C. Manojmouli, T. Pasha, K. Nagaprashant, B. Ramesh, Eain Ul, K. Purushotham
{"title":"Flavonoid derivatives as anticancer moiety and its effect on cancer cell lines: An updated review","authors":"C. Manojmouli, T. Pasha, K. Nagaprashant, B. Ramesh, Eain Ul, K. Purushotham","doi":"10.2298/jsc221228041m","DOIUrl":null,"url":null,"abstract":"Cancer is now considered the number one leading cause of premature death in industrialized countries. Chemotherapy drugs are quite expensive and cause multiple side effects. Natural products have been studied in depth for their potential as anticancer agents because of their remarkable chemical variability. Among the various natural metabolites, flavonoids are secondary metabolites that are extensively present in nature, have potent anti-cancer properties, have few adverse effects, and also show synergistic benefits. Numerous laboratories are diligently investigating the chemistry and biology of novel flavonoid derivatives due to the demand for and worth of these drugs. In this review, we summarized clinical trials of various flavonoids, molecular pathways against various cancer cell lines, and recent updates on the anticancer activity of flavonoid derivatives against various cancer cells synthesized by various methods, more studies are needed to develop the following mentioned flavonoid derivatives as an anticancer drug.","PeriodicalId":17489,"journal":{"name":"Journal of The Serbian Chemical Society","volume":"1 1","pages":""},"PeriodicalIF":1.0000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of The Serbian Chemical Society","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.2298/jsc221228041m","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Cancer is now considered the number one leading cause of premature death in industrialized countries. Chemotherapy drugs are quite expensive and cause multiple side effects. Natural products have been studied in depth for their potential as anticancer agents because of their remarkable chemical variability. Among the various natural metabolites, flavonoids are secondary metabolites that are extensively present in nature, have potent anti-cancer properties, have few adverse effects, and also show synergistic benefits. Numerous laboratories are diligently investigating the chemistry and biology of novel flavonoid derivatives due to the demand for and worth of these drugs. In this review, we summarized clinical trials of various flavonoids, molecular pathways against various cancer cell lines, and recent updates on the anticancer activity of flavonoid derivatives against various cancer cells synthesized by various methods, more studies are needed to develop the following mentioned flavonoid derivatives as an anticancer drug.
期刊介绍：
The Journal of the Serbian Chemical Society -JSCS (formerly Glasnik Hemijskog društva Beograd) publishes articles original papers that have not been published previously, from the fields of fundamental and applied chemistry:
Theoretical Chemistry, Organic Chemistry, Biochemistry and Biotechnology, Food Chemistry, Technology and Engineering, Inorganic Chemistry, Polymers, Analytical Chemistry, Physical Chemistry, Spectroscopy, Electrochemistry, Thermodynamics, Chemical Engineering, Textile Engineering, Materials, Ceramics, Metallurgy, Geochemistry, Environmental Chemistry, History of and Education in Chemistry.
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