Molecular background of the merle coat color in dogs and its health consequences

IF 0.4 4区农林科学 Q4 VETERINARY SCIENCES Medycyna Weterynaryjna-Veterinary Medicine-Science and Practice Pub Date : 2023-01-01 DOI:10.21521/mw.6769

I. Szatkowska, Martyna Otręba, J. Korbecki, E. Czerniawska-Piątkowska, J. Wójcik, W. Grzesiak, D. Zaborski

引用次数: 0

Abstract

Coat colour in dogs is influenced by many genes and their polymorphic forms. The main coat colour pattern depends on pigment type, i.e. eumelanin or pheomelanin, whose synthesis is regulated by tyrosinase encoded by the TYRP1 gene. However, other genes also contribute to the ultimate phenotype. One of them is PMEL responsible for the merle coat colour. This review focuses on the role of melanocytes in the phenotypic expression of coat colour, the merle phenotype and genotype, phenotypic diversity of the M allele carriers, health consequences for the carriers of the allele responsible for the merle coat colour and problems with the identification of the M allele carriers based on phenotype and dog breeds with the merle coat colour accepted by the FCI.

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犬山鸟色被毛的分子背景及其对健康的影响

狗的毛色受许多基因及其多态性的影响。主要的皮毛颜色模式取决于色素类型，即真黑素或褐黑素，其合成受TYRP1基因编码的酪氨酸酶调节。然而，其他基因也有助于最终的表型。其中之一是PMEL负责山鸟色毛色。这篇综述的重点是黑素细胞在毛色表型表达中的作用，山鸟色表型和基因型，M等位基因携带者的表型多样性，负责山鸟色毛色的等位基因携带者的健康后果，以及基于表型识别M等位基因携带者的问题和FCI接受的山鸟色毛色犬种。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Medycyna Weterynaryjna-Veterinary Medicine-Science and Practice VETERINARY SCIENCES-

CiteScore

0.80

自引率

0.00%

发文量

审稿时长

4-8 weeks

期刊介绍： "Medycyna Weterynaryjna" publishes various types of articles which are grouped in the following editorial categories: reviews, original studies, scientific and professional problems, the history of veterinary medicine, posthumous memoirs, as well as chronicles that briefly relate scientific advances and developments in the veterinary profession and medicine. The most important are the first two categories, which are published with short summaries in English. Moreover, from 2001 the editors of "Medycyna Weterynaryjna", bearing in mind market demands, has also started publishing entire works in English. Since 2008 the periodical has appeared in an electronic version. The following are available in this version: summaries of studies published from 1999 to 2005, full versions of all the studies published in the years 2006-2011 (in pdf files), and full versions of the English studies published in the current year (pdf). Only summaries of the remaining studies from the current year are available. In accordance with the principles accepted by the editors, the full versions of these texts will not be made available until next year. All articles are evaluated twice by leading Polish scientists and professionals before they are considered for publication. For years now "Medycyna Weterynaryjna" has maintained a high standard thanks to this system. The review articles are actually succinct monographs dealing with specific scientific and professional problems that are based on the most recent findings. Original works have a particular value, since they present research carried out in Polish and international scientific centers.