Anemia in early life (up to the age of 6 months) – Is it really a disease burden? A cross-sectional study from Sub-Himalayan region

Charu Maggo, Shivani Gahalot, Seema Sharma
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Abstract

Objectives: To determine whether or not, all breastfed newborns should get preventive iron (up to age of 6 months). It will determine the disease burden and clinicopathological profile of anemia in infants up to 6 months and its correlation with maternal Hb levels. Materials and Methods: A 4-month hospital-based cross-sectional study was conducted in all infants under the age of 6 months and their mothers admitted to the pediatric ward of a tertiary health care center in the Sub-Himalayan region. Results: About 42% of infants (up to 6 months of age) and 64% of mothers were found to be anemic. It was found that mothers of 74% of total anemic infants were also anemic. Furthermore, in 79% cases mothers with good ferritin stores (?12 ng/ml) also have infants with good ferritin levels (?10 ng/ml). It was found that mothers who have not consumed adequate amount of iron in their pregnancy, 44% of them have anemic infants. Despite the fact that the association between newborn and maternal characteristics is not statistically significant, the results are noteworthy, indicating the need for a more comprehensive investigation to determine the relationship. Conclusion: High rates of anemia in early life point to the need of multicentric as well as population-based study so that we can collect evidence to start iron prophylaxis in this highly vulnerable developing age group of 0–6 months. Further higher rates of anemia in mothers warrant the strengthening in the implementation plan of iron and folic acid supplementation to all females of reproductive age group.
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生命早期(6个月前)贫血——这真的是一种疾病负担吗?喜马拉雅地区的横断面研究
目的:确定是否所有母乳喂养的新生儿都应该服用预防性铁(6个月以下)。它将确定6个月以下婴儿贫血的疾病负担和临床病理特征及其与母亲Hb水平的相关性。材料和方法:对喜马拉雅地区一家三级卫生保健中心儿科病房收治的所有6个月以下婴儿及其母亲进行了为期4个月的以医院为基础的横断面研究。结果:约42%的婴儿(6个月以下)和64%的母亲被发现贫血。研究发现,在所有贫血婴儿中,有74%的母亲也患有贫血。此外,在79%的情况下,铁蛋白储存良好的母亲(?12 ng/ml)的婴儿也有良好的铁蛋白水平(?10 ng / ml)。研究发现,怀孕期间没有摄入足量铁的母亲,有44%的婴儿患有贫血。尽管新生儿和母亲特征之间的关联在统计上并不显著,但结果值得注意,表明需要更全面的调查来确定这种关系。结论:生命早期贫血的高发生率表明需要多中心和基于人群的研究,以便我们可以收集证据,在0-6个月这一高度脆弱的发育年龄组开始铁预防。由于母亲贫血率进一步升高,有必要加强向所有育龄妇女补充铁和叶酸的执行计划。
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