myogenic control of the microvascular tone. Video capillaroscopy detected an upward trend in the number of functioning capillaries after DI; dimensions of the pericapillary zone remained unchanged.
{"title":"FUNCTIONAL STATE OF THE SKIN MICROCIRCULATION BED IN HEALTHY FEMALES IN THE CONDITION OF DRY IMMERSION","authors":"D.V. Pashkova, Yu. A. Popova, А.А. Fedorovich","doi":"10.21687/0233-528x-2023-57-2-39-46","DOIUrl":"https://doi.org/10.21687/0233-528x-2023-57-2-39-46","url":null,"abstract":"Functional state of skin microcirculation vessels was studied in female subjects during 3-d dry immersion (DI). Microcirculation was investigated on the forehead, shin, forearm, fingers and toes with the use of laser Doppler flowmetry (LDF) and computer based video capillaroscopy. LDF showed that DI induced local changes in the level of perfusion, largely due to an increased myogenic control of the microvascular tone. Video capillaroscopy detected an upward trend in the number of functioning capillaries after DI; dimensions of the pericapillary zone remained unchanged.","PeriodicalId":8683,"journal":{"name":"Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67958951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.21687/0233-528x-2023-57-2-5-13
А. Artamonov, D. Molodtsova, T.A. Smirnova, N. Konstantinova
Scientific publications were used to undertake systematic analysis of the effects of electromagnetic radiation (EMR) on heat shock gene expression in various bio-objects. International normative documents assume that high intensity EMR (100 µWatt/cm2) causes expression of the heat shock gene and ensuing biological consequences. In Russia, the flux energy data level is taken to be 10 µWatt/cm2. Term "data level" means that the EMR bio-effect is not thermal by nature. However, Russian national standard GOST R 50804-95 containing the general medical-engineering requirements to cosmonaut's environment in a piloted spacecraft sets the maximum admissible level at 1000 µWatt/cm2 within the EMR band of 0.3–300 GHz. Systematic analysis of the EMR effects within this band did not reveal expression of the heat shock gene. The investigation should be proceeded with the focus on the EMR non-heat bio-effects.
利用科学出版物对电磁辐射(EMR)对各种生物体内热休克基因表达的影响进行了系统的分析。国际规范性文件假设高强度EMR(100µWatt/cm2)会导致热休克基因的表达和随之而来的生物后果。在俄罗斯，通量能量数据水平为10µWatt/cm2。术语“数据级”是指EMR生物效应本质上不是热效应。但是，俄罗斯国家标准GOST R 50804-95载有对载人航天器中宇航员环境的一般医疗工程要求，将0.3-300 GHz EMR频段内的最大允许电平定为1000µWatt/cm2。系统分析该波段的EMR效应并没有揭示热休克基因的表达。研究应重点关注EMR的非热生物效应。
{"title":"SYSTEMATIC ANALYSIS OF THE ELECTROMAGNETIC RADIATION EFFECT ON EXPRESSION OF THE HEAT SHOCK GENE WITH REGARD TO THE GOALS OF SPACE MEDICINE","authors":"А. Artamonov, D. Molodtsova, T.A. Smirnova, N. Konstantinova","doi":"10.21687/0233-528x-2023-57-2-5-13","DOIUrl":"https://doi.org/10.21687/0233-528x-2023-57-2-5-13","url":null,"abstract":"Scientific publications were used to undertake systematic analysis of the effects of electromagnetic radiation (EMR) on heat shock gene expression in various bio-objects. International normative documents assume that high intensity EMR (100 µWatt/cm2) causes expression of the heat shock gene and ensuing biological consequences. In Russia, the flux energy data level is taken to be 10 µWatt/cm2. Term \"data level\" means that the EMR bio-effect is not thermal by nature. However, Russian national standard GOST R 50804-95 containing the general medical-engineering requirements to cosmonaut's environment in a piloted spacecraft sets the maximum admissible level at 1000 µWatt/cm2 within the EMR band of 0.3–300 GHz. Systematic analysis of the EMR effects within this band did not reveal expression of the heat shock gene. The investigation should be proceeded with the focus on the EMR non-heat bio-effects.","PeriodicalId":8683,"journal":{"name":"Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67958973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.21687/0233-528x-2023-57-3-65-76
Е.А. Deshevaya, V. Beliaev, V. Bychkov, A.V. Peklevsky, S. Poddubko, E. Shubralova, I. B. Rabaev
The authors present 4-component research equipment BAR and results of monitoring the internal climatic factors in the ISS Russian segment, i.e. temperature, humidity and airstreams, and images of corroded shell sections. The authors dwell on the presence of microbial contaminants and associated climatic parameters, and further developments in the transfer module since 2020 when shell defects were detected. It was concluded that corrosion and bacterial and fungal colonies could have emerged as in the zones of conceivable moisture condensation with surface temperatures below the dew point, so, unpredictably, in zones with higher temperatures. It is imperative to proceed dynamic monitoring of corroded zones and check for possible leakage of window sealants.
{"title":"EXPERIENCE OF USING RESEARCH EQUIPMENT «BAR» TO MONITOR THE ISS CLIMATIC FACTORS IN THE INTEREST OF CONTROLLING MODULES HERMETICITY","authors":"Е.А. Deshevaya, V. Beliaev, V. Bychkov, A.V. Peklevsky, S. Poddubko, E. Shubralova, I. B. Rabaev","doi":"10.21687/0233-528x-2023-57-3-65-76","DOIUrl":"https://doi.org/10.21687/0233-528x-2023-57-3-65-76","url":null,"abstract":"The authors present 4-component research equipment BAR and results of monitoring the internal climatic factors in the ISS Russian segment, i.e. temperature, humidity and airstreams, and images of corroded shell sections. The authors dwell on the presence of microbial contaminants and associated climatic parameters, and further developments in the transfer module since 2020 when shell defects were detected. It was concluded that corrosion and bacterial and fungal colonies could have emerged as in the zones of conceivable moisture condensation with surface temperatures below the dew point, so, unpredictably, in zones with higher temperatures. It is imperative to proceed dynamic monitoring of corroded zones and check for possible leakage of window sealants.","PeriodicalId":8683,"journal":{"name":"Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67959944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
We studied the effects on the human system of plasma hemostasis of sequel rotations on a short-arm centrifuge with equal absolute g value and direction. Participants were 6 normal male volunteers at the age of 25 to 45 years. The volunteers were rotated 7 times in the head-to-pelvis direction (+Gz) at 2.1 g. The first rotation was performed prior to the series; the series of 5 rotations was performed with a 2-day interval between each; the final rotation was performed in 14 days after the series. Citrated plasma was used to investigate the procoagulent component of homeostasis, physiological anticoagulents, and intensity of fibrin formation and fibrinolysis. As compared to baseline data, fibrinogen concentration was increased significantly by 4 % on day 7 post rotations; thrombin time was found decreased by 5 % prior to the 6th rotation. Protein C activity was reduced significantly after rotations 3 and 5 by 8 % and 9 %, respectively. Antithrombin III was reduced by 4 % after rotation 5. Concentration of D-dimer was increased after rotations 5 and 6 by 87 % and 32 %, respectively. Rotations produced minor changes in the levels of pro- and anticoagulents, and also in the intensity of fibrin formation and fibrinolysis, that is these changes were within the physiological norm and reflected adaptive processes in organism.
{"title":"PLASMA COMPONENT IN THE HEMOSTASIS SYSTEM OF VOLUNTEERS FOR THE EXPERIMENT WITH A SERIES PROPHYLACTIC ROTATION ON A SHORT-ARM CENTRIFUGE","authors":"A.Yu. Kocherguin, А.А. Markin, О.А. Zhuravleva, M.I. Koloteva, O.I. Labetskaya, T.V. Zhuravleva, Т.А. Smirnova, D.S. Kuzichkin, A.L. Vorontsov, G.A. Tikhonova","doi":"10.21687/0233-528x-2023-57-4-26-30","DOIUrl":"https://doi.org/10.21687/0233-528x-2023-57-4-26-30","url":null,"abstract":"We studied the effects on the human system of plasma hemostasis of sequel rotations on a short-arm centrifuge with equal absolute g value and direction. Participants were 6 normal male volunteers at the age of 25 to 45 years. The volunteers were rotated 7 times in the head-to-pelvis direction (+Gz) at 2.1 g. The first rotation was performed prior to the series; the series of 5 rotations was performed with a 2-day interval between each; the final rotation was performed in 14 days after the series. Citrated plasma was used to investigate the procoagulent component of homeostasis, physiological anticoagulents, and intensity of fibrin formation and fibrinolysis. As compared to baseline data, fibrinogen concentration was increased significantly by 4 % on day 7 post rotations; thrombin time was found decreased by 5 % prior to the 6th rotation. Protein C activity was reduced significantly after rotations 3 and 5 by 8 % and 9 %, respectively. Antithrombin III was reduced by 4 % after rotation 5. Concentration of D-dimer was increased after rotations 5 and 6 by 87 % and 32 %, respectively. Rotations produced minor changes in the levels of pro- and anticoagulents, and also in the intensity of fibrin formation and fibrinolysis, that is these changes were within the physiological norm and reflected adaptive processes in organism.","PeriodicalId":8683,"journal":{"name":"Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135800930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.21687/0233-528x-2023-57-1-29-33
A. S. Sheblaeva, Z. Solovieva, I. Rukavishnikov, A. M. Nosovsky, V. Tsarev, M. Podporin, O.V. Bystrova, S. M. Lovtsevich, V. Ilyin
The paper deals with comparative investigation of the conventional bacteriological method (CBM) and a relatively new technique of microbial markers determination by mass-spectrometry (MS-MMs) from the standpoint of microbiological monitoring of the parodentium and other oropharyngeal surfaces. Data of the investigation performed with participation of human subjects in a 7-d dry immersion study brought to light the strong and weak points of each approach and demonstrated MS-MMseffectiveness in quantitative assessment of periodontal pathogens and oral microbiome.
{"title":"COMPARISON OF THE BACTERIOLOGICAL METHOD AND MASS-SPECTROMETRY OF MICROBIAL MARKERS FOR QUANTITATIVE ESTIMATION OF HUMAN PARODENTIUM MICROBIOTA IN A DRY IMMERSION STUDY","authors":"A. S. Sheblaeva, Z. Solovieva, I. Rukavishnikov, A. M. Nosovsky, V. Tsarev, M. Podporin, O.V. Bystrova, S. M. Lovtsevich, V. Ilyin","doi":"10.21687/0233-528x-2023-57-1-29-33","DOIUrl":"https://doi.org/10.21687/0233-528x-2023-57-1-29-33","url":null,"abstract":"The paper deals with comparative investigation of the conventional bacteriological method (CBM) and a relatively new technique of microbial markers determination by mass-spectrometry (MS-MMs) from the standpoint of microbiological monitoring of the parodentium and other oropharyngeal surfaces. Data of the investigation performed with participation of human subjects in a 7-d dry immersion study brought to light the strong and weak points of each approach and demonstrated MS-MMseffectiveness in quantitative assessment of periodontal pathogens and oral microbiome.","PeriodicalId":8683,"journal":{"name":"Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67957383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.21687/0233-528x-2023-57-3-85-88
V. Shurshakov, E. V. Belov, Е.А. Ilyin, К.О. Inozemtsev, D. Molodtsova, N. Konstantinova, А. Artamonov
The electromagnetic background was measured in living quarters of station «Vostok» located on the Antarctic plateau distant from potential sources of technogenic electromagnetic fields. Level of E-radiation in the range from 0.8 to 8 GHz was determined using integral dosimeter MERA. Based on the results of long-term continuous (one to 4 months) measurements, the mean flux density was equal to 1.5 ± 0.8 nwatts/cm2 that is nearly 7 000 times lower than the admissible level for population adopted in Russia. Antarctic station «Vostok» can be considered as a plausible location of biomedical investigations into the effects of low-frequency electromagnetic radiation.
{"title":"STUDIES OF THE ELECTROMAGNETIC BACKGROUND ON ANTARCTIC STATION «VOSTOK»","authors":"V. Shurshakov, E. V. Belov, Е.А. Ilyin, К.О. Inozemtsev, D. Molodtsova, N. Konstantinova, А. Artamonov","doi":"10.21687/0233-528x-2023-57-3-85-88","DOIUrl":"https://doi.org/10.21687/0233-528x-2023-57-3-85-88","url":null,"abstract":"The electromagnetic background was measured in living quarters of station «Vostok» located on the Antarctic plateau distant from potential sources of technogenic electromagnetic fields. Level of E-radiation in the range from 0.8 to 8 GHz was determined using integral dosimeter MERA. Based on the results of long-term continuous (one to 4 months) measurements, the mean flux density was equal to 1.5 ± 0.8 nwatts/cm2 that is nearly 7 000 times lower than the admissible level for population adopted in Russia. Antarctic station «Vostok» can be considered as a plausible location of biomedical investigations into the effects of low-frequency electromagnetic radiation.","PeriodicalId":8683,"journal":{"name":"Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67960109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.21687/0233-528x-2023-57-2-14-19
O. Orlov, I. I. Popova, Yu.G. Reviakin
The paper describes the telemedicine methods of video info acquisition from cosmonauts in the ISS RS using the available hard- and software for ENT, periodentium and teeth imaging and full examination in the course of mission, after extravehicular activities or dynamic flight stages, as well as in the pre-launch and post-landing periods within the program of space experiment LOR. Also, the paper presents the results of computerized examination and tele-imaging of the upper airways tunica mucosa, pariodentium, tooth crown, auricle and middle ear.
{"title":"UPGRADING METHODOLOGY AND HARD- AND SOFTWARE FOR OBTAINING TELEMEDICINE VIDEO INFORMATION IN SPACE FLIGHTS","authors":"O. Orlov, I. I. Popova, Yu.G. Reviakin","doi":"10.21687/0233-528x-2023-57-2-14-19","DOIUrl":"https://doi.org/10.21687/0233-528x-2023-57-2-14-19","url":null,"abstract":"The paper describes the telemedicine methods of video info acquisition from cosmonauts in the ISS RS using the available hard- and software for ENT, periodentium and teeth imaging and full examination in the course of mission, after extravehicular activities or dynamic flight stages, as well as in the pre-launch and post-landing periods within the program of space experiment LOR. Also, the paper presents the results of computerized examination and tele-imaging of the upper airways tunica mucosa, pariodentium, tooth crown, auricle and middle ear.","PeriodicalId":8683,"journal":{"name":"Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67958896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.21687/0233-528x-2023-57-2-27-32
G. Fomina, A. Salnikov, M. I. Koloteva, T. M. Glebova, К.А. Lobanov
We investigated peripheral arterial blood flow during exposure to the head-to-legs g-loads (+Gz) on a short-arm centrifuge (SAC). Purpose was to use some objective monitoring instruments for testing the hypothesis that the hemodynamic reaction to +Gz would be analogous to the reactions observed in the tilt test and/or the lower body negative pressure (LBNP) test. Six normal male subjects participated in 6 SAC runs with alternating interval g-loads of +1.27 Gz and +2.7 Gz. Blood flow in the femoral (FA) and medial cerebral (MCA) arteries was recorded continuously before, during and after runs with the use of Doppler flowmetry (Kardiomed device). It was found that +Gz centrifugation produced typical anti-gravity changes in hemodynamics, i.e. an increase in FA resistance and decrease in MCR resistance. In comparison to the records at rest, FA blood flow decreased 60 %; MCA blood flow changed insignificantly - no more than 10 % down. It was borne out that +Gz centrifugation has same effects as the Earth's gravity in standing humans, produces orthostatic blood pressure in the lower part of the body, and initiates the totality of anti-gravity hemodynamic reactions. Doppler recording was a quite useful source of data about the blood flow reaction to +Gz centrifugation.
{"title":"EVALUATION OF THE PERIPHERAL HEMODYNAMICS REACTION TO G-LOADS IN THE HEAD-TO-LEGS DIRECTION (+Gz) ON A SHORT-ARM CENTRIFUGE WITH THE METHOD OF DOPPLER FLOWMETRY","authors":"G. Fomina, A. Salnikov, M. I. Koloteva, T. M. Glebova, К.А. Lobanov","doi":"10.21687/0233-528x-2023-57-2-27-32","DOIUrl":"https://doi.org/10.21687/0233-528x-2023-57-2-27-32","url":null,"abstract":"We investigated peripheral arterial blood flow during exposure to the head-to-legs g-loads (+Gz) on a short-arm centrifuge (SAC). Purpose was to use some objective monitoring instruments for testing the hypothesis that the hemodynamic reaction to +Gz would be analogous to the reactions observed in the tilt test and/or the lower body negative pressure (LBNP) test. Six normal male subjects participated in 6 SAC runs with alternating interval g-loads of +1.27 Gz and +2.7 Gz. Blood flow in the femoral (FA) and medial cerebral (MCA) arteries was recorded continuously before, during and after runs with the use of Doppler flowmetry (Kardiomed device). It was found that +Gz centrifugation produced typical anti-gravity changes in hemodynamics, i.e. an increase in FA resistance and decrease in MCR resistance. In comparison to the records at rest, FA blood flow decreased 60 %; MCA blood flow changed insignificantly - no more than 10 % down. It was borne out that +Gz centrifugation has same effects as the Earth's gravity in standing humans, produces orthostatic blood pressure in the lower part of the body, and initiates the totality of anti-gravity hemodynamic reactions. Doppler recording was a quite useful source of data about the blood flow reaction to +Gz centrifugation.","PeriodicalId":8683,"journal":{"name":"Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67958937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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