Synthesis of magnetite-silica-carbon quantum dot nanocomposites for melatonin drug delivery

A. Faeghinia, H. Nuranian, Mojtaba Eslami
{"title":"Synthesis of magnetite-silica-carbon quantum dot nanocomposites for melatonin drug delivery","authors":"A. Faeghinia, H. Nuranian, Mojtaba Eslami","doi":"10.53063/synsint.2023.32142","DOIUrl":null,"url":null,"abstract":"In targeted drug delivery, the drug is released at a specific and desired point and condition. In this research, magnetite cores (high saturation magnetization property (emu.g-159) were used to target the drug system. First, magnetite nanoparticles were synthesized by coprecipitation method from divalent and trivalent chloride salts of iron (FeCl2 and FeCl3), then mesoporous silicas (with a pore diameter of 13 nm) were formed by Stöber's method from the tetraethylorthosilicate (TEOS) silica source on magnetite cores in spheres form. After that, the carbon quantum dots were synthesized by hydrothermal method from citric acid and their surface was immobilized by dimethylamine which were placed in silica cavities by physical adsorption method. \nThe effective drug melatonin (6.46 mg of melatonin per 100 mg of the drug system) was also loaded on this system by physical absorption method and the release of this drug was carefully determined by the release from the dialysis bag in the simulated environment of blood and cancer tissue. the quantum gain of the system was determined to be about 40%. The results showed that the loading of melatonin drug and carbon quantum dots was done well on silica nanoparticles with magnetite cores, and this system releases 30% of the drug even under temperature conditions.","PeriodicalId":22113,"journal":{"name":"Synthesis and Sintering","volume":"30 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Synthesis and Sintering","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.53063/synsint.2023.32142","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

In targeted drug delivery, the drug is released at a specific and desired point and condition. In this research, magnetite cores (high saturation magnetization property (emu.g-159) were used to target the drug system. First, magnetite nanoparticles were synthesized by coprecipitation method from divalent and trivalent chloride salts of iron (FeCl2 and FeCl3), then mesoporous silicas (with a pore diameter of 13 nm) were formed by Stöber's method from the tetraethylorthosilicate (TEOS) silica source on magnetite cores in spheres form. After that, the carbon quantum dots were synthesized by hydrothermal method from citric acid and their surface was immobilized by dimethylamine which were placed in silica cavities by physical adsorption method. The effective drug melatonin (6.46 mg of melatonin per 100 mg of the drug system) was also loaded on this system by physical absorption method and the release of this drug was carefully determined by the release from the dialysis bag in the simulated environment of blood and cancer tissue. the quantum gain of the system was determined to be about 40%. The results showed that the loading of melatonin drug and carbon quantum dots was done well on silica nanoparticles with magnetite cores, and this system releases 30% of the drug even under temperature conditions.
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
用于褪黑素药物递送的磁铁矿-硅-碳量子点纳米复合材料的合成
在靶向给药中,药物在特定的和期望的点和条件下释放。本研究采用具有高饱和磁化特性的磁铁矿(emu.g-159)作为药物体系的靶材。首先,以二价和三价氯化铁(FeCl2和FeCl3)为原料,采用共沉淀法合成了磁铁矿纳米颗粒,然后以四乙基硅酸(TEOS)硅源为原料,采用Stöber法在磁铁矿岩心上制备了孔径为13 nm的介孔二氧化硅。然后,以柠檬酸为原料,用水热法制备碳量子点,用二甲胺固定碳量子点表面,用物理吸附法将碳量子点置于硅孔中。通过物理吸收法将有效药物褪黑素(每100 mg药物系统中含有6.46 mg褪黑素)加载到该系统中,并通过透析袋在模拟血液和癌组织环境中的释放来仔细测定该药物的释放。系统的量子增益约为40%。结果表明,在具有磁铁矿核的二氧化硅纳米颗粒上很好地负载了褪黑素药物和碳量子点,即使在温度条件下,该系统也能释放30%的药物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
3D-printed calcium magnesium silicates: A mini-review Solid-solution phase formation rules for high entropy alloys: A thermodynamic perspective A review of synthesis strategies for nickel cobaltite-based composites in supercapacitor applications Synthesis and doping of high-temperature resistant spinel nano pigments: A review Effects of die geometry and insulation on the energy and electrical parameters analyses of spark plasma sintered TiC ceramics
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1