Effects of zinc oxide nanoparticles on renal function in mice

A. Noori, F. Karimi
{"title":"Effects of zinc oxide nanoparticles on renal function in mice","authors":"A. Noori, F. Karimi","doi":"10.12692/ijb/5.9.140-146","DOIUrl":null,"url":null,"abstract":"Background: Considering the medical applications of zinc oxide nanoparticles, evaluating their adverse effects on the organisms is important. Materials and Methods: In this study, the effect of a single injection (ip) of zinc oxide nanoparticles (50, 100, 200, 300mg/kg) on changes in the renal parameters (uric acid, creatinin, urea) was studied after 8 and 30 days of the treatment. Results: Results showed that the urea and creatinine levels in the 300 mg/kg group were significantly increased 8 days after the injection (P Conclusion: It seems that a single injection of zinc oxide nanoparticles, especially at high doses (300 mg/kg), has a short-term effect (8 days) on the renal function, but after a month, possibly with the gradual elimination of nanoparticles uptake into the kidney, these effects disappear. However, further studies with more injections are essential.","PeriodicalId":17854,"journal":{"name":"KAUMS Journal","volume":"48 1","pages":"603-604"},"PeriodicalIF":0.0000,"publicationDate":"2013-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"23","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"KAUMS Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.12692/ijb/5.9.140-146","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 23

Abstract

Background: Considering the medical applications of zinc oxide nanoparticles, evaluating their adverse effects on the organisms is important. Materials and Methods: In this study, the effect of a single injection (ip) of zinc oxide nanoparticles (50, 100, 200, 300mg/kg) on changes in the renal parameters (uric acid, creatinin, urea) was studied after 8 and 30 days of the treatment. Results: Results showed that the urea and creatinine levels in the 300 mg/kg group were significantly increased 8 days after the injection (P Conclusion: It seems that a single injection of zinc oxide nanoparticles, especially at high doses (300 mg/kg), has a short-term effect (8 days) on the renal function, but after a month, possibly with the gradual elimination of nanoparticles uptake into the kidney, these effects disappear. However, further studies with more injections are essential.
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
氧化锌纳米颗粒对小鼠肾功能的影响
背景:考虑到氧化锌纳米颗粒的医学应用,评估其对生物体的不良影响是重要的。材料与方法:本研究采用单次注射氧化锌纳米颗粒(50、100、200、300mg/kg)对大鼠肾脏参数(尿酸、肌凝素、尿素)的影响。结果:结果显示,注射后8天,300 mg/kg组的尿素和肌酐水平显著升高(P)。结论:单次注射氧化锌纳米颗粒,特别是高剂量(300 mg/kg),对肾功能有短期影响(8天),但一个月后,可能随着纳米颗粒进入肾脏的逐渐消除,这些影响就消失了。然而,更多注射的进一步研究是必要的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
Effects of zinc oxide nanoparticles on renal function in mice MITOCHONDRIAL MYOPATHY, ENCEPHALOPATHY, LACTIC ACIDOSIS AND STROKE-LIKE EPISODES Non-alcoholic fatty liver disease Effect of Metronidazole on Spermatogenesis, Plasma Gonadotrophins and Testosterone in Male Rats
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1