Microsponge as Novel Drug Delivery System: A Review

Abstract

During the last few decades, pharmaceutical industry gave more importance to the controlled release of dosage forms like solid formulation, semi solid formulation, and topicalpreparation dueto efficacy and patient compliance. Normal topical preparations have some disadvantages like unpleasant odour, greasiness, and skin irritation reported in study cases. Also many topicalpreparations fail to reach the systemic circulation in sufficient amounts in few cases. This problem is achieved by the present formulation as microsponge in the areas of research. MDS is amicroscopic sphere capable of absorbing skin secretions, therefore reducing the oiliness of the skin. Microspongehaving particle size of 10-25 microns in diameter, have wide range of entrapmentof various ingredients in a single microsponges system and release them at desired rates.Microsponge is recent novel technique for control release and targetspecific drug delivery system. Microsponges are polymeric delivery system composed of porous microspheres. They are tiny sponge-like sphericalparticle with a large porous surface.Drug release in microsponge is done by the external stimuli like (pH, temperature, rubbing). It hasseveral advantageous over the other topical preparations are non allergenic, non toxic, non irritant, non mutagenic. Microsponges are designed to deliver apharmaceutical active ingredient efficiently at the minimum dose and alsoto enhance stability, reduce side effects and modify drug release.©2022iGlobal Research and PublishingFoundation. All rights reserved.