Static autoregulation in humans.

IF 4.9 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM Journal of Cerebral Blood Flow and Metabolism Pub Date : 2024-11-01 Epub Date: 2023-11-07 DOI:10.1177/0271678X231210430
Yufan Wang, Stephen J Payne
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Abstract

The process by which cerebral blood flow (CBF) remains approximately constant in response to short-term variations in arterial blood pressure (ABP) is known as cerebral autoregulation. This classic view, that it remains constant over a wide range of ABP, has however been challenged by a growing number of studies. To provide an updated understanding of the static cerebral pressure-flow relationship and to characterise the autoregulation curve more rigorously, we conducted a comprehensive literature research. Results were based on 143 studies in healthy individuals aged 18 to 65 years. The mean sensitivities of CBF to changes in ABP were found to be 1.47 ± 0.71%/% for decreased ABP and 0.37 ± 0.38%/% for increased ABP. The significant difference in CBF directional sensitivity suggests that cerebral autoregulation appears to be more effective in buffering increases in ABP than decreases in ABP. Regression analysis of absolute CBF and ABP identified an autoregulatory plateau of approximately 20 mmHg (ABP between 80 and 100 mmHg), which is much smaller than the widely accepted classical view. Age and sex were found to have no effect on autoregulation strength. This data-driven approach provides a quantitative method of analysing static autoregulation that can be easily updated as more experimental data become available.

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人类的静态自我调节。
大脑血流量(CBF)对动脉血压(ABP)的短期变化保持大致恒定的过程被称为大脑自动调节。然而,越来越多的研究对这一经典观点提出了质疑,即它在广泛的ABP中保持不变。为了提供对静态脑压-流量关系的最新理解,并更严格地描述自动调节曲线,我们进行了一项全面的文献研究。结果基于143项针对18至65岁健康人的研究 年。CBF对ABP变化的平均敏感性为1.47 ± ABP降低为0.71%/% ± ABP增加0.38%/%。CBF方向敏感性的显著差异表明,大脑自动调节在缓冲ABP增加方面似乎比ABP减少更有效。绝对CBF和ABP的回归分析确定了大约20的自动调节平台 mmHg(ABP在80和100之间 mmHg),这比广泛接受的经典观点小得多。年龄和性别对自身调节强度没有影响。这种数据驱动的方法提供了一种分析静态自动调节的定量方法,随着更多实验数据的可用,该方法可以很容易地更新。
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来源期刊
Journal of Cerebral Blood Flow and Metabolism
Journal of Cerebral Blood Flow and Metabolism 医学-内分泌学与代谢
CiteScore
12.00
自引率
4.80%
发文量
300
审稿时长
3 months
期刊介绍: JCBFM is the official journal of the International Society for Cerebral Blood Flow & Metabolism, which is committed to publishing high quality, independently peer-reviewed research and review material. JCBFM stands at the interface between basic and clinical neurovascular research, and features timely and relevant research highlighting experimental, theoretical, and clinical aspects of brain circulation, metabolism and imaging. The journal is relevant to any physician or scientist with an interest in brain function, cerebrovascular disease, cerebral vascular regulation and brain metabolism, including neurologists, neurochemists, physiologists, pharmacologists, anesthesiologists, neuroradiologists, neurosurgeons, neuropathologists and neuroscientists.
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