{"title":"Malaria Vaccine Development: Challenges and Prospects","authors":"E. Etefia, Paul Inyang- Etoh","doi":"10.55940/medphar202225","DOIUrl":null,"url":null,"abstract":"Background: The development of a licensed malaria vaccine has been challenging due to the complex multi-stage life cycle, antigenic variation, and genetic diversity of Plasmodium. Numerous vaccines have been developed for various stages of Plasmodium, including pre-erythrocytic, blood stage, placenta, and transmission-blocking vaccines. However, none of these vaccines are completely effective and have high reactogenicity.Aim: The aim of this review is to examine the challenges and prospects in developing an effective malaria vaccine, with a focus on the development of a multi-stage or multivalent malaria vaccine.Materials and Methods: The authors conducted a review of the literature on malaria vaccine development, focusing on the challenges and prospects of developing an effective malaria vaccine.Results: Efforts are underway to develop a multi-stage or multivalent malaria vaccine (MultiMalVax) that may best target sporozoite development and neutralize merozoites, hepatocytes, and erythrocytes. A thorough understanding of potential vaccine targets and how immunity works is critical to developing a fully effective malaria vaccine.Conclusion: The challenges associated with developing an effective malaria vaccine are significant due to the complex nature of the Plasmodium life cycle. However, the development of a multi-stage or multivalent malaria vaccine offers prospects for overcoming these challenges and developing a fully effective malaria vaccine. A better understanding of potential vaccine targets and how immunity works is crucial in developing an effective vaccine against malaria.","PeriodicalId":7822,"journal":{"name":"安徽医药","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"安徽医药","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.55940/medphar202225","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Background: The development of a licensed malaria vaccine has been challenging due to the complex multi-stage life cycle, antigenic variation, and genetic diversity of Plasmodium. Numerous vaccines have been developed for various stages of Plasmodium, including pre-erythrocytic, blood stage, placenta, and transmission-blocking vaccines. However, none of these vaccines are completely effective and have high reactogenicity.Aim: The aim of this review is to examine the challenges and prospects in developing an effective malaria vaccine, with a focus on the development of a multi-stage or multivalent malaria vaccine.Materials and Methods: The authors conducted a review of the literature on malaria vaccine development, focusing on the challenges and prospects of developing an effective malaria vaccine.Results: Efforts are underway to develop a multi-stage or multivalent malaria vaccine (MultiMalVax) that may best target sporozoite development and neutralize merozoites, hepatocytes, and erythrocytes. A thorough understanding of potential vaccine targets and how immunity works is critical to developing a fully effective malaria vaccine.Conclusion: The challenges associated with developing an effective malaria vaccine are significant due to the complex nature of the Plasmodium life cycle. However, the development of a multi-stage or multivalent malaria vaccine offers prospects for overcoming these challenges and developing a fully effective malaria vaccine. A better understanding of potential vaccine targets and how immunity works is crucial in developing an effective vaccine against malaria.