Phytotherapy compared to omeprazol therapy in equine gastric ulcers

IF 0.6 4区农林科学 Q3 VETERINARY SCIENCES Acta Veterinaria Brno Pub Date : 2022-01-01 DOI:10.2754/avb202291040309

Margaréta Kulcsár, Michaela Karamanová, F. Novotny, Z. Vilhanová, M. Pettenello, C. Tóthová

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Abstract

The aim of this study was to offer an alternative therapy for gastric ulcers in horses as the interest in natural products is growing not only among practicioners but also horse owners. We compared the treatment of equine gastric squamous mucosa ulcers by omeprazol and by nutraceutical herbal mixture PREVUL (Dzsar Ltd., FitoCavallo, Hungary). A total of 36 horses, 18 geldings, 15 non-pregnant mares and 3 stallions were diagnosed with Equine Squamous Gastric Disease (ESGD) by gastroscopy. Horses were randomly divided into three groups. The first group was treated with 4 mg/kg omeprazole paste (Peptizole, Norbrook, United Kingdom) per os once daily on empty stomach for 28 days. The second group received 20 g of pulverized herbal mixture PREVUL twice daily in cracked oats for 28 days. The third experimental group received 2 mg/kg omeprazole per os once daily on empty stomach followed by 15 g of PREVUL mixed with cracked oats twice daily for 28 days. Ten healthy horses were used as control to evaluate the palatability and voluntary intake of PREVUL. Control gastroscopy was performed afted 30 days. The use of PREVUL alone P < 0.05 or in combination with omeprazole paste P < 0.01 appears to improve the healing of gastric ulcers in horses.

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植物疗法与奥美拉唑治疗马胃溃疡的比较

这项研究的目的是为马胃溃疡提供一种替代疗法，因为不仅在医生中，而且在马主人中，对天然产品的兴趣正在增长。我们比较了奥美拉唑和营养保健品混合草药PREVUL (Dzsar Ltd.， FitoCavallo, Hungary)治疗马胃粘膜溃疡的疗效。共36匹马，18匹阉马，15匹未怀孕母马和3匹种马经胃镜检查诊断为马鳞胃病(ESGD)。马被随机分成三组。第一组患者给予奥美拉唑糊剂(Peptizole, Norbrook，英国)4 mg/kg，每日1次，空腹治疗，连续28 d。第二组服用20克草药混合粉末PREVUL，每天两次，连续28天。第三个实验组给予奥美拉唑2 mg/kg / s，每天1次，空腹，随后给予PREVUL与燕麦混合15 g，每天2次，连用28天。以10匹健康马为对照，评价PREVUL的适口性和自愿摄入量。对照组于30天后进行胃镜检查。单独使用PREVUL P < 0.05或与奥美拉唑糊剂联合使用P < 0.01均能促进马胃溃疡的愈合。

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来源期刊

Acta Veterinaria Brno 农林科学-兽医学

CiteScore

1.00

自引率

33.30%

发文量

审稿时长

18-36 weeks

期刊介绍： ACTA VETERINARIA BRNO is a scientific journal of the University of Veterinary and Pharmaceutical Sciences in Brno, Czech Republic. The scientific journal Acta Veterinaria Brno is dedicated to the publication of original research findings and clinical observations in veterinary and biomedical sciences. Original scientific research articles reporting new and substantial contribution to veterinary science and original methods that have not been submitted for publication elsewhere are considered for publication. A written statement to this effect should accompany the manuscript, along with approval for publication by the author´s head of department. The authors bear full responsibility for the contents of their contribution. Book reviews are published, too.