Evaluation of “Indigenous Vaccine” Developed Using “Indian Bison Type” Genotype of Mycobacterium avium subspecies paratuberculosis Strain “S5” of Goat Origin in a Sheep Flock Endemic for Johne’s Disease: A Three Years Trial in India

Shoorvir V. Singh, A. Singh, P. Singh, Saurabh Gupta, H. Singh, Brajesh K. Singh, O. R. V. Kumar, A. S. Rajendiran, N. Swain, J. Sohal
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引用次数: 13

Abstract

“Indigenous vaccine” developed from native “Indian Bison Type” strain (“S5”) of Mycobacterium avium subspecies paratuberculosis (MAP) of “goat origin” was first time evaluated in a sheep flock of Bharat Merino breed located in Mannavanur town of Tamil Nadu in South India. Therapeutic efficacy of the vaccine was evaluated for 3 years between 2008 and 2010, on the basis of improvements in productivity (body weights, reproductive efficiency and survivability), physical condition, clinical symptoms (weakness, diarrhea, wool quality), immune response (sero-conversion) and infection load in feces (shedding). After immunization of the flock in 2008, the successive progenies of 112 and 53 lambs born in 2009 and 2010, respectively were vaccinated. Whereas, 40 lambs born to control animals were kept as unvaccinated controls. Though gain in body weights in vaccinated versus controls were not significant in 2008, growth rates were distinctly superior in Ist and IInd generations of vaccinated lambs. Reproductive performance (tupping percent) and survivability of lambs and adult sheep improved significantly. There was overall reduction in yearly morbidity (diarrhea) and mortality rates of the flock in post vaccination years. Shedding of MAP in feces was reduced in vaccinated sheep by 6.2%, 14.3% and 27.3% in 2008, 2009 and 2010 respectively, whereas shedding increased in the control sheep. Seromonitoring of the animals by “indigenous ELISA kit” showed enhanced “flock immunity” in successive generations. “Indigenous vaccine” reduced clinical disease and shedding and improved immunity and productivity of Bharat Merino flock, endemic for Johne’s disease.
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利用山羊源禽分枝杆菌亚种副结核毒株“S5”的“印度野牛型”基因型在一群羊约翰氏病地方性流行中开发的“本土疫苗”的评价:在印度进行的三年试验
从“山羊源”禽分枝杆菌亚种副结核(MAP)的本地“印度野牛型”毒株(“S5”)开发的“本地疫苗”首次在印度南部泰米尔纳德邦Mannavanur镇的巴拉特美利奴羊群中进行了评估。根据生产力(体重、繁殖效率和存活率)、身体状况、临床症状(虚弱、腹泻、羊毛质量)、免疫反应(血清转化)和粪便感染负荷(脱落)的改善,在2008年至2010年期间对疫苗的治疗效果进行了评估。在2008年对羊群进行免疫接种后,分别对2009年和2010年出生的112只和53只羊羔的连续后代接种了疫苗。然而,40只为对照动物出生的羔羊被保留为未接种疫苗的对照动物。虽然2008年接种疫苗的羔羊体重增加不明显,但第1代和第2代接种疫苗的羔羊的生长速度明显优于对照组。羔羊和成羊的繁殖性能和成活率均有显著提高。在接种疫苗后的几年里,鸡群的年发病率(腹泻)和死亡率总体上有所下降。2008年、2009年和2010年,接种疫苗的绵羊粪便中MAP的脱落量分别减少了6.2%、14.3%和27.3%,而对照组绵羊的脱落量则增加了。用“本地ELISA试剂盒”对动物进行血清监测,结果显示连续几代动物的“群体免疫力”增强。“本土疫苗”减少了临床疾病和脱落,提高了约翰氏病流行的巴拉特美利奴羊群的免疫力和生产力。
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