Using domain decomposition and priority queue integration scheme to solve two-dimensional model of myocardium

Abstract

The two-dimensional propagation model based on the Luo-Rudy phase II membrane model is limited by its great computational cost. To reduce this cost and allow large realistic models the authors developed a new numerical method based on domain decomposition and priority queue integration scheme (DDPQ). The new method offers stable solutions with relative errors less than 1% and computation time saving by a factor of 10 to 20, allowing much larger models based on realistic membrane kinetics and realistic dimensions to simulate reentry, triggered activity and their interactions.