Pub Date : 2009-10-30DOI: 10.1109/BMEI.2009.5305558
Y. Mao, Jianmei Xu, L. Bai, Jiantao Niu, Jiwen Yang, Xiaoyan Tan
In order to analyze the relationship between time series of the blood flow that has been measured in a small area of tissue and patterns of the blood flow fluctuations in the capillary unit, the autocorrelation coefficient model was established to characterize the continuity of blood flow based on the theory of autocorrelation coefficient. And it's proved that if we take blood flow of a local tissue as a clustered sequences, which are made up of a number of capillary units with the same pseudo cycle and different phases, the sequence of microcirculation blood flow and the capillary unit have the same cycle fluctuations. Measured the blood flow of the human biceps in resting, denoised the signals through wavelet tranform, and derived the spectrum and pseudo cycle by Matlab. The character of blood flow fluctuations in a capillary unit can thus be estimated, which provided an effective way to find out character of the blood flow in the capillary unit.
{"title":"Analysis on the Cyclical Fluctuations of the Blood Flow in the Microcirculation","authors":"Y. Mao, Jianmei Xu, L. Bai, Jiantao Niu, Jiwen Yang, Xiaoyan Tan","doi":"10.1109/BMEI.2009.5305558","DOIUrl":"https://doi.org/10.1109/BMEI.2009.5305558","url":null,"abstract":"In order to analyze the relationship between time series of the blood flow that has been measured in a small area of tissue and patterns of the blood flow fluctuations in the capillary unit, the autocorrelation coefficient model was established to characterize the continuity of blood flow based on the theory of autocorrelation coefficient. And it's proved that if we take blood flow of a local tissue as a clustered sequences, which are made up of a number of capillary units with the same pseudo cycle and different phases, the sequence of microcirculation blood flow and the capillary unit have the same cycle fluctuations. Measured the blood flow of the human biceps in resting, denoised the signals through wavelet tranform, and derived the spectrum and pseudo cycle by Matlab. The character of blood flow fluctuations in a capillary unit can thus be estimated, which provided an effective way to find out character of the blood flow in the capillary unit.","PeriodicalId":6389,"journal":{"name":"2009 2nd International Conference on Biomedical Engineering and Informatics","volume":"75 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2009-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73907681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-10-30DOI: 10.1109/BMEI.2009.5305358
Yi-fei Zhu, Shi-ying Zheng, J. Ge, Jun Zhao, D. Jiang
AIM: To evaluate the role of survivin and caspase-3 in apoptosis of gastric carcinoma, as well as in prognosis of patients with gastric carcinoma. METHODS: Expressions of survivin and caspase-3 were investigated immunohistochemically in 80 gastric carcinoma patients without a history of chemo-radiation therapy. Tumor cell apoptosis was examined by TUNEL method. RESULTS: Immunohistochemical analysis showed that survivin expression was positive in 61 of 80 patients (76%) with gastric carcinoma. In contrast, no expression of survivin in adjacent normal tissues was detected. Expression level of caspase-3 was higher in normal tissues than in carcinoma. Patients with higher expression of survivin had worse histological grades and pathological stages. Expression of caspase-3 was significantly associated with histological stages, but not with the pathological stages. Although survivin expression in carcinoma was not inversely related to caspase-3, patients with survivin (-) and caspase-3(+) had the maximum apoptosis index. CONCLUSION: Expression level of survivin was associated with histological grades and pathological stages of the tumor, indicating that survivin may be a poor prognosis factor for gastric carcinoma. Unlike caspase-3, survivin
{"title":"Influence of Survivin and Caspase-3 on Cell Apoptosis and Prognosis in Gastric Carcinoma","authors":"Yi-fei Zhu, Shi-ying Zheng, J. Ge, Jun Zhao, D. Jiang","doi":"10.1109/BMEI.2009.5305358","DOIUrl":"https://doi.org/10.1109/BMEI.2009.5305358","url":null,"abstract":"AIM: To evaluate the role of survivin and caspase-3 in apoptosis of gastric carcinoma, as well as in prognosis of patients with gastric carcinoma. METHODS: Expressions of survivin and caspase-3 were investigated immunohistochemically in 80 gastric carcinoma patients without a history of chemo-radiation therapy. Tumor cell apoptosis was examined by TUNEL method. RESULTS: Immunohistochemical analysis showed that survivin expression was positive in 61 of 80 patients (76%) with gastric carcinoma. In contrast, no expression of survivin in adjacent normal tissues was detected. Expression level of caspase-3 was higher in normal tissues than in carcinoma. Patients with higher expression of survivin had worse histological grades and pathological stages. Expression of caspase-3 was significantly associated with histological stages, but not with the pathological stages. Although survivin expression in carcinoma was not inversely related to caspase-3, patients with survivin (-) and caspase-3(+) had the maximum apoptosis index. CONCLUSION: Expression level of survivin was associated with histological grades and pathological stages of the tumor, indicating that survivin may be a poor prognosis factor for gastric carcinoma. Unlike caspase-3, survivin","PeriodicalId":6389,"journal":{"name":"2009 2nd International Conference on Biomedical Engineering and Informatics","volume":"89 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2009-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74716715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-10-30DOI: 10.1109/BMEI.2009.5305603
Li Liu, Jing Tang, Song-zhan Li
A new and non-invasive method adapted for optical diagnosis of early caries is proposed by researching on the interaction mechanism of laser with dental tissue and relations of remitted light with optical properties of the tissue. This method without light filter, differed from the DIAGNodent ® and PNC method in its ability for registering fluorescence spectrum. The characteristic spectrum of dental tissue contains rich information about caries components, structure, spatial conformation, and so on. The research was conducted in vitro, and three components of characteristic spectrum are analyzed: backscattering, reflection and auto-fluorescence. It enables not only to evaluate chemical changes in tooth by analyzing characteristic frequencies of auto-fluorescence spectrum, but also to estimate structure and morphological changes in tissue by means of anti-stokes fluorescence spectrum. Preliminary results show that this method has a potential application in the quantitive diagnosis of various stages of dental caries and high sensitivity for detecting early caries and the surface damage of health enamel. Dental caries is oral disease with high incidence caused by bacterial infection, which seriously endangers human health. Conventional procedures for caries detection are unable to detect the lesions until they are well advanced and involve about one-third of the thickness of enamel. The problem of early caries lesions formation and development is still present for scientific debates. The first sign of the caries demineralization is concerned with the increase of microporosity of enamel. Additionally it is known that caries process is periodic and with the increased penetration of acids. It is possible to eliminate micro-lesions of crystalline structure of enamel by controlling environmental factors of oral cavity. Total reconstruction of tooth tissue is possible only in very early stage. A caries diagnosis method by detecting fluorescence spectrum including backscattering, back-reflected and auto- fluorescence is proposed, which is more sensitive to detect early caries, surface damage of health enamel. II. CARIES PROCESS It is generally recognized that that the caries process results from a shift in the oral equilibrium favoring demineralization over re-mineralization for a prolonged period of time. Thus, the body's natural defense mechanisms are simply unable to repair the damage at the same rate that demineralization continues to occur. Eventually, an "incipient" caries lesion is detected as a so-called "white spot". An examination of this stage of the lesion reveals a thin layer of partially-dematerialized enamel covering a large de-mineralized area. Caries occurs regardless of the type of tooth surface, the age of the host or whether the tooth is deciduous or permanent. It is also known that re- mineralization of these lesions at this stage can only occur as long as the thin layer of enamel remains intact over the lesion; if the surface layer is
{"title":"A New Method for Caries Diagnosis by Characteristic Spectrum","authors":"Li Liu, Jing Tang, Song-zhan Li","doi":"10.1109/BMEI.2009.5305603","DOIUrl":"https://doi.org/10.1109/BMEI.2009.5305603","url":null,"abstract":"A new and non-invasive method adapted for optical diagnosis of early caries is proposed by researching on the interaction mechanism of laser with dental tissue and relations of remitted light with optical properties of the tissue. This method without light filter, differed from the DIAGNodent ® and PNC method in its ability for registering fluorescence spectrum. The characteristic spectrum of dental tissue contains rich information about caries components, structure, spatial conformation, and so on. The research was conducted in vitro, and three components of characteristic spectrum are analyzed: backscattering, reflection and auto-fluorescence. It enables not only to evaluate chemical changes in tooth by analyzing characteristic frequencies of auto-fluorescence spectrum, but also to estimate structure and morphological changes in tissue by means of anti-stokes fluorescence spectrum. Preliminary results show that this method has a potential application in the quantitive diagnosis of various stages of dental caries and high sensitivity for detecting early caries and the surface damage of health enamel. Dental caries is oral disease with high incidence caused by bacterial infection, which seriously endangers human health. Conventional procedures for caries detection are unable to detect the lesions until they are well advanced and involve about one-third of the thickness of enamel. The problem of early caries lesions formation and development is still present for scientific debates. The first sign of the caries demineralization is concerned with the increase of microporosity of enamel. Additionally it is known that caries process is periodic and with the increased penetration of acids. It is possible to eliminate micro-lesions of crystalline structure of enamel by controlling environmental factors of oral cavity. Total reconstruction of tooth tissue is possible only in very early stage. A caries diagnosis method by detecting fluorescence spectrum including backscattering, back-reflected and auto- fluorescence is proposed, which is more sensitive to detect early caries, surface damage of health enamel. II. CARIES PROCESS It is generally recognized that that the caries process results from a shift in the oral equilibrium favoring demineralization over re-mineralization for a prolonged period of time. Thus, the body's natural defense mechanisms are simply unable to repair the damage at the same rate that demineralization continues to occur. Eventually, an \"incipient\" caries lesion is detected as a so-called \"white spot\". An examination of this stage of the lesion reveals a thin layer of partially-dematerialized enamel covering a large de-mineralized area. Caries occurs regardless of the type of tooth surface, the age of the host or whether the tooth is deciduous or permanent. It is also known that re- mineralization of these lesions at this stage can only occur as long as the thin layer of enamel remains intact over the lesion; if the surface layer is","PeriodicalId":6389,"journal":{"name":"2009 2nd International Conference on Biomedical Engineering and Informatics","volume":"32 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2009-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74918514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-10-30DOI: 10.1109/BMEI.2009.5305663
K. Yeh, Yeh-Cheng Chen, Chia-Chen Chen, Ruey-Shun Chen
Due to the aging population society coming, more and more families need the in-time service of medical care for the elderly. For creating a healthy and safety living environment, this study is applied to the radio frequency identification (RFID) and the software agent technology to develop the Pervasive Health Service Grid. This framework is based on the grid architecture to provide patients health service at home environment. Furthermore, we also construct a platform with mobile mechanism to fulfill the requirements of personal health care. This study will be helpful to establish the personal medical treatment environment, and enhance the service quality of health care. Keywords-RFID; Software Agent; Pervasive Health Service
{"title":"An RFID-Based Software Agent Framework on Pervasive Health Service","authors":"K. Yeh, Yeh-Cheng Chen, Chia-Chen Chen, Ruey-Shun Chen","doi":"10.1109/BMEI.2009.5305663","DOIUrl":"https://doi.org/10.1109/BMEI.2009.5305663","url":null,"abstract":"Due to the aging population society coming, more and more families need the in-time service of medical care for the elderly. For creating a healthy and safety living environment, this study is applied to the radio frequency identification (RFID) and the software agent technology to develop the Pervasive Health Service Grid. This framework is based on the grid architecture to provide patients health service at home environment. Furthermore, we also construct a platform with mobile mechanism to fulfill the requirements of personal health care. This study will be helpful to establish the personal medical treatment environment, and enhance the service quality of health care. Keywords-RFID; Software Agent; Pervasive Health Service","PeriodicalId":6389,"journal":{"name":"2009 2nd International Conference on Biomedical Engineering and Informatics","volume":"40 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2009-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73220382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-10-30DOI: 10.1109/BMEI.2009.5305466
Qin Gong, Yanru Hu, Y. Cu, Tian Guan, Cheng Peng
In order to diagnose and locate the defected site of two main sensorineural hearing loss which were cochlear hearing loss and retrocochlear hearing loss, a technique that based on AR spectrum analysis for the signals of Transient Evoked Otoacoustic Emissions (TEOAE) and TEOAE suppressed by Contralateral Acoustic Stimulation (CAS) was proposed. Firstly, normal ranges of the two curves which reflecting the information of relationship of TEOAE's logarithm AR spectrum with frequency and the relationship of the suppressed TEOAE's logarithm AR spectrum with frequency for the normal hearing ears were obtained. Then the subject's logarithm AR spectrum with frequency and the suppressed logarithm AR spectrum with frequency curves were compared with the two normal-hearing curves' range respectively. The sensorineural hearing loss disease could be diagnosed and the defected site could be further located. A comparison was made between this technique and other clinical integration methods, and results were comparatively consistent.
{"title":"Clinical Application and AR Spectrum Analysis of Transient Evoked Otoacoustic Emission with or without Contralateral Acoustic Stimulation","authors":"Qin Gong, Yanru Hu, Y. Cu, Tian Guan, Cheng Peng","doi":"10.1109/BMEI.2009.5305466","DOIUrl":"https://doi.org/10.1109/BMEI.2009.5305466","url":null,"abstract":"In order to diagnose and locate the defected site of two main sensorineural hearing loss which were cochlear hearing loss and retrocochlear hearing loss, a technique that based on AR spectrum analysis for the signals of Transient Evoked Otoacoustic Emissions (TEOAE) and TEOAE suppressed by Contralateral Acoustic Stimulation (CAS) was proposed. Firstly, normal ranges of the two curves which reflecting the information of relationship of TEOAE's logarithm AR spectrum with frequency and the relationship of the suppressed TEOAE's logarithm AR spectrum with frequency for the normal hearing ears were obtained. Then the subject's logarithm AR spectrum with frequency and the suppressed logarithm AR spectrum with frequency curves were compared with the two normal-hearing curves' range respectively. The sensorineural hearing loss disease could be diagnosed and the defected site could be further located. A comparison was made between this technique and other clinical integration methods, and results were comparatively consistent.","PeriodicalId":6389,"journal":{"name":"2009 2nd International Conference on Biomedical Engineering and Informatics","volume":"41 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2009-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75576881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-10-30DOI: 10.1109/BMEI.2009.5305803
Di Zhang, Jiazhong He, Jianping Yao, Zhongkai Wu, Minghui Du
In this paper, the spectral features in recorded heart sounds with mechanical prosthetic heart valves were investigated using various spectral estimation techniques. Results showed that for patients with mechanical prosthetic heart valve, using only PSD techniques, it is possible to identify the normal and abnormal patients, as well as classify perivalvular leakage, valve obstruction and stenosis-based malfunctions. Keywordsheart sounds, spectral analysis, prosthetic heart valve malfunction
{"title":"Spectral Analysis of Heart Sounds Produced by Disorder Mechanical Prosthetic Heart Valves","authors":"Di Zhang, Jiazhong He, Jianping Yao, Zhongkai Wu, Minghui Du","doi":"10.1109/BMEI.2009.5305803","DOIUrl":"https://doi.org/10.1109/BMEI.2009.5305803","url":null,"abstract":"In this paper, the spectral features in recorded heart sounds with mechanical prosthetic heart valves were investigated using various spectral estimation techniques. Results showed that for patients with mechanical prosthetic heart valve, using only PSD techniques, it is possible to identify the normal and abnormal patients, as well as classify perivalvular leakage, valve obstruction and stenosis-based malfunctions. Keywordsheart sounds, spectral analysis, prosthetic heart valve malfunction","PeriodicalId":6389,"journal":{"name":"2009 2nd International Conference on Biomedical Engineering and Informatics","volume":"10 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2009-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78701210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-10-30DOI: 10.1109/BMEI.2009.5305546
Xiang Wang, Jianping Zhang, Yonghong Yan
Modern lifestyle has increased the risk of pathological voices problems. So the therapy of pathological people attracts more attention of people. Meanwhile, acoustic features have been used widely in the therapy of voice disordered people. Classification of Normal and Pathological people is also an auxiliary therapy operation. MFCC has been proved to be a useful feature with traditional classifier such as GMM or HMM. However, the precision rate of the classification can still be improved. In Pattern Recognition field, GMM-SVM has been an effective classification method. In this study, we found that this classification method is also effective in voice disorder classification. EER was improved from 8.2% of GMM to 6.0% of GMM-SVM. Keywords-Pathological voices, GMM, SVM
{"title":"Automatic Detection of Pathological Voices Using GMM-SVM Method","authors":"Xiang Wang, Jianping Zhang, Yonghong Yan","doi":"10.1109/BMEI.2009.5305546","DOIUrl":"https://doi.org/10.1109/BMEI.2009.5305546","url":null,"abstract":"Modern lifestyle has increased the risk of pathological voices problems. So the therapy of pathological people attracts more attention of people. Meanwhile, acoustic features have been used widely in the therapy of voice disordered people. Classification of Normal and Pathological people is also an auxiliary therapy operation. MFCC has been proved to be a useful feature with traditional classifier such as GMM or HMM. However, the precision rate of the classification can still be improved. In Pattern Recognition field, GMM-SVM has been an effective classification method. In this study, we found that this classification method is also effective in voice disorder classification. EER was improved from 8.2% of GMM to 6.0% of GMM-SVM. Keywords-Pathological voices, GMM, SVM","PeriodicalId":6389,"journal":{"name":"2009 2nd International Conference on Biomedical Engineering and Informatics","volume":"153 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2009-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78198125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-10-30DOI: 10.1109/BMEI.2009.5305871
Haizhu Chen, Xi Gao
Spiking neural P systems are a new computing model incorporating the ideas of spiking neurons into mem- brane computing. It has been shown that they have powerful computational capability and potential capability in solving computationally hard problems. The paper proved the possibility to perform transforming operations between decimal number and n-base number in spiking neural P system, and gave transforming models and an effective method to implement transforming operations. I. INTRODUCTION
{"title":"Decimal Transforming Operations in Spiking Neural P Systems","authors":"Haizhu Chen, Xi Gao","doi":"10.1109/BMEI.2009.5305871","DOIUrl":"https://doi.org/10.1109/BMEI.2009.5305871","url":null,"abstract":"Spiking neural P systems are a new computing model incorporating the ideas of spiking neurons into mem- brane computing. It has been shown that they have powerful computational capability and potential capability in solving computationally hard problems. The paper proved the possibility to perform transforming operations between decimal number and n-base number in spiking neural P system, and gave transforming models and an effective method to implement transforming operations. I. INTRODUCTION","PeriodicalId":6389,"journal":{"name":"2009 2nd International Conference on Biomedical Engineering and Informatics","volume":"40 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2009-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78506805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-10-30DOI: 10.1109/BMEI.2009.5304967
Chien-Yu Chen, D. Bau, M. Tsai, Y. Hsu, T. Ho, Hung-Jin Huang, Yea-Huey Chang, F. Tsai, Chang-Hai Tsai, Calvin Yu‐Chian Chen
# Equal contribution Abstract—This study could show that the potent inhibitor of PDE5 from Epimedium sagittatum components. The PDE 5 inhibitors of data set from Xia's study were calculated their properties. Multiple linear regression analysis was used to build the QSAR model. Those properties were associated to drug activities by the QSAR model. This result showed high correlation (R2 = 0.848) with drug activities in this QSAR model. The weights of those properties were -5.359, 6.434, -3.959, 5.149, and 8.689. In the result of prediction, the correlation was employed to predict pIC50 of the ES series (Cialis = 7.988, ES02 = 6.31, ES03a = 9.78, ES03b = 10.03). The docking protocol was used to prove the trend of prediction. This result showed the same trend in docking scores (Cialis = 53.271, ES02 = 57.864, ES03a = 64.260, ES03b = 76.915). According to those results, ES03b was elevated to be a potent inhibitor of PDE5.
{"title":"Could Traditional Chinese Medicine Used for Curing Erectile Dysfunction?","authors":"Chien-Yu Chen, D. Bau, M. Tsai, Y. Hsu, T. Ho, Hung-Jin Huang, Yea-Huey Chang, F. Tsai, Chang-Hai Tsai, Calvin Yu‐Chian Chen","doi":"10.1109/BMEI.2009.5304967","DOIUrl":"https://doi.org/10.1109/BMEI.2009.5304967","url":null,"abstract":"# Equal contribution Abstract—This study could show that the potent inhibitor of PDE5 from Epimedium sagittatum components. The PDE 5 inhibitors of data set from Xia's study were calculated their properties. Multiple linear regression analysis was used to build the QSAR model. Those properties were associated to drug activities by the QSAR model. This result showed high correlation (R2 = 0.848) with drug activities in this QSAR model. The weights of those properties were -5.359, 6.434, -3.959, 5.149, and 8.689. In the result of prediction, the correlation was employed to predict pIC50 of the ES series (Cialis = 7.988, ES02 = 6.31, ES03a = 9.78, ES03b = 10.03). The docking protocol was used to prove the trend of prediction. This result showed the same trend in docking scores (Cialis = 53.271, ES02 = 57.864, ES03a = 64.260, ES03b = 76.915). According to those results, ES03b was elevated to be a potent inhibitor of PDE5.","PeriodicalId":6389,"journal":{"name":"2009 2nd International Conference on Biomedical Engineering and Informatics","volume":"17 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2009-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75008539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-10-30DOI: 10.1109/BMEI.2009.5305797
Xiaolei Wang, Yue-ting Chen
With the development of information technology, databases, search engines and other information technologies have been widely adopted in the health care system. However, sharing of those information resources is impeded by the heterogeneity and distribution among the independently designed and maintained information resources. Aiming at this problem, we bring forward an Integration of Heterogeneous Databases based on semantic web ontology , which is proposed to draw and represent the common interests of specific groups of people, and hence provide more meaningful and exhaustive query results. As an instance, we developed a unified Child Psychiatry Neuroimaging Portal based on the medical database resources such as the Internet Brain Volume Database (IBVD), Pubmed and so on. A prototype is developed to show that this semantic based integration can work well. Keywordssemantic; ontology; neuroimaging, integration, heterogeneous databases
{"title":"Semantic Based Integration of Heterogeneous Databases","authors":"Xiaolei Wang, Yue-ting Chen","doi":"10.1109/BMEI.2009.5305797","DOIUrl":"https://doi.org/10.1109/BMEI.2009.5305797","url":null,"abstract":"With the development of information technology, databases, search engines and other information technologies have been widely adopted in the health care system. However, sharing of those information resources is impeded by the heterogeneity and distribution among the independently designed and maintained information resources. Aiming at this problem, we bring forward an Integration of Heterogeneous Databases based on semantic web ontology , which is proposed to draw and represent the common interests of specific groups of people, and hence provide more meaningful and exhaustive query results. As an instance, we developed a unified Child Psychiatry Neuroimaging Portal based on the medical database resources such as the Internet Brain Volume Database (IBVD), Pubmed and so on. A prototype is developed to show that this semantic based integration can work well. Keywordssemantic; ontology; neuroimaging, integration, heterogeneous databases","PeriodicalId":6389,"journal":{"name":"2009 2nd International Conference on Biomedical Engineering and Informatics","volume":"1 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2009-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77345524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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