The clinical significance of SNAIL, TWIST, and E-Cadherin expression in gastric mesentery tumor deposits of advanced gastric cancer.

IF 0.5 4区医学 Q4 PATHOLOGY Indian Journal of Pathology and Microbiology Pub Date : 2024-01-01 DOI:10.4103/ijpm.ijpm_659_22

Haiyan Wu, Yanping Chen, Huimei Lin, Yanchang Xu, Zipei Guo, Zhixiong Li

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Abstract

Objective: To explore the relationships among the epithelial to mesenchymal transition (EMT)-related factors (SNAIL, TWIST, and E-Cadherin) and clinicopathological parameters and gastric mesangial tumor deposits (TDs) in advanced gastric cancer (AGC) patients and their value in gastric cancer prognosis judgment.

Materials and methods: The data of 190 patients who underwent radical resection of ACG were analyzed retrospectively, including 75 cases of TDs (+) and 115 cases of TDs (-). The expression of EMT-related transforming factors Snail, Twist, and E-cadherin in the primary tumor, paracancerous normal tissues, and TDs was detected by immunohistochemistry.

Results: SNAIL and TWIST were overexpressed in primary tumors and TDs, whereas E-Cadherin was down-expressed in primary tumors. SNAIL was correlated significantly with tumor differentiation, lymph node metastases, and TDs (P < 0.05); TWIST was correlated strongly with tumor location, lymph node metastases, and TDs (P < 0.05); E-Cadherin was correlated closely with tumor differentiation and lymph node metastases (P < 0.05). Kaplan-Meier curves showed that SNAIL expression was correlated with DFS (P < 0.05), and TWIST expression was correlated with OS (P < 0.05). Tumor differentiation, lymph node metastasis, and TWIST expression were prognostic-independent risk factors of AGC patients (P < 0.05).

Conclusion: The occurrence and development of gastric cancer and the formation of TDs may be related to EMT, analyzing the expression of EMT-related transforming proteins may be helpful to judge the prognosis of gastric cancer.

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晚期胃癌胃系膜肿瘤沉积物中 SNAIL、TWIST 和 E-Cadherin 表达的临床意义

目的探讨晚期胃癌（AGC）患者上皮细胞向间充质转化（EMT）相关因子（SNAIL、TWIST和E-Cadherin）与临床病理参数及胃间质瘤沉积（TDs）之间的关系及其在胃癌预后判断中的价值：回顾性分析了190例接受根治性切除术的ACG患者的数据，包括75例TDs（+）和115例TDs（-）。免疫组化法检测了原发肿瘤、癌旁正常组织和TDs中与EMT相关的转化因子蜗牛蛋白、Twist和E-cadherin的表达：结果：SNAIL 和 TWIST 在原发性肿瘤和 TDs 中过表达，而 E-Cadherin 在原发性肿瘤中低表达。SNAIL与肿瘤分化、淋巴结转移和TD显著相关（P < 0.05）；TWIST与肿瘤位置、淋巴结转移和TD密切相关（P < 0.05）；E-Cadherin与肿瘤分化和淋巴结转移密切相关（P < 0.05）。Kaplan-Meier曲线显示，SNAIL的表达与DFS相关（P＜0.05），TWIST的表达与OS相关（P＜0.05）。肿瘤分化、淋巴结转移和TWIST表达是AGC患者预后不依赖的危险因素（P < 0.05）：结论：胃癌的发生、发展及TDs的形成可能与EMT有关，分析EMT相关转化蛋白的表达有助于判断胃癌的预后。

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来源期刊

Indian Journal of Pathology and Microbiology PATHOLOGY-

CiteScore

1.20

自引率

0.00%

发文量

422

审稿时长

1 months

期刊介绍： The journal will cover studies related to pathology including morbid anatomy, surgical pathology, clinical pathology, diagnostic cytopathology including gynecologic cytology and aspiration cytology, hematology including immuno-hematology and medical microbiology. The journal gives preference to clinically oriented studies over experimental and animal studies. The Journal would publish peer-reviewed original research papers, case reports, systematic reviews, meta-analysis, letters to the editor and brief communications. Review articles on current topics usually are invited by the editor.