Pub Date : 2024-03-29DOI: 10.53063/synsint.2024.41210
Aidin Doroudi, P. Mahapatra, Fatemeh Bakhshi
Calcium magnesium silicates (CMS) represent a class of minerals with diverse applications in fields ranging from geology to materials science. With the advent of additive manufacturing technologies, particularly 3D printing, novel opportunities have emerged for the synthesis and utilization of CMS-based materials. In this mini-review, we provide a through overview of recent advancements in the 3D printing of CMS compounds, including diopside (DPS), bredigite (BR), and akermanite (AKT). We discuss the synthesis methods, properties, and potential applications of 3D-printed CMS materials, with a focus on their role in biomedical applications. Furthermore, we highlight challenges and prospects in the field, emphasizing the importance of continued research and innovation in harnessing the full potential of 3D-printed CMS materials.
{"title":"3D-printed calcium magnesium silicates: A mini-review","authors":"Aidin Doroudi, P. Mahapatra, Fatemeh Bakhshi","doi":"10.53063/synsint.2024.41210","DOIUrl":"https://doi.org/10.53063/synsint.2024.41210","url":null,"abstract":"Calcium magnesium silicates (CMS) represent a class of minerals with diverse applications in fields ranging from geology to materials science. With the advent of additive manufacturing technologies, particularly 3D printing, novel opportunities have emerged for the synthesis and utilization of CMS-based materials. In this mini-review, we provide a through overview of recent advancements in the 3D printing of CMS compounds, including diopside (DPS), bredigite (BR), and akermanite (AKT). We discuss the synthesis methods, properties, and potential applications of 3D-printed CMS materials, with a focus on their role in biomedical applications. Furthermore, we highlight challenges and prospects in the field, emphasizing the importance of continued research and innovation in harnessing the full potential of 3D-printed CMS materials.","PeriodicalId":22113,"journal":{"name":"Synthesis and Sintering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140366626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-29DOI: 10.53063/synsint.2024.41192
Samaneh Mamnooni, Ehsan Borhani, Hassan Heydari
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{"title":"Solid-solution phase formation rules for high entropy alloys: A thermodynamic perspective","authors":"Samaneh Mamnooni, Ehsan Borhani, Hassan Heydari","doi":"10.53063/synsint.2024.41192","DOIUrl":"https://doi.org/10.53063/synsint.2024.41192","url":null,"abstract":"<jats:p>tem</jats:p>","PeriodicalId":22113,"journal":{"name":"Synthesis and Sintering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140366983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-26DOI: 10.53063/synsint.2024.41209
Yalda Tarpoudi Baheri, Amir Mahdi Homayounfard
Supercapacitors (SCs), known for their exceptional power and reasonably high energy densities, long lifespan, and lower production costs, have emerged as an ideal solution to meet the growing demand for various energy storage applications. The characteristics of supercapacitors are greatly influenced by means of the choice of electrode materials, developing novel electrode materials a focal point for extensive research in the field of high-performance supercapacitors. In recent years, NiCo2O4 has garnered increasing attention as a supercapacitor electrode material owing to its notable edges, including high theoretical capacity, low cost, abundant availability, and ease of synthesizing. However, the performance of NiCo2O4 is hindered by its low electrical conductivity and limited surface area, leading to significant capacity deterioration. Therefore, it is imperative to systematically and comprehensively summarize the advancements in comprehending and adjusting NiCo2O4-based electrodes from multiple perspectives. The present review primarily focuses on the synthetic approaches employed to produce NiCo2O4 nanomaterials with diverse morphologies for their application in supercapacitors. This review article provides a comprehensive overview of the synthesis approaches utilized for developing nickel cobaltite-based composites tailored for supercapacitor applications. Various synthesis methods, including sol-gel, hydrothermal, and co-precipitation techniques, are discussed in detail, emphasizing the importance of optimizing synthesis parameters to enhance the electrochemical performance of the composites. The potential applications of nickel cobaltite-based composites in supercapacitors are explored, highlighting their promising prospects in energy storage technologies. Future research directions in this field are also discussed.
{"title":"A review of synthesis strategies for nickel cobaltite-based composites in supercapacitor applications","authors":"Yalda Tarpoudi Baheri, Amir Mahdi Homayounfard","doi":"10.53063/synsint.2024.41209","DOIUrl":"https://doi.org/10.53063/synsint.2024.41209","url":null,"abstract":"Supercapacitors (SCs), known for their exceptional power and reasonably high energy densities, long lifespan, and lower production costs, have emerged as an ideal solution to meet the growing demand for various energy storage applications. The characteristics of supercapacitors are greatly influenced by means of the choice of electrode materials, developing novel electrode materials a focal point for extensive research in the field of high-performance supercapacitors. In recent years, NiCo2O4 has garnered increasing attention as a supercapacitor electrode material owing to its notable edges, including high theoretical capacity, low cost, abundant availability, and ease of synthesizing. However, the performance of NiCo2O4 is hindered by its low electrical conductivity and limited surface area, leading to significant capacity deterioration. Therefore, it is imperative to systematically and comprehensively summarize the advancements in comprehending and adjusting NiCo2O4-based electrodes from multiple perspectives. The present review primarily focuses on the synthetic approaches employed to produce NiCo2O4 nanomaterials with diverse morphologies for their application in supercapacitors. This review article provides a comprehensive overview of the synthesis approaches utilized for developing nickel cobaltite-based composites tailored for supercapacitor applications. Various synthesis methods, including sol-gel, hydrothermal, and co-precipitation techniques, are discussed in detail, emphasizing the importance of optimizing synthesis parameters to enhance the electrochemical performance of the composites. The potential applications of nickel cobaltite-based composites in supercapacitors are explored, highlighting their promising prospects in energy storage technologies. Future research directions in this field are also discussed.","PeriodicalId":22113,"journal":{"name":"Synthesis and Sintering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140379357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-24DOI: 10.53063/synsint.2024.41172
Milad Sakkaki, Milad Foroutani, Peyman Zare
This work conducts a numerical simulation to investigate the temperature and electric current distribution during the spark plasma sintering (SPS) process using the finite element method (FEM) carried out in COMSOL Multiphysics software. The main goal is to optimize the SPS process for titanium carbide (TiC) ceramics, with a particular focus on the effects of insulation and die geometry (height and thickness). For the TiC material, the ideal sintering temperature is set at 2000 °C. The study analyzes eight case studies, involving a base case, an insulating case, and six cases with various thicknesses and heights, in order to evaluate the effectiveness of the suggested optimization. The results show that using insulation on the die surface reduces heat transfer from the die surface significantly, which leads to a 63% decrease in input power consumption when compared to the basic scenario. Based on a correlation study between energy and electricity, increasing die thickness raises the cross-sectional area of the electric current, which raises the amount of electric power required to attain the 2000 °C sintering temperature. The results indicate the temperature distribution in the sample is more sensitive to changes in die height than to changes in die thickness.
{"title":"Effects of die geometry and insulation on the energy and electrical parameters analyses of spark plasma sintered TiC ceramics","authors":"Milad Sakkaki, Milad Foroutani, Peyman Zare","doi":"10.53063/synsint.2024.41172","DOIUrl":"https://doi.org/10.53063/synsint.2024.41172","url":null,"abstract":"This work conducts a numerical simulation to investigate the temperature and electric current distribution during the spark plasma sintering (SPS) process using the finite element method (FEM) carried out in COMSOL Multiphysics software. The main goal is to optimize the SPS process for titanium carbide (TiC) ceramics, with a particular focus on the effects of insulation and die geometry (height and thickness). For the TiC material, the ideal sintering temperature is set at 2000 °C. The study analyzes eight case studies, involving a base case, an insulating case, and six cases with various thicknesses and heights, in order to evaluate the effectiveness of the suggested optimization. The results show that using insulation on the die surface reduces heat transfer from the die surface significantly, which leads to a 63% decrease in input power consumption when compared to the basic scenario. Based on a correlation study between energy and electricity, increasing die thickness raises the cross-sectional area of the electric current, which raises the amount of electric power required to attain the 2000 °C sintering temperature. The results indicate the temperature distribution in the sample is more sensitive to changes in die height than to changes in die thickness.","PeriodicalId":22113,"journal":{"name":"Synthesis and Sintering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140385843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-24DOI: 10.53063/synsint.2024.41186
A. Faeghinia
In this study, the YAG silicate glasses containing the cerium sulfate and cerium oxide salts (17YO3-33Al2O3-40SiO2-2AlF3-3NaF-2CeO2-3B2O3), separately were produced by melting method and glass ceramics were produced by heat treatment of base glasses. According to Photo Luminescence spectrums of both glasses there were emissions in the range of 466 and 435 nm wavelengths related to cerium ions. It was shown that by heating treatment, garnet crystal (in sulfated sample) formed less than the sample with cerium oxide. The emission spectra of both glass-ceramics, when excited at 240 nm, fall within the wavelength range of 460 nm. Also, the 534 and 660 nm emissions wavelengths were obtained by 340 nm wavelength excitation. Heat treatments were done by oxide atmosphere in tubular furnace (single step), SPS sintered powder and in hydrogen atmosphere (by two steps heating). According to XRD results the 24 hrs. heat treating time and the 1060 °C temperature affect the entry of cerium into the garnet structure. Finally, by comparing the spectroscopic results the optical response of the garnet glass-ceramic synthesized in the hydrogen atmosphere was obtained at 400 nm wavelength that indicated this garnet can be applied in the LED industry.
{"title":"Effects of cerium oxide and cerium sulfate on the optical behavior of synthesized garnet glass ceramics","authors":"A. Faeghinia","doi":"10.53063/synsint.2024.41186","DOIUrl":"https://doi.org/10.53063/synsint.2024.41186","url":null,"abstract":"In this study, the YAG silicate glasses containing the cerium sulfate and cerium oxide salts (17YO3-33Al2O3-40SiO2-2AlF3-3NaF-2CeO2-3B2O3), separately were produced by melting method and glass ceramics were produced by heat treatment of base glasses. According to Photo Luminescence spectrums of both glasses there were emissions in the range of 466 and 435 nm wavelengths related to cerium ions. It was shown that by heating treatment, garnet crystal (in sulfated sample) formed less than the sample with cerium oxide. The emission spectra of both glass-ceramics, when excited at 240 nm, fall within the wavelength range of 460 nm. Also, the 534 and 660 nm emissions wavelengths were obtained by 340 nm wavelength excitation. Heat treatments were done by oxide atmosphere in tubular furnace (single step), SPS sintered powder and in hydrogen atmosphere (by two steps heating). According to XRD results the 24 hrs. heat treating time and the 1060 °C temperature affect the entry of cerium into the garnet structure. Finally, by comparing the spectroscopic results the optical response of the garnet glass-ceramic synthesized in the hydrogen atmosphere was obtained at 400 nm wavelength that indicated this garnet can be applied in the LED industry.","PeriodicalId":22113,"journal":{"name":"Synthesis and Sintering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140385899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Spinel nano-pigments are high-performance super small particles, combining the stable properties of the spinel structures with the high activity of Nanomaterials. While entrapment of highly toxic yet beautiful chromophores in the spinel structure diminishes the toxicity and improves the thermal resistance, a high surface area provided by the nano-scale pigments results in a uniform bright coating with a sufficiently high color strength and enhanced light transmission. Although the spinel nano pigments are promising for the coating and ceramic industries, the applications are limited, mostly due to the required high sintering temperature. Various synthesis processes have been tried for these pigments with the sol-gel method being the most frequent one. Many elements have been considered as dopants for these spinel systems to enhance, change, or improve the optical and physical properties. This comprehensive review aims to summarize the work done in this field, covering almost 20 years of research dedicated to the synthesis and doping of spinel nano pigments.
{"title":"Synthesis and doping of high-temperature resistant spinel nano pigments: A review","authors":"Rayehe Tavakolipour, Reza Pournajaf, Egle Grazenaite","doi":"10.53063/synsint.2024.41191","DOIUrl":"https://doi.org/10.53063/synsint.2024.41191","url":null,"abstract":"Spinel nano-pigments are high-performance super small particles, combining the stable properties of the spinel structures with the high activity of Nanomaterials. While entrapment of highly toxic yet beautiful chromophores in the spinel structure diminishes the toxicity and improves the thermal resistance, a high surface area provided by the nano-scale pigments results in a uniform bright coating with a sufficiently high color strength and enhanced light transmission. Although the spinel nano pigments are promising for the coating and ceramic industries, the applications are limited, mostly due to the required high sintering temperature. Various synthesis processes have been tried for these pigments with the sol-gel method being the most frequent one. Many elements have been considered as dopants for these spinel systems to enhance, change, or improve the optical and physical properties. This comprehensive review aims to summarize the work done in this field, covering almost 20 years of research dedicated to the synthesis and doping of spinel nano pigments.","PeriodicalId":22113,"journal":{"name":"Synthesis and Sintering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140385478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-23DOI: 10.53063/synsint.2024.41195
Mehdi Shahedi Asl
Serving as a member of the editorial board of Synthesis and Sintering and the founder of the Synsint Research Group is undoubtedly a great honor for me. I am happy to witness the significant growth of this journal as a global platform that publishes scientific articles with high standards. As we celebrate the third anniversary of Synthesis and Sintering, we are proud to present to readers a collection of high-quality articles written by leading experts and young researchers in the fields of synthesis and sintering. These articles, which have been published regularly in the past three years, have shown the commitment of the journal and its management team to the development of science and research in these fields. In this editorial article, the goals of the journal, its achievements and our prospects are presented.
{"title":"Editorial to celebrate the 3rd anniversary of Synthesis and Sintering","authors":"Mehdi Shahedi Asl","doi":"10.53063/synsint.2024.41195","DOIUrl":"https://doi.org/10.53063/synsint.2024.41195","url":null,"abstract":"Serving as a member of the editorial board of Synthesis and Sintering and the founder of the Synsint Research Group is undoubtedly a great honor for me. I am happy to witness the significant growth of this journal as a global platform that publishes scientific articles with high standards. As we celebrate the third anniversary of Synthesis and Sintering, we are proud to present to readers a collection of high-quality articles written by leading experts and young researchers in the fields of synthesis and sintering. These articles, which have been published regularly in the past three years, have shown the commitment of the journal and its management team to the development of science and research in these fields. In this editorial article, the goals of the journal, its achievements and our prospects are presented.","PeriodicalId":22113,"journal":{"name":"Synthesis and Sintering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140210490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-17DOI: 10.53063/synsint.2023.34178
Milad Sakkaki, Mohsen Naderi, M. Vajdi, Farhad Sadegh Moghanlou, Ali Tarlani Beris
This study provides a detailed analysis of the Spark Plasma Sintering (SPS) process for Zirconium Diboride (ZrB2) ceramics, utilizing the finite element method in COMSOL Multiphysics. The focus is on understanding the temperature distribution during the SPS of a ZrB2 sample in a graphite die. Heat diffusion equations, augmented with Joule heating considerations, are utilized to simulate temperature variations within the system over time. Critical boundary conditions at the system's extremities are modeled as convection cooling. The Analysis of Variance (ANOVA) reveals that the diameter of the sample is the most significant factor influencing the peak temperature at the center of the ZrB2 sample. It is found that the sample diameter's variance accounts for a predominant impact on temperature, markedly more than other factors such as the die's outer diameter and sample thickness. Notably, the standard deviation of the temperature in the axial direction across all samples is less than 4 °C, a value that is statistically minor in comparison to the sintering temperatures, which are around 2000 °C. These findings are instrumental in providing an in-depth understanding of the SPS process, which is essential for the optimization of sintering parameters for ZrB2 ceramics.
{"title":"A simulative approach to obtain higher temperatures during spark plasma sintering of ZrB2 ceramics by geometry optimization","authors":"Milad Sakkaki, Mohsen Naderi, M. Vajdi, Farhad Sadegh Moghanlou, Ali Tarlani Beris","doi":"10.53063/synsint.2023.34178","DOIUrl":"https://doi.org/10.53063/synsint.2023.34178","url":null,"abstract":"This study provides a detailed analysis of the Spark Plasma Sintering (SPS) process for Zirconium Diboride (ZrB2) ceramics, utilizing the finite element method in COMSOL Multiphysics. The focus is on understanding the temperature distribution during the SPS of a ZrB2 sample in a graphite die. Heat diffusion equations, augmented with Joule heating considerations, are utilized to simulate temperature variations within the system over time. Critical boundary conditions at the system's extremities are modeled as convection cooling. The Analysis of Variance (ANOVA) reveals that the diameter of the sample is the most significant factor influencing the peak temperature at the center of the ZrB2 sample. It is found that the sample diameter's variance accounts for a predominant impact on temperature, markedly more than other factors such as the die's outer diameter and sample thickness. Notably, the standard deviation of the temperature in the axial direction across all samples is less than 4 °C, a value that is statistically minor in comparison to the sintering temperatures, which are around 2000 °C. These findings are instrumental in providing an in-depth understanding of the SPS process, which is essential for the optimization of sintering parameters for ZrB2 ceramics.","PeriodicalId":22113,"journal":{"name":"Synthesis and Sintering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138966254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-17DOI: 10.53063/synsint.2023.34190
Leila Karamzadeh, E. Salahi, I. Mobasherpour, Armin Rajabi, Masomeh Javaheri
This paper presents the synthesis of nano hydroxyapatite using deposition process and eggshell as a cost-effective starting material. This study investigates its potential as an effective adsorbent for heavy metals. Various analytical techniques, including X-ray diffraction (XRD), X-ray fluorescence spectroscopy (XRF), Fourier transform infrared (FTIR), surface area measurement (BET), and scanning electron microscopy (SEM), were used to characterize the composition. The main objective was to evaluate the suitability of the synthesized hydroxyapatite as a heavy metal adsorbent in aqueous solutions. The results of this research showed that hydroxyapatite, which has a particle size in the range of nanometers and a specific area of 150 square meters per gram, and has the necessary properties for absorption, was successfully processed. The results showed that the prepared samples had a uniform mesopore distribution between 2 and 3 nm and 6 and 20 nm.
{"title":"Characterization of nano-hydroxyapatite synthesized from eggshells for absorption of heavy metals","authors":"Leila Karamzadeh, E. Salahi, I. Mobasherpour, Armin Rajabi, Masomeh Javaheri","doi":"10.53063/synsint.2023.34190","DOIUrl":"https://doi.org/10.53063/synsint.2023.34190","url":null,"abstract":"This paper presents the synthesis of nano hydroxyapatite using deposition process and eggshell as a cost-effective starting material. This study investigates its potential as an effective adsorbent for heavy metals. Various analytical techniques, including X-ray diffraction (XRD), X-ray fluorescence spectroscopy (XRF), Fourier transform infrared (FTIR), surface area measurement (BET), and scanning electron microscopy (SEM), were used to characterize the composition. The main objective was to evaluate the suitability of the synthesized hydroxyapatite as a heavy metal adsorbent in aqueous solutions. The results of this research showed that hydroxyapatite, which has a particle size in the range of nanometers and a specific area of 150 square meters per gram, and has the necessary properties for absorption, was successfully processed. The results showed that the prepared samples had a uniform mesopore distribution between 2 and 3 nm and 6 and 20 nm.","PeriodicalId":22113,"journal":{"name":"Synthesis and Sintering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138965929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-02DOI: 10.53063/synsint.2023.34183
Niloufar Moharrer Navaei, Narvan Moharrer Navaei
Breast cancer, a global health concern claiming approximately 685,000 lives in 2020, necessitates continual advancements in therapeutic strategies. Estrogen and aromatase play pivotal roles in hormone-responsive breast cancer, with 80% of patients exhibiting estrogen receptor-positive tumors. Aromatase inhibitors (AIs), notably non-steroidal inhibitors like anastrozole and letrozole, have significantly improved outcomes, yet challenges persist, including side effects. This review focuses on recent developments in AIs, exploring xanthone derivatives, imidazole derivatives, and curcumin derivatives as potential inhibitors of aromatase. Molecular docking studies, employing Auto Dock and other tools, reveal the binding affinities and interactions of these compounds with the aromatase enzyme. Among xanthones, Erythrommone emerges as a potent inhibitor, holding promise for clinical trials. Imidazole derivatives, synthesized through the Debus-Radziszewski reaction, demonstrate anticancer potential, with compounds like 1a exhibiting superior efficacy against MCF7 cells. ADME-Tox analyses indicate promising drug-likeness but reveal potential mutagenic effects and environmental impacts. Curcumin derivatives, particularly 1,5-diaryl-1,4-pentadien-3-ones, present alternatives to address curcumin's bioavailability challenges. A study of 25 compounds (DKC) identifies DKC-10 as a potent inhibitor, outperforming established breast cancer drugs in terms of binding affinity and interactions with aromatase and ERα+ receptors. These findings underscore the importance of exploring diverse chemical structures in developing AIs, paving the way for more effective and well-tolerated therapeutics. The integration of computational techniques, such as molecular docking studies, accelerates drug discovery by predicting interactions at the molecular level. Overall, this comprehensive review provides valuable insights into the evolving landscape of aromatase inhibitors, offering a roadmap for future research and the development of advanced breast cancer therapeutics.
{"title":"Unlocking the potential of aromatase inhibitors: recent advances in drug design, synthesis, docking activity, and in vitro bioactivity evaluations","authors":"Niloufar Moharrer Navaei, Narvan Moharrer Navaei","doi":"10.53063/synsint.2023.34183","DOIUrl":"https://doi.org/10.53063/synsint.2023.34183","url":null,"abstract":"Breast cancer, a global health concern claiming approximately 685,000 lives in 2020, necessitates continual advancements in therapeutic strategies. Estrogen and aromatase play pivotal roles in hormone-responsive breast cancer, with 80% of patients exhibiting estrogen receptor-positive tumors. Aromatase inhibitors (AIs), notably non-steroidal inhibitors like anastrozole and letrozole, have significantly improved outcomes, yet challenges persist, including side effects. This review focuses on recent developments in AIs, exploring xanthone derivatives, imidazole derivatives, and curcumin derivatives as potential inhibitors of aromatase. Molecular docking studies, employing Auto Dock and other tools, reveal the binding affinities and interactions of these compounds with the aromatase enzyme. Among xanthones, Erythrommone emerges as a potent inhibitor, holding promise for clinical trials. Imidazole derivatives, synthesized through the Debus-Radziszewski reaction, demonstrate anticancer potential, with compounds like 1a exhibiting superior efficacy against MCF7 cells. ADME-Tox analyses indicate promising drug-likeness but reveal potential mutagenic effects and environmental impacts. Curcumin derivatives, particularly 1,5-diaryl-1,4-pentadien-3-ones, present alternatives to address curcumin's bioavailability challenges. A study of 25 compounds (DKC) identifies DKC-10 as a potent inhibitor, outperforming established breast cancer drugs in terms of binding affinity and interactions with aromatase and ERα+ receptors. These findings underscore the importance of exploring diverse chemical structures in developing AIs, paving the way for more effective and well-tolerated therapeutics. The integration of computational techniques, such as molecular docking studies, accelerates drug discovery by predicting interactions at the molecular level. Overall, this comprehensive review provides valuable insights into the evolving landscape of aromatase inhibitors, offering a roadmap for future research and the development of advanced breast cancer therapeutics.","PeriodicalId":22113,"journal":{"name":"Synthesis and Sintering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138607027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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