T. M. Bychkova, O. Nikitenko, D. Utina, А.А. Ivanov
{"title":"EFFECT OF LONG-TERM FRACTIONATED ϒ-IRRADIATION ON MICE LIFESPAN","authors":"T. M. Bychkova, O. Nikitenko, D. Utina, А.А. Ivanov","doi":"10.21687/0233-528x-2022-56-4-77-82","DOIUrl":null,"url":null,"abstract":"The bio-effect of long-term fractionated γ-irradiation with a low total dose was assessed by the criteria of lifespan and death rate in certain life periods. The experiment was made with 40 female ICR (CD-1) mice. Fractionated irradiation of the animals with γ-quants 60Co (50 mGy×33 wks) brought about reduction of the mice mean life by more than 150 days. The total dose of 1.65 Gy is approximate to the admissible career dose limit for cosmonauts. Untimely deaths, in comparison with the control mice, were observed both in the early and terminal periods. Also, body mass of the irradiated animals was increased throughout the follow-up time. The data can be used for evaluation of the risks of tumor and cardiovascular diseases from chronic irradiation of crews during long-term exploration missions.","PeriodicalId":8683,"journal":{"name":"Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.21687/0233-528x-2022-56-4-77-82","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Biochemistry, Genetics and Molecular Biology","Score":null,"Total":0}
引用次数: 0
Abstract
The bio-effect of long-term fractionated γ-irradiation with a low total dose was assessed by the criteria of lifespan and death rate in certain life periods. The experiment was made with 40 female ICR (CD-1) mice. Fractionated irradiation of the animals with γ-quants 60Co (50 mGy×33 wks) brought about reduction of the mice mean life by more than 150 days. The total dose of 1.65 Gy is approximate to the admissible career dose limit for cosmonauts. Untimely deaths, in comparison with the control mice, were observed both in the early and terminal periods. Also, body mass of the irradiated animals was increased throughout the follow-up time. The data can be used for evaluation of the risks of tumor and cardiovascular diseases from chronic irradiation of crews during long-term exploration missions.
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