{"title":"Red cell distribution width in cardiac diseases: Role of hemorheology and chronic inflammation","authors":"Panayiotis D. Megaloikonomos, K. Nakashima","doi":"10.17106/jbr.37.13","DOIUrl":"https://doi.org/10.17106/jbr.37.13","url":null,"abstract":"","PeriodicalId":39272,"journal":{"name":"Journal of Biorheology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68199015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Investigation of erythrocyte aggregation parameters of blood with low levels of fibrinogen by syllectometry","authors":"Makoto Higuchi, Masayoshi Tanaka, Nobuo Watanabe","doi":"10.17106/jbr.37.2","DOIUrl":"https://doi.org/10.17106/jbr.37.2","url":null,"abstract":"","PeriodicalId":39272,"journal":{"name":"Journal of Biorheology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68199312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effect of O2 concentration on arteriole diameter near stimulated neurons in the cortex","authors":"Tatsuya Sato, Saori Sasaki, T. Sera, S. Kudo","doi":"10.17106/jbr.37.9","DOIUrl":"https://doi.org/10.17106/jbr.37.9","url":null,"abstract":"","PeriodicalId":39272,"journal":{"name":"Journal of Biorheology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68199459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shigeaki Makino, K. Shimano, Suguru Shiratori, H. Nagano, H. Ujiié
{"title":"Influence of different outflow boundary conditions on hemodynamic analysis of cerebral aneurysm","authors":"Shigeaki Makino, K. Shimano, Suguru Shiratori, H. Nagano, H. Ujiié","doi":"10.17106/jbr.37.21","DOIUrl":"https://doi.org/10.17106/jbr.37.21","url":null,"abstract":"","PeriodicalId":39272,"journal":{"name":"Journal of Biorheology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68199399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Peripheral artery disease (PAD) is an obstructive arterial disease of the lower extremities. Due to the aging society and improved diagnostic techniques, the number of patients identified with PAD is increasing. Endovascular treatment (EVT) is a widely accepted interventional management method for diseased lower extremity arteries. Ana-tomically, the arteries of the lower extremities are divided into three segments: aortoiliac, femoropopliteal, and below-the-knee. The strategies of EVT recommended in the relevant guidelines are different for each segment. During the past 20 years, the indications and strategies of EVT have been evolving owing to the development of devices and improvement of clinical outcomes of EVT. Although it might be challenging to catch up with the evolving EVT strategies, we should develop an optimal EVT strategy for each PAD patient, considering that patient and lesion characteristics would also affect clinical outcomes. In this review, we describe the current knowledge of EVT strategies for each segment. We selected the EVT strategies that are currently performed for a majority of symptomatic PAD patients.
{"title":"Strategies of endovascular intervention for patients with symptomatic lower extremity artery disease","authors":"E. Karashima, M. Fujihara","doi":"10.17106/jbr.36.3","DOIUrl":"https://doi.org/10.17106/jbr.36.3","url":null,"abstract":"Peripheral artery disease (PAD) is an obstructive arterial disease of the lower extremities. Due to the aging society and improved diagnostic techniques, the number of patients identified with PAD is increasing. Endovascular treatment (EVT) is a widely accepted interventional management method for diseased lower extremity arteries. Ana-tomically, the arteries of the lower extremities are divided into three segments: aortoiliac, femoropopliteal, and below-the-knee. The strategies of EVT recommended in the relevant guidelines are different for each segment. During the past 20 years, the indications and strategies of EVT have been evolving owing to the development of devices and improvement of clinical outcomes of EVT. Although it might be challenging to catch up with the evolving EVT strategies, we should develop an optimal EVT strategy for each PAD patient, considering that patient and lesion characteristics would also affect clinical outcomes. In this review, we describe the current knowledge of EVT strategies for each segment. We selected the EVT strategies that are currently performed for a majority of symptomatic PAD patients.","PeriodicalId":39272,"journal":{"name":"Journal of Biorheology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68199193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kazumasa Fujita, S. Kajiyama, Hiroo Noguchi, T. Arita
Atrial fibrillation (AF) is one of the most preva lent arrythmias worldwide and associated with an increased risk of stroke and systemic thromboembolism. Stroke pre vention with direct oral anticoagulation (DOAC) is recom mended in patients with non-valvular AF (NVAF) at high risk of stroke. WATCHMAN TM percutaneous left atrial appendage closure (LAAC) device is currently introduced as an alternative to DOAC for patients with NVAF ineligi ble for long-term administration of DOAC due to high risk of bleeding. This review article may contribute to recognize the paradigm shift in which stroke prevention should be carried out topically but not systemically, because left atrial appendage (LAA) is the main source of thrombus formation in AF patients. In addition, this review article introduces the current knowledge and future perspective of LAAC strategy and technology.
{"title":"Percutaneous left atrial appendage closure for stroke prevention in patients with atrial fibrillation: Current status and future perspective","authors":"Kazumasa Fujita, S. Kajiyama, Hiroo Noguchi, T. Arita","doi":"10.17106/jbr.36.31","DOIUrl":"https://doi.org/10.17106/jbr.36.31","url":null,"abstract":"Atrial fibrillation (AF) is one of the most preva lent arrythmias worldwide and associated with an increased risk of stroke and systemic thromboembolism. Stroke pre vention with direct oral anticoagulation (DOAC) is recom mended in patients with non-valvular AF (NVAF) at high risk of stroke. WATCHMAN TM percutaneous left atrial appendage closure (LAAC) device is currently introduced as an alternative to DOAC for patients with NVAF ineligi ble for long-term administration of DOAC due to high risk of bleeding. This review article may contribute to recognize the paradigm shift in which stroke prevention should be carried out topically but not systemically, because left atrial appendage (LAA) is the main source of thrombus formation in AF patients. In addition, this review article introduces the current knowledge and future perspective of LAAC strategy and technology.","PeriodicalId":39272,"journal":{"name":"Journal of Biorheology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68198813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Left ventricular assist device (LVAD) is an important therapeutic option for patients with end-stage advanced heart failure. LVAD can reduce cardiovascular death and improve the quality of life in patients with end-stage advanced heart failure. However, as LVAD-implanted patients increase and survival becomes prolonged, many patients experience serious complications. Major complications of LVAD include ischemic and hemorrhagic strokes, bleeding complications, device thrombosis, right heart failure, and LVAD related infections. These complications lead to worse mortality in patients with LVAD. In particular, cerebrovascular events and gastrointestinal bleeding are the most dreaded complications. High molecule weight multimers of von Willebrand factor (vWF-HMWM) play an essential role in platelet adhesion and aggregation, but high shear stress caused by LVAD pump diminishes the vWF-HMWM. In fact, in response to the shear stress of LVAD, vWF exposes cleavage domains of ADAMTS 13 to form smaller multimeric molecules. Therefore, in many patients with LVAD, the vWF reduces its large multimers and lowers the ability to bind sufficiently to platelets and sub-endothelial collagen, resulting in the acquired von Willebrand syndrome. Thus, in LVAD patients with acquired von Willebrand syndrome, vWF function is impaired, and this impairment is associated with hemocompatibility-related adverse events. Based on hemorheology, this review focuses on the pathophysiology of acquired von Willebrand syndrome and its management in patients with LVAD.
{"title":"Acquired von Willebrand syndrome and hemocompatibility-related adverse events in patients with left ventricular assist device","authors":"M. Hieda, Panayiotis D. Megaloikonomos","doi":"10.17106/jbr.36.12","DOIUrl":"https://doi.org/10.17106/jbr.36.12","url":null,"abstract":"Left ventricular assist device (LVAD) is an important therapeutic option for patients with end-stage advanced heart failure. LVAD can reduce cardiovascular death and improve the quality of life in patients with end-stage advanced heart failure. However, as LVAD-implanted patients increase and survival becomes prolonged, many patients experience serious complications. Major complications of LVAD include ischemic and hemorrhagic strokes, bleeding complications, device thrombosis, right heart failure, and LVAD related infections. These complications lead to worse mortality in patients with LVAD. In particular, cerebrovascular events and gastrointestinal bleeding are the most dreaded complications. High molecule weight multimers of von Willebrand factor (vWF-HMWM) play an essential role in platelet adhesion and aggregation, but high shear stress caused by LVAD pump diminishes the vWF-HMWM. In fact, in response to the shear stress of LVAD, vWF exposes cleavage domains of ADAMTS 13 to form smaller multimeric molecules. Therefore, in many patients with LVAD, the vWF reduces its large multimers and lowers the ability to bind sufficiently to platelets and sub-endothelial collagen, resulting in the acquired von Willebrand syndrome. Thus, in LVAD patients with acquired von Willebrand syndrome, vWF function is impaired, and this impairment is associated with hemocompatibility-related adverse events. Based on hemorheology, this review focuses on the pathophysiology of acquired von Willebrand syndrome and its management in patients with LVAD.","PeriodicalId":39272,"journal":{"name":"Journal of Biorheology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68198557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Kawano, Takako (Osawa) Yagi, M. Hoshino, Takeshi Matsumoto
Quantification of deformation behavior of artic ular cartilage (AC) is crucial for understanding its mechani cal function and response to mechanical stimuli. Here, we explored whether grating-based phase-contrast X-ray CT using monochromatic synchrotron light (grating-based msPXCT) enables in-situ quantification of local deforma tion in AC. Grating-based msPXCT of a porcine AC sample during axial compression test was conducted using a Talbot grating interferometer. Local displacements and strains were computed using a digital volume correlation method. The magnitude of axial strain decreased from the upper to middle sample zones and reached almost constant over the middle-lower zone, consistent with the depth-dependent density increase with compression. Thus, grating-based msPXCT may be suitable for quantitative analysis of AC deformation.
{"title":"In-situ deformation imaging of articular cartilage using grating-based phase-contrast X-ray CT at a synchrotron light source","authors":"S. Kawano, Takako (Osawa) Yagi, M. Hoshino, Takeshi Matsumoto","doi":"10.17106/jbr.36.51","DOIUrl":"https://doi.org/10.17106/jbr.36.51","url":null,"abstract":"Quantification of deformation behavior of artic ular cartilage (AC) is crucial for understanding its mechani cal function and response to mechanical stimuli. Here, we explored whether grating-based phase-contrast X-ray CT using monochromatic synchrotron light (grating-based msPXCT) enables in-situ quantification of local deforma tion in AC. Grating-based msPXCT of a porcine AC sample during axial compression test was conducted using a Talbot grating interferometer. Local displacements and strains were computed using a digital volume correlation method. The magnitude of axial strain decreased from the upper to middle sample zones and reached almost constant over the middle-lower zone, consistent with the depth-dependent density increase with compression. Thus, grating-based msPXCT may be suitable for quantitative analysis of AC deformation.","PeriodicalId":39272,"journal":{"name":"Journal of Biorheology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68199164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Percutaneous coronary intervention (PCI) using balloon technology and stent implantation has revolutionized the interventional cardiology since the late 1970s. The plane old balloon angioplasty (POBA) was first proposed in the late 1970s as an alternative to coronary artery bypass grafting (CABG) for the treatment of coronary artery disease (CAD) such as angina pectoris and acute myocardial infarction (AMI). Thereafter, bare metal stent (BMS) was designed to overcome the problems proposed by POBA such as acute occlusion and restenosis of coronary target lesion. However, a new problem of BMS-induced in-stent restenosis (ISR) has appeared, and drug-eluting stent (DES) was introduced to resolve the problem of ISR. DES has improved the clinical outcome of patients undergoing PCI. Contemporary stent technology shows remarkable progress, and further effort continues to improve the design, structure, and materials of DES. However, DES has proposed a new problem of very late stent thrombosis. To overcome this late complication, non-stent strategy is introduced into the PCI. This article aims to review the historical development and future perspective of the PCI especially focusing on the evolution of DES.
自20世纪70年代末以来，使用球囊技术和支架植入的经皮冠状动脉介入治疗(PCI)彻底改变了介入心脏病学。平面旧球囊血管成形术(POBA)于20世纪70年代末首次提出，作为冠状动脉旁路移植术(CABG)的替代方案，用于治疗冠心病(CAD)，如心绞痛和急性心肌梗死(AMI)。因此，裸金属支架(bare metal stent, BMS)的设计克服了POBA带来的冠状动脉靶病变急性闭塞、再狭窄等问题。然而，bms诱导支架内再狭窄(ISR)的新问题已经出现，药物洗脱支架(DES)的引入解决了ISR问题。DES改善了PCI患者的临床预后。当代支架技术取得了显著的进步，DES的设计、结构和材料不断得到改进，但DES也提出了一个新的问题，即非常晚期的支架血栓形成。为了克服这种晚期并发症，PCI引入了非支架策略。本文旨在回顾PCI的历史发展和未来前景，特别是关注DES的发展。
{"title":"Historical overview and future perspective of the percutaneous coronary intervention with special emphasis on the development of coronary stent","authors":"G. Nakaji, Maroka Shinchi, Y. Ohba, A. Koike","doi":"10.17106/jbr.36.23","DOIUrl":"https://doi.org/10.17106/jbr.36.23","url":null,"abstract":"Percutaneous coronary intervention (PCI) using balloon technology and stent implantation has revolutionized the interventional cardiology since the late 1970s. The plane old balloon angioplasty (POBA) was first proposed in the late 1970s as an alternative to coronary artery bypass grafting (CABG) for the treatment of coronary artery disease (CAD) such as angina pectoris and acute myocardial infarction (AMI). Thereafter, bare metal stent (BMS) was designed to overcome the problems proposed by POBA such as acute occlusion and restenosis of coronary target lesion. However, a new problem of BMS-induced in-stent restenosis (ISR) has appeared, and drug-eluting stent (DES) was introduced to resolve the problem of ISR. DES has improved the clinical outcome of patients undergoing PCI. Contemporary stent technology shows remarkable progress, and further effort continues to improve the design, structure, and materials of DES. However, DES has proposed a new problem of very late stent thrombosis. To overcome this late complication, non-stent strategy is introduced into the PCI. This article aims to review the historical development and future perspective of the PCI especially focusing on the evolution of DES.","PeriodicalId":39272,"journal":{"name":"Journal of Biorheology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68198337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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