Evaluation of mammary gland health in dairy cows treated by pegylated granulocyte colony-stimulating factor

IF 0.6 4区农林科学 Q3 VETERINARY SCIENCES Acta Veterinaria Brno Pub Date : 2023-01-01 DOI:10.2754/avb202392010003

Josef Tabery, M. Andrlíková, V. Bína, Adriena Hochmanová, E. Indrová, Monika Mizeráková, T. Páleník, Veronika Stařecká, Kateřina Švédová, S. Čech

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Abstract

The study aimed to determine the effect of the treatment by pegbovigrastim on the health of the mammary gland in dairy cows. Experimental animals were successively treated with 15 mg of pegylated bovine granulocyte colony-stimulating factor (bG-CSF, pegbovigrastim, PEG, Imrestor, Elanco) 10 ± 3 days before expected parturition and 1 day after actual parturition. Cows in the control group remained without treatment. The occurrence of clinical and subclinical mastitis in dairy cows during the first three months postpartum, and bacteriological findings in milk and milk yield were evaluated after preventive pegbovigrastim treatment. The influence of pegbovigrastim, as an additional treatment of mastitis caused by Streptococcus uberis in dairy cows on the standard course of treatment, was evaluated. The average number of antimicrobial (AML) interventions necessary for healing, the proportion of cows with 1, 2, 3 and more AML interventions, milk somatic cell count before treatment, 1 and 2 months after treatment and average milk withdrawal time were evaluated between groups. The results of the study did not find positive effects of pegbovigrastim on any evaluated variables.

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聚乙二醇化粒细胞集落刺激因子对奶牛乳腺健康的影响

本研究旨在确定聚乙二醇维拉西汀对奶牛乳腺健康的影响。实验动物分别于预产前10±3天和实际分娩后1天分别给予聚乙二醇化牛粒细胞集落刺激因子(bG-CSF、pegbovigrastim、PEG、Imrestor、Elanco) 15 mg。对照组奶牛不进行任何处理。对奶牛产后3个月内临床和亚临床乳腺炎的发生情况、乳汁细菌学检查结果和产奶量进行了评估。pegbovigrastim作为奶牛由uberis链球菌引起的乳腺炎的一种额外治疗，对标准治疗过程的影响进行了评估。评估各组愈合所需的平均抗菌药物(AML)干预次数、接受1、2、3及以上抗菌药物干预的奶牛比例、治疗前、治疗后1、2个月乳体细胞计数和平均停乳时间。研究结果没有发现pegbovigrastim对任何评估变量的积极影响。

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来源期刊

Acta Veterinaria Brno 农林科学-兽医学

CiteScore

1.00

自引率

33.30%

发文量

审稿时长

18-36 weeks

期刊介绍： ACTA VETERINARIA BRNO is a scientific journal of the University of Veterinary and Pharmaceutical Sciences in Brno, Czech Republic. The scientific journal Acta Veterinaria Brno is dedicated to the publication of original research findings and clinical observations in veterinary and biomedical sciences. Original scientific research articles reporting new and substantial contribution to veterinary science and original methods that have not been submitted for publication elsewhere are considered for publication. A written statement to this effect should accompany the manuscript, along with approval for publication by the author´s head of department. The authors bear full responsibility for the contents of their contribution. Book reviews are published, too.