Skin Response During Irradiation by Intense Pulsed Light Based on Optical Imaging Technology and Histology

Shulian Wu, Hui Li, Zheng-ying Xiao, Zhifang Li
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引用次数: 1

Abstract

Nonablative light is a novel light source such as intense pulsed light (IPL) treatment for skin disease. The clinical objective of it is to maximize thermal damage to upper dermis while minimizing injury to the epidermis and to decrease potential complications. But many the complications also exist in the clinic. In this study, we developed a new approach to monitor the response of skin tissue irradiated by IPL and measured the attenuation coefficient between the change of the tissue optical properties utilizing fiber based on optical coherence tomography(OCT) technology and conventional histology. OCT is a well-established optical imaging technique that uses low coherence interferometry to produce micrometer-scale resolution images of biological media. The outcome shows that the attenuation coefficient increase after irradiated and then gradually reduces with times; the changes of the total attenuation coefficient increase with the dose.
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基于光学成像技术和组织学的强脉冲光照射下皮肤反应
非烧蚀光是一种新型光源,如强脉冲光(IPL)治疗皮肤病。临床目的是最大限度地热损伤上真皮层,同时尽量减少对表皮的损伤,并减少潜在的并发症。但许多并发症也存在于临床。在这项研究中,我们开发了一种新的方法来监测皮肤组织在IPL照射下的响应,并利用光纤光学相干断层扫描(OCT)技术测量了组织光学特性变化与传统组织学之间的衰减系数。OCT是一种成熟的光学成像技术,它使用低相干干涉术来产生微米级分辨率的生物介质图像。结果表明:辐照后衰减系数先增大,然后随辐照次数的增加逐渐减小;总衰减系数随剂量增大而增大。
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