Isolation and optimization of catechins from Acacia catechu and its antioxidant and anti-ageing properties in vitro

Abstract

Catechin is a polyphenol antioxidant plant metabolite which extracted from A. catechu, a hot water extract of red heartwood of Acacia catechu Willd. It is evident from the literature survey that the catechin is a biologically important polyphenolic compound. Aging is a complex biological phenomenon, an inevitable process. Numerous studies have reported that continuous exposure to reactive oxygen species can stimulate skin aging and that excessive accumulation of fat can cause an impaired skin barrier and tissue structure alterations. Thus, the maintenance of antioxidant homeostasis and the suppression of adipose accumulation are important strategies for skin anti-aging. In our study, a fairly simple, but a unique process had developed the highly purified actives, Catechin , and to prove the synergistic applications of highly purified catechin with other novel anti-oxidants notably Ascorbic acid. In vitro studies performed with these compounds exhibited in anti-elastase assay.