A Friendly Environment Approach for determination of paracetamol

H. Mahmood
{"title":"A Friendly Environment Approach for determination of paracetamol","authors":"H. Mahmood","doi":"10.33899/edusj.2019.125964.1011","DOIUrl":null,"url":null,"abstract":"This paper involves a determination of paracetamol using less environment harmful reagent; the hydroxy analog of the pharmaceutical naproxen replaces the chemical reagent in which it is used as a coupling agent for the diazotized p-aminophenol (the hydrolysis product of paracetamol).The paper offers a determination of an analgesic paracetamol in the presence of high content of another analgesic . Paracetamol azo-dye formed shows the higher absorption peak at 500 nm. Absorbanceconcentration relation is liner over the range from 10 to 650 μg/20ml, (i.e. 0.5-32.5 ppm) with a good sensitivity (molar absorptivity 1.2x10 l.mol.cm) ; good precision (RSD better than ±0.275%) and high accuracy (relative error less than + 0.77%), Sandell's sensitivity index is 0.0124μg.cm, the calculated limit of detection (LOD) is 0.0030 μg/ml and the evaluated limit of quantitation (LOQ) is 0.0101 μg/ml. The application of the method exhibits a successful results for determination of paracetamol in dosage forms and it's already applied for the determination of paracetamol in presence of naproxen .","PeriodicalId":15610,"journal":{"name":"Journal of Education Science","volume":"52 1","pages":"230-240"},"PeriodicalIF":0.0000,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Education Science","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.33899/edusj.2019.125964.1011","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 3

Abstract

This paper involves a determination of paracetamol using less environment harmful reagent; the hydroxy analog of the pharmaceutical naproxen replaces the chemical reagent in which it is used as a coupling agent for the diazotized p-aminophenol (the hydrolysis product of paracetamol).The paper offers a determination of an analgesic paracetamol in the presence of high content of another analgesic . Paracetamol azo-dye formed shows the higher absorption peak at 500 nm. Absorbanceconcentration relation is liner over the range from 10 to 650 μg/20ml, (i.e. 0.5-32.5 ppm) with a good sensitivity (molar absorptivity 1.2x10 l.mol.cm) ; good precision (RSD better than ±0.275%) and high accuracy (relative error less than + 0.77%), Sandell's sensitivity index is 0.0124μg.cm, the calculated limit of detection (LOD) is 0.0030 μg/ml and the evaluated limit of quantitation (LOQ) is 0.0101 μg/ml. The application of the method exhibits a successful results for determination of paracetamol in dosage forms and it's already applied for the determination of paracetamol in presence of naproxen .
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
环境友好法测定对乙酰氨基酚
采用对环境危害较小的试剂测定对乙酰氨基酚;药物萘普生的羟基类似物取代了作为重氮化对氨基酚(扑热息痛的水解产物)偶联剂的化学试剂。本文提供了一种在另一种镇痛药的高含量存在下对乙酰氨基酚的测定方法。对乙酰氨基酚偶氮染料在500 nm处有较高的吸收峰。在10 ~ 650 μg/20ml(即0.5 ~ 32.5 ppm)范围内,吸光度与浓度呈线性关系,具有良好的灵敏度(摩尔吸光度为1.2 × 10 l.mol.cm);精密度好(RSD优于±0.275%),准确度高(相对误差小于+ 0.77%),Sandell的灵敏度指数为0.0124μg。计算检出限(LOD)为0.0030 μg/ml,定量评价限(LOQ)为0.0101 μg/ml。应用该方法可成功测定各剂型对乙酰氨基酚的含量,并已应用于萘普生存在下对乙酰氨基酚的含量测定。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
PENGEMBANGAN KEMAMPUAN VOCABULARY BAHASA INGGRIS MELALUI METODE AUDIO LISTENING PADA SISWA KELAS 1 SMPN JAYA ACEH JAYA KESIAPSIAGAAN KOMUNITAS SEKOLAH DALAM MENGHADAPI BENCANA GEMPA BUMI DAN TSUNAMI DI SMA NEGERI 1 BAITUSSALAM KABUPATEN ACEH BESAR IDENTIFIKASI KARAKTER MORFOLOGI DAN MANFAAT BUNGA KERTAS (Bougainvillea) DI DESA SENEREN, KECAMATAN PANTAN CUACA KABUPATEN GAYO LUES, ACEH PENINGKATAN KEMAMPUAN MENGANALISIS UNSUR INTRINSIK CERPEN MELALUI PEMBELAJARAN INKUIRI PADA SISWA KELAS XI MIA-2 PENERAPAN MODEL KOOPERATIF TIPE SNOWBALL THROWING UNTUK MENINGKATKAN PEMAHAMAN SISWA PADA MATERI TIRANI MATAHARI TERBIT
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1