{"title":"Research progress on role of pyroptosis in pathogenesis of myelodyplastic syndrome","authors":"C. Ling, Qi-Chuan Jin, W. Gong, Qi-guo Zhang","doi":"10.3760/CMA.J.ISSN.1673-419X.2018.06.014","DOIUrl":null,"url":null,"abstract":"Pyroptosis is the programmed cell death mediated by inflammatory cysteine-aspartic protease (Caspase). Intercallular or extracellular pathogens can promote the formation of inflammatory by activating Caspase-1, Caspase-4/5/11, pro-interleukin (IL)-1β and pro-IL-18. The activated inflammatory cytokines lead to cell lysis and inflammatory factors release, and finally induced cell death.The alterations of Toll like receptor(TLR) signaling pathway and bone microenvironment, and presence of inflammasome could cause the formation of an inflammatory environment, leading to myelodyplastic syndrome (MDS). The article reviews the mechanism of pyroptosis and the relationship between pyroptosis and MDS. \n \n \nKey words: \nPyroptosis; Myelodyplastic syndrome; Caspases; Interleukin-1beta; Interleukin-18","PeriodicalId":13774,"journal":{"name":"国际输血及血液学杂志","volume":"41 1","pages":"535-538"},"PeriodicalIF":0.0000,"publicationDate":"2018-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"国际输血及血液学杂志","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3760/CMA.J.ISSN.1673-419X.2018.06.014","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Pyroptosis is the programmed cell death mediated by inflammatory cysteine-aspartic protease (Caspase). Intercallular or extracellular pathogens can promote the formation of inflammatory by activating Caspase-1, Caspase-4/5/11, pro-interleukin (IL)-1β and pro-IL-18. The activated inflammatory cytokines lead to cell lysis and inflammatory factors release, and finally induced cell death.The alterations of Toll like receptor(TLR) signaling pathway and bone microenvironment, and presence of inflammasome could cause the formation of an inflammatory environment, leading to myelodyplastic syndrome (MDS). The article reviews the mechanism of pyroptosis and the relationship between pyroptosis and MDS.
Key words:
Pyroptosis; Myelodyplastic syndrome; Caspases; Interleukin-1beta; Interleukin-18
期刊介绍：
The International Journal of Transfusion and Hematology was founded in September 1978. It is a comprehensive academic journal in the field of transfusion and hematology, supervised by the National Health Commission and co-sponsored by the Chinese Medical Association, West China Second Hospital of Sichuan University, and the Institute of Transfusion Medicine of the Chinese Academy of Medical Sciences. The journal is a comprehensive academic journal that combines the basic and clinical aspects of transfusion and hematology and is publicly distributed at home and abroad. The International Journal of Transfusion and Hematology mainly reports on the basic and clinical scientific research results and progress in the field of transfusion and hematology, new experiences, new methods, and new technologies in clinical diagnosis and treatment, introduces domestic and foreign research trends, conducts academic exchanges, and promotes the development of basic and clinical research in the field of transfusion and hematology.
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