RNase: A Novel Enzyme For Treatment Of Cancers

S. Suri, B. Panda, S. Javed, A. Mohd
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引用次数: 6

Abstract

Ribonucleases (RNase) catalyses the breakdown of RNA into smaller components. The cytotoxic effects of RNase include the RNA cleavage leading to the inhibition of the protein synthesis and the induction of apoptosis. RNases uniquely influence several functions in the tumor cell simultaneously and demonstrated the ability to overcome multi-drug resistance and to enhance the cytotoxicity of a variety of anti-cancer agents. Different RNases such as onconases, bovine seminal RNase, RNase T1, α-sarcin, RNase P, actibind and RNaseT2 have recently been studied for the treatment of different type of cancers.
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核糖核酸酶:一种治疗癌症的新酶
核糖核酸酶(RNase)催化RNA分解成更小的组分。RNase的细胞毒性作用包括RNA裂解,抑制蛋白质合成和诱导细胞凋亡。核糖核酸酶独特地同时影响肿瘤细胞中的几种功能,并证明了克服多种药物耐药性和增强多种抗癌药物的细胞毒性的能力。不同的RNase,如onconases、牛精液RNase、RNase T1、α-sarcin、RNase P、actibind和RNaseT2,最近被研究用于治疗不同类型的癌症。
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