Pubertal development of male offspring born to mothers of different ages with fetoplacental insufficiency

Abstract

Today, the problem of male infertility or poor reproductive health is very relevant around the world. The formation of the reproductive system begins in the womb, when all the organs and systems are formed. Fetoplacental insufficiency – a clinical syndrome caused by morpho logical and functional changes in the placenta, manifested by disorders of the fetus, growth and development. To date, it is not known how fetoplacental insufficiency in mothers affects the condition and functioning of the reproductive system in adult male offspring. The purpose of this scientific work was to investigate the development of puberty in males-offspring born to mothers of different age with fetoplacental insufficiency and to evaluate efficacy of base and combined drug therapy during pregnancy. Materials. Healthy, mature Vistar females-mothers of young (3–4 months) and mature (8–10 months) reproductive age have been used in the experiment. Modeling of fetoplacental insufficiency has been carried out by subcutaneous daily introduction of 50% tetrachlomethane oil solution in dose of 2ml/kg of body weight from 12 th to 18 th day of pregnancy. General body masses and sexual development have been researched. The samples of blood serum with the aim to evaluate estradiol, testosterone and progesterone hormones levels have been taken. Results. Discussion. In the study of the reproductive weight of males, no changes were found, but at the autopsy of not lowered into the scrotum (cryptorchidism), such rats were born to young mothers with feto placental insufficiency. Such changes occurred against the background of hormonal imbalance, which manifested itself in a decrease in total testosterone and, conversely, increased estradiol and progesterone. There was a lag in sexual development in animals born to mothers of two age groups with fetoplacental insufficiency. Pharmaceutical composition contributed to normal physiological sexual development in males born to mothers of mature reproductive age with fetoplacental insufficiency, in young females, pharmaceutical composition did not show any corrective effect on offspring as well as the comparison drug – Dipyridamole. Conclusions and prospects of further developments. Fetoplacental insufficiency affects the somato-sexual development of male offspring born to mothers of different reproductive ages, which is manifested in delayed puberty and imbalance of sex hormones (decreased testosterone in all animals and increased estrogen levels only in offspring born to reproductively young). Which in the future can lead to problems with the functioning of the reproductive system. In the application of the new pharmaceutical composition which is administered to correct abnormal condition of pregnancy and observed high levels of testosterone but not estradiol levels decrease high only in offspring born to young females, which subsequently led to the normal sexual development of males. The comparison drug Dipyridamole did not show a corrective effect in pubertal males. The prospect of further development is to study the effects of fetoplacental insufficiency on the reproductive system of mature male rats of offspring born to mothers of different reproduc tive ages. It is possible to develop specific approaches to the prevention of detected pathology.