Poly(2-methacryloyloxyethyl phosphorylcholine) (MPC) nanofibers coated with micro-patterned diamond-like carbon (DLC) for the controlled drug release

Abstract

Attaining high hemocompatibility and promoting endothelialization are two major keys to solve the endoleak problems observed in existing stent-grafts. For the satisfactory long-term use of the stent-grafts, blocking the endoleak symptom is highly essential. This paper deals with the ­fabrication­of­electrospun­nanofibers­made­of­antithrombogenic poly(2-methacryloyloxyethyl phosphorylcholine) (MPC) containing drug that can sustain the endothelial activity­of­the­MPC­nanofibers.­Moreover,­the­drug­release­ was controlled by micro-patterned diamond-like carbon (DLC) coated on the MPC nanofibers. It was found that MPC­nanofibers­ retained­excellent­hemocompatibility­and­ that the micro-patterned DLC efficiently controlled the drug-release­rate­of­MPC­fibers.