{"title":"Comprehensive Synthesis of 20 Fentanyl Derivatives for Their Rapid Differentiation by GC-MS Analysis","authors":"Takashi Misawa, Genichiro Tsuji, Takashi Kurohara, T. Ito, Hidetomo Yokoo, Maiko Kawamura, Takuji Shoda, Ruri Hanajiri-kikura, Yosuke Demizu","doi":"10.3987/com-22-14760","DOIUrl":null,"url":null,"abstract":"– Fentanyl, a selective agonist of opioid μ receptors, is a broadly used clinical agent for anesthesia and pain relief. Despite its clinical benefits, the abuse of fentanyl and its derivatives causes a number of health concerns, which are increasing at an alarming rate; its abuse has become a serious social problem. These compounds are often difficult to obtain as reagents","PeriodicalId":13166,"journal":{"name":"Heterocycles","volume":null,"pages":null},"PeriodicalIF":0.8000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Heterocycles","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.3987/com-22-14760","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
引用次数: 0
Abstract
– Fentanyl, a selective agonist of opioid μ receptors, is a broadly used clinical agent for anesthesia and pain relief. Despite its clinical benefits, the abuse of fentanyl and its derivatives causes a number of health concerns, which are increasing at an alarming rate; its abuse has become a serious social problem. These compounds are often difficult to obtain as reagents
期刊介绍：
Since its inception in 1973 HETEROCYCLES has provided a platform for the rapid exchange of research in the areas of organic, pharmaceutical, analytical, and medicinal chemistry of heterocyclic compounds in addition to communications, papers, reviews, a special section of the journal presents newly-discovered natural products whose structure has recently been established.
Another section is devoted to the total synthesis of previously documented natural products with heterocyclic ring systems.
Due to the fact that the journal is able to publish articles within two months of receipt of the manuscripts, researchers in this field can obtain up-to-date information on heterocyclic research by reading Heterocycles regularly.
Audience: Organic and Physical Organic Chemists, Biochemists, Pharmacologists and Scientists studying heterocyclic compounds
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