Potential anti-osteoporotic effect of Allolobophora caliginosa extract in orchiectomized rats

Q4 Pharmacology, Toxicology and Pharmaceutics Pharmaceutical Sciences Asia Pub Date : 2022-01-01 DOI:10.29090/psa.2022.02.21.144

Ayat Yousse, A. Baiomy, S. Fahmy, A. Mohamed, D. Saad, Reham Desoky

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引用次数: 2

Abstract

Osteoporosis is defined as a universal skeletal disorder. The medicinal importance of earthworms has been known from time immemorial. The present investigation was designed to assess the antiosteoporotic efficacy of the earthworm, Allolobophora caliginosa extract (AcE) in bilaterally orchiectomized rats (OCX) to elicit the underlying in vivo mechanism. Twenty-eight male rats were divided into two groups. The first group (7 rats/group) represented sham-operated rats, while the second group (21 rats/group) underwent bilateral orchidectomy (OCX). The second group was randomly subdivided into three subgroups; OCX and A. caliginosa extract (AcE) (100 or 200 mg/kg body weight/day) treated subgroup. Administration of AcE to OCX rats increased femoral bone mineral density (BMD), bone mineral content (BMC), calcium (Ca), phosphorus (P), and calcitonin level, as compared to OCX rats. On the other hand, administration of AcE to OCX rats significantly decreased serum alkaline phosphatase (ALP) activity and parathyroid hormone (PTH) level compared to OCX rats. The present study showed that AcE is a beneficial novel natural antiresorptive agent. Its anti-osteoporotic effects may positively impact osteoblast differentiation, particularly bone mineralization, and higher osteoblast activity account for bone formation, preventing osteoporosis.

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异叶参提取物对去睾丸大鼠的潜在抗骨质疏松作用

骨质疏松症是一种普遍的骨骼疾病。蚯蚓的药用价值自古以来就为人所知。本研究旨在探讨蚯蚓Allolobophora caliginosa提取物(AcE)对双侧睾丸切除大鼠(OCX)的抗骨质疏松作用，探讨其体内机制。28只雄性大鼠被分成两组。第一组为假手术大鼠(7只/组)，第二组为双侧睾丸切除术(OCX)大鼠(21只/组)。第二组随机分为三个亚组;OCX和caliginosa提取物(AcE)(100或200 mg/kg体重/天)处理亚组。与OCX大鼠相比，给药AcE增加了OCX大鼠股骨骨矿物质密度(BMD)、骨矿物质含量(BMC)、钙(Ca)、磷(P)和降钙素水平。另一方面，与OCX大鼠相比，给药AcE可显著降低血清碱性磷酸酶(ALP)活性和甲状旁腺激素(PTH)水平。本研究表明AcE是一种有益的新型天然抗吸收剂。其抗骨质疏松作用可能积极影响成骨细胞分化，特别是骨矿化，较高的成骨细胞活性解释骨形成，预防骨质疏松症。

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来源期刊

Pharmaceutical Sciences Asia Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)

CiteScore

0.90

自引率

0.00%

发文量

期刊介绍： The Pharmaceutical Sciences Asia (PSA) journal is a double-blinded peer-reviewed journal in English published quarterly, by the Faculty of Pharmacy, Mahidol University, Thailand. The PSA journal is formerly known as Mahidol University Journal of Pharmaceutical Sciences and committed to the timely publication of innovative articles and reviews. This journal is available in both printed and electronic formats. The PSA journal aims at establishing a publishing house that is open to all. It aims to disseminate knowledge; provide a learned reference in the field; and establish channels of communication between academic and research expert, policy makers and executives in industry and investment institutions. The journal publishes research articles, review articles, and scientific commentaries on all aspects of the pharmaceutical sciences and multidisciplinary field in health professions and medicine. More specifically, the journal publishes research on all areas of pharmaceutical sciences and related disciplines: Clinical Pharmacy Drug Synthesis and Discovery Targeted-Drug Delivery Pharmaceutics Biopharmaceutical Sciences Phytopharmaceutical Sciences Pharmacology and Toxicology Pharmaceutical Chemistry Nutraceuticals and Functional Foods Natural Products Social, Economic, and Administrative Pharmacy Clinical Drug Evaluation and Drug Policy Making Antimicrobials, Resistance and Infection Control Pharmacokinetics and Pharmacodynamics.