Microbiome and Neurotrauma: Emerging Innovations.

A. Clark, R. Zelmanovich, M. R. Hosseini Siyanaki, M. Michel, C. Hanna, C. Davidson, B. Lucke-Wold
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Abstract

The gut-brain axis plays an important role in bidirectional communication that exists and can be altered by injury. Neurotrauma provides acute alteration in the GI tract and alters autonomic function. In this focused review, we highlight what is known about GI disruption following neurotrauma. We then delve into how this affects recovery. Areas of innovation and emerging pre-clinical results are addressed. Finally, we address the link between neurotrauma induced GI dysfunction and progression to neurodegenerative disease states.
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微生物组和神经创伤:新兴的创新。
肠脑轴在双向交流中起着重要作用,这种双向交流存在并可能因损伤而改变。神经创伤可引起胃肠道的急性改变并改变自主神经功能。在这篇重点综述中,我们强调了神经外伤后胃肠道紊乱的已知情况。然后我们深入研究这是如何影响恢复的。讨论了创新领域和新出现的临床前结果。最后,我们讨论了神经创伤诱导的胃肠道功能障碍与神经退行性疾病状态进展之间的联系。
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Microbiome and Neurotrauma: Emerging Innovations. Microbiome and Neurotrauma: Emerging Innovations. Retrograde Synaptic Transmitter of Endocannabinoid System - A Neuromodulatory Pathway A Focus on an Atypical Acute Disseminated Encephalomyelitis Moonstroke & MUSS
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