Rose and eucalyptus essential oil as potent anti-liver cancer agents

IF 1.6 Q2 AGRICULTURE, MULTIDISCIPLINARY Asian Journal of Agriculture and Biology Pub Date : 2023-01-01 DOI:10.35495/ajab.2022.141

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Abstract

The present study was designed to investigate the anti-cancer potential of essential oil obtained from Rosa indica (REO) and Eucalyptus citriodora (EEO) against the liver carcinoma cell line (HepG2). Firstly, the cytotoxic activity was assessed using increasing concentrations ranging from 3.12 to 200 µg/ml via MTT assay. EEO showed only 2% cell viability while REO represented 18% at the highest concentration (200 μg/ml). The half-maximal inhibitory concentration (IC 50 ) of EEO and REO was found to be 17.741 µg/ml and 18.55 µg/ml respectively. Additionally, evident morphological changes in HepG2 cells were observed after 24 hours of essential oil treatment compared to control or untreated cells. Furthermore, to strengthen the anti-cancer perspective of essential oils, the anti-metastatic potential was evaluated through the wound healing assay. EEO promisingly inhibited migration (4% wound closure, **p > 0.01) in HepG2 cells after 24 hr treatment. Likewise, REO also exhibited good results (37% wound closure, ***p > 0.001). Conclusively, the present investigation provides preliminary results which suggest that REO and EEO are potent anti-cancer agents against hepatocellular carcinoma.

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来源期刊

Asian Journal of Agriculture and Biology AGRICULTURE, MULTIDISCIPLINARY-

CiteScore

2.80

自引率

4.50%

发文量

审稿时长

6 weeks

期刊介绍： Asian Journal of Agriculture and Biology (AJAB) is a peer reviewed, open access, quarterly journal serving as a means for scientific information exchange in international and national fora. The scope encompasses all disciplines of agriculture and biology including animal, plant and environmental sciences. All manuscripts are evaluated for their scientific content and significance by the Editor-in-Chief &/or Managing Editor and at least two independent reviewers. All submitted manuscripts should contain unpublished original research which should not be under consideration for publication elsewhere. In order to avoid unnecessary delay in publication, authors are requested to comply the following guidelines; differing these, your submission will be returned for additional revision.