The Effects of tDCS on Depression and Anxiety Disorders Induced by Sub-Chronic Stress

Q4 Medicine Turk hijiyen ve deneysel biyoloji dergisi. Turkish bulletin of hygiene and experimental biology Pub Date : 2022-01-01 DOI:10.5505/turkhijyen.2022.06641

G. Akcay, N. Derin

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引用次数: 2

Abstract

Objective: Stress causes neuropsychiatric diseases such as depression and anxiety in the person by affecting emotions, opinions and behaviors. In this study, the aim was to investigate the therapeutic effects of tDCS on depression and anxiety disorders that occur after sub-chronic stress. Methods: 40 male Wistar rats weighing 290-310 g were divided into four groups as control, tDCS, stress and stress+tDCS. Restraint stress was applied for 7 days (2 h/day) as a stress model. Rats in the tDCS and stress+tDCS groups were performed the stimulation of 1 mA anodal tDCS for three consecutive days from the 5th day of stress exposure. On the 7th day of the experiment, the anxiety and depression behaviors of the rats were evaluated ANKSIYETE BOZUKLUKLARI indicator of anxiety (p<0.001). In the stress + tDCS group compared to the control group, there was a significant decrease in the data indicator of anxiety following tDCS application (p <0.05), but no significant difference was found in the results of locomotor activity. Conclusion: In conclusion, our data showed that tDCS stimulation may have an effect on sub-chronic stress-induced anxiety and

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tDCS对亚慢性应激所致抑郁和焦虑障碍的影响

目的:应激通过影响人的情绪、观点和行为而引起抑郁、焦虑等神经精神疾病。本研究旨在探讨tDCS对亚慢性应激后出现的抑郁和焦虑障碍的治疗效果。方法:体重290 ~ 310 g雄性Wistar大鼠40只，随机分为对照组、tDCS组、应激组和应激+tDCS组。施加约束应力7 d (2 h/d)作为应力模型。tDCS组和应激+tDCS组大鼠从应激暴露第5天起连续3天进行1 mA的tDCS阳极刺激。实验第7天对大鼠的焦虑和抑郁行为进行ANKSIYETE BOZUKLUKLARI焦虑指标评价(p<0.001)。应激+ tDCS组与对照组相比，使用tDCS后焦虑数据指标显著降低(p <0.05)，但运动活动结果无显著差异。结论:我们的数据表明，tDCS刺激可能对亚慢性应激性焦虑和应激性焦虑有影响

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Turk hijiyen ve deneysel biyoloji dergisi. Turkish bulletin of hygiene and experimental biology Medicine-Infectious Diseases

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