In-situ generated biocompatible alginate actuators for flow control in microfluidics

J. Saez, M. Antoñana, J. Etxebarria, F. Benito‐Lopez
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引用次数: 1

Abstract

This abstract describes for the first time the use of alginate hydrogels as miniaturised valves in microfluidic devices. These biocompatible and biodegradable microvalves are in-situ generated, on demand, allowing for microfluidic flow control. The microfluidic devices were fabricated using the origami technique with seven layers of cyclic olefin copolymer (COP) and thermocompression bonding. They can be thermally actuated (ON/OFF) at mild temperatures, 37 °C, and chemically erased from the main channel using an ethylenediaminetetraacetic acid disodium salt dehydrated (EDTA) solution, ensuring the reusability of the whole device.
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微流体流动控制的原位生成生物相容性海藻酸盐致动器
这摘要描述了首次使用海藻酸盐水凝胶作为微型阀在微流体装置。这些生物相容性和可生物降解的微阀是现场生成的,根据需要,允许微流体流动控制。采用七层环烯烃共聚物(COP)和热压键合的折纸技术制备了微流控器件。它们可以在37°C的温和温度下热启动(ON/OFF),并使用乙二胺四乙酸二钠盐脱水(EDTA)溶液从主通道化学擦除,确保整个设备的可重复使用性。
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