To study the expression of estrogen, progesterone receptor and p53 immunohistochemistry markers in subtyping endometrial carcinoma.

IF 0.8 4区医学 Q4 PATHOLOGY Indian Journal of Pathology and Microbiology Pub Date : 2024-01-01 DOI:10.4103/ijpm.ijpm_568_22

Anuja Yadav, Anuradha Sistla, Meenakshi Swain, Swarnalata Gowrishankar, Michelle de Padua, Tejal Modi, Rallabandi Himabindu, Neha Agarwal, Aditya Kulkarni, Trilok Bhandari, Hemanth Vudayaraju, Chinnababu, Vijay A Reddy

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Abstract

Background: Endometrial cancer is one of the most commonly diagnosed cancers in women worldwide.

Aim and objectives: To study the expression of estrogen receptor (ER), progesterone receptor (PR) and p53 immunohistochemistry (IHC) markers in subtyping endometrial carcinoma. Materials and Methods: A total of 100 cases of carcinoma endometrium submitted during January 2016 to October 2018 were included in our study. The ER, PR and p53 expressions were scored as per the adopted scoring system. Agreement between ER, PR and p53 IHC expression and the consensus HE diagnosis, FIGO grading and tumour staging were assessed using Chi square tests.

Results: There was a statistical association between ER, PR and p53 status and tumour histologic type with a P value < 0.01. There was no statistical significance observed between ER and PR expressions and different FIGO grades. Statistical significance (P = 0.036) between p53 and different FIGO grades seen. No statistical significance was observed between ER, PR and p53 expressions and different tumour stages and tumour invasiveness. There was a statistical association between ER and PR status and lymph node metastasis. p53 did not show a statistical significance.

Conclusion: Combination of ER, PR and p53 IHC markers can be used to distinguish type 1 and type 2 endometrial cancers. PR expression is more specific than ER in endometrioid carcinomas. p53 expression is more specific in serous carcinoma, however, p53 IHC alone cannot be used to distinguish different grades of endometrioid carcinomas as there is variability of staining in endometrioid carcinomas.

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研究雌激素、孕激素受体和 p53 免疫组化标记物在子宫内膜癌亚型中的表达。

背景：子宫内膜癌是全球妇女最常见的癌症之一：目的和目标：研究雌激素受体（ER）、孕激素受体（PR）和 p53 免疫组织化学（IHC）标记物在子宫内膜癌亚型中的表达：研究雌激素受体（ER）、孕激素受体（PR）和p53免疫组化（IHC）标记物在子宫内膜癌亚型中的表达。材料与方法：本研究共纳入2016年1月至2018年10月期间提交的100例子宫内膜癌病例。按照采用的评分系统对ER、PR和p53的表达进行评分。ER、PR和p53 IHC表达与HE共识诊断、FIGO分级和肿瘤分期之间的一致性采用Chi square检验进行评估：结果：ER、PR 和 p53 状态与肿瘤组织学类型之间存在统计学关联，P 值小于 0.01。ER和PR的表达与不同的FIGO分级之间没有统计学意义。p53 与不同 FIGO 分级之间存在统计学意义（P = 0.036）。ER、PR 和 p53 表达与不同肿瘤分期和肿瘤侵袭性之间无统计学意义。ER和PR状态与淋巴结转移之间存在统计学关联，而p53则没有统计学意义：结论：结合ER、PR和p53 IHC标记可用于区分1型和2型子宫内膜癌。在浆液性癌中，p53 的表达更具特异性，但由于子宫内膜样癌的染色存在变异性，因此不能单独使用 p53 IHC 来区分不同等级的子宫内膜样癌。

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来源期刊

Indian Journal of Pathology and Microbiology PATHOLOGY-

CiteScore

1.20

自引率

0.00%

发文量

422

审稿时长

1 months

期刊介绍： The journal will cover studies related to pathology including morbid anatomy, surgical pathology, clinical pathology, diagnostic cytopathology including gynecologic cytology and aspiration cytology, hematology including immuno-hematology and medical microbiology. The journal gives preference to clinically oriented studies over experimental and animal studies. The Journal would publish peer-reviewed original research papers, case reports, systematic reviews, meta-analysis, letters to the editor and brief communications. Review articles on current topics usually are invited by the editor.