Pub Date : 2023-09-06DOI: 10.32677/ijch.v10i8.4202
Rashmi Agrawal, Amit Agrawal, J. Mandumpala
In children, urinary tract infection (UTI) is a common condition. Prompt identification and treatment are critical for reducing morbidity associated with this illness. Throughout infancy, the symptoms and indications remain nonspecific. During the first 2 years of life, the most prevalent sign of UTI is unexplained fever. Symptoms and indicators of pyelonephritis after the 2nd year of life include fever, chills, rigor, flank discomfort, and costovertebral angle tenderness. Suprapubic pain, dysuria, urinary frequency, urgency, murky urine, malodourous urine, and suprapubic tenderness are examples of the lower tract symptoms and indicators. When UTI is suspected, a urinalysis and urine culture should be conducted. In the treatment of acute uncomplicated UTI, second or third-generation cephalosporin and amoxicillin-clavulanate are currently the medications of choice. Parenteral antibiotic therapy is advised for infants under 2 months of age and any child who seems toxic is hemodynamically unstable, is immunocompromised, is unable to tolerate, or is not responding to oral medication. This study focuses on the most recent updates about UTIs in children and provides a comprehensive overview of the subject.
{"title":"Urinary tract infection in pediatric patients – Recent updates","authors":"Rashmi Agrawal, Amit Agrawal, J. Mandumpala","doi":"10.32677/ijch.v10i8.4202","DOIUrl":"https://doi.org/10.32677/ijch.v10i8.4202","url":null,"abstract":"In children, urinary tract infection (UTI) is a common condition. Prompt identification and treatment are critical for reducing morbidity associated with this illness. Throughout infancy, the symptoms and indications remain nonspecific. During the first 2 years of life, the most prevalent sign of UTI is unexplained fever. Symptoms and indicators of pyelonephritis after the 2nd year of life include fever, chills, rigor, flank discomfort, and costovertebral angle tenderness. Suprapubic pain, dysuria, urinary frequency, urgency, murky urine, malodourous urine, and suprapubic tenderness are examples of the lower tract symptoms and indicators. When UTI is suspected, a urinalysis and urine culture should be conducted. In the treatment of acute uncomplicated UTI, second or third-generation cephalosporin and amoxicillin-clavulanate are currently the medications of choice. Parenteral antibiotic therapy is advised for infants under 2 months of age and any child who seems toxic is hemodynamically unstable, is immunocompromised, is unable to tolerate, or is not responding to oral medication. This study focuses on the most recent updates about UTIs in children and provides a comprehensive overview of the subject.","PeriodicalId":22476,"journal":{"name":"The Indian journal of child health","volume":"88 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84184875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-06DOI: 10.32677/ijch.v10i8.4185
Mythili R Iyer, V. S. Nanduri
Autism spectrum disorder (ASD) is a complex formative condition, described by tenacious difficulties in social cooperation and correspondence and confined and dreary behavior. There is no solution for Autism and a few treatments are accessible as well as certain drugs to further develop life for impacted youngsters and grown-ups. This paper presents a case of a boy who was treated from the age of 8 years with Yoga Prana Vidya (YPV) healing complementarily to other therapies achieving positive progress. This study uses the case study method by going through the patient’s medical records, the healer’s records, and the patient’s mother’s feedback. YPV healing was applied as a long-term intervention spanning 3 years, complementary to home-based “Son-Rise” program therapy. Within the first 15 days of YPV healing, the boy’s improvements were noticeable, and progress began after a stagnant condition over the previous 2 years. After 3 months of YPV intervention, the boy became more receptive to faster learning. After a year of healing, the boy’s condition improved from Grade 1 to Grade 2 of the “Son-Rise” gradation. At the end of the 3rd year, the boy achieved most of the Grade 3. YPV healing is being continued further. The integrated and holistic system of YPV healing therapy was successfully applied to the autism case as a complementary therapy, achieving the patient’s faster progress, and enabling parents to overcome social stigma. Further research is recommended on the application of YPV healing therapy in the treatment of ASD.
{"title":"Pediatric autism spectrum disorder: Role of yoga prana vidya system as complementary medicine in accelerating patient progress","authors":"Mythili R Iyer, V. S. Nanduri","doi":"10.32677/ijch.v10i8.4185","DOIUrl":"https://doi.org/10.32677/ijch.v10i8.4185","url":null,"abstract":"Autism spectrum disorder (ASD) is a complex formative condition, described by tenacious difficulties in social cooperation and correspondence and confined and dreary behavior. There is no solution for Autism and a few treatments are accessible as well as certain drugs to further develop life for impacted youngsters and grown-ups. This paper presents a case of a boy who was treated from the age of 8 years with Yoga Prana Vidya (YPV) healing complementarily to other therapies achieving positive progress. This study uses the case study method by going through the patient’s medical records, the healer’s records, and the patient’s mother’s feedback. YPV healing was applied as a long-term intervention spanning 3 years, complementary to home-based “Son-Rise” program therapy. Within the first 15 days of YPV healing, the boy’s improvements were noticeable, and progress began after a stagnant condition over the previous 2 years. After 3 months of YPV intervention, the boy became more receptive to faster learning. After a year of healing, the boy’s condition improved from Grade 1 to Grade 2 of the “Son-Rise” gradation. At the end of the 3rd year, the boy achieved most of the Grade 3. YPV healing is being continued further. The integrated and holistic system of YPV healing therapy was successfully applied to the autism case as a complementary therapy, achieving the patient’s faster progress, and enabling parents to overcome social stigma. Further research is recommended on the application of YPV healing therapy in the treatment of ASD.","PeriodicalId":22476,"journal":{"name":"The Indian journal of child health","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84378416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-06DOI: 10.32677/ijch.v10i8.4062
Aradhana Kankane, Vipin Kumar, Nupur Pandey, Om Shankar Chaurasia
Background: Pancytopenia is defined by a decrease in all three blood components, that is, leukopenia, thrombocytopenia, and anemia below the normal range. This study is an attempt to fill the lacunae regarding the information about pancytopenia in pediatric patients in the Bundelkhand region. The study aimed to study the clinical and etiopathological profile of pancytopenia in children (1–18 years) in the tertiary care center of the Bundelkhand region in central India. Materials and Methods: The present study was a hospital-based cross-sectional observational study conducted to learn about the clinical features, demographic and etiopathological profile of pancytopenia in children. The study was performed with 65 patients aged 1–18 years from September 2021 to August 2022 admitted to the Department of Paediatrics, Maharani Laxmi Bai Medical College and Hospital, Jhansi, and fulfilling inclusion criteria. IBM’s Statistical Package for the Social Sciences version 23 was used for the statistical study. Results: Out of 65 patients, a maximum number of cases were in the age group of 1–6 years (55%). Our study revealed male predominance over females with male-to-female ratio of 2.09:1, mostly belonging to rural areas. The most common presenting complaint was easy fatigue in (90%) of patients followed by fever (54%). The most common physical finding was pallor (100%), followed by splenomegaly and pedal edema (38%) and (18%), respectively. Bone marrow cellularity shows hypocellular marrow (62%), hypercellular (31%), and normocellular (7%). Peripheral smears of most of the patients showed normocytic normochromic (34%), followed by macrocytic hypochromic (30%). Regarding etiology megaloblastic anemia (30%) was reported as the most common cause of pancytopenia followed by malignancies (30%) including myelodysplastic syndrome (9%), multiple myeloma (3%), acute lymphocytic leukemia (9%), and acute myeloid leukemia (9%) followed by aplastic anemia (14%) and sepsis (8%). The study also shows other rare causes of pancytopenia such as disseminated tuberculosis (6%), malaria (9%), and dengue (3%). Conclusion: In the present study, the most common etiologies of pancytopenia come out as nutritional causes, that is, megaloblastic anemia followed by malignancies then aplastic anemia.
背景:全血细胞减少症的定义是三种血液成分均减少，即白细胞减少、血小板减少和贫血低于正常范围。本研究试图填补关于本德尔坎德地区儿童全血细胞减少症信息的空白。该研究旨在研究全血细胞减少症儿童(1-18岁)在印度中部邦德尔坎德地区三级保健中心的临床和病因病理学特征。材料与方法:本研究是一项以医院为基础的横断面观察性研究，旨在了解儿童全血细胞减少症的临床特征、人口学特征和病因病理学特征。该研究纳入了2021年9月至2022年8月在Jhansi Maharani Laxmi Bai医学院和医院儿科住院并符合纳入标准的65名年龄在1-18岁的患者。统计研究使用了IBM的Statistical Package for the Social Sciences version 23。结果:65例患者中，1-6岁年龄组最多(55%)。我们的研究显示男性优势于女性，男女比例为2.09:1，主要集中在农村地区。最常见的主诉是易疲劳(90%)，其次是发热(54%)。最常见的生理表现是苍白(100%)，其次是脾肿大和足部水肿(38%)和(18%)。骨髓细胞结构表现为低细胞骨髓(62%)、高细胞骨髓(31%)和正常细胞骨髓(7%)。大多数患者外周血涂片表现为正红细胞正色(34%)，其次是大细胞低色(30%)。关于病因，巨幼细胞性贫血(30%)是全血细胞减少症最常见的原因，其次是恶性肿瘤(30%)，包括骨髓增生异常综合征(9%)、多发性骨髓瘤(3%)、急性淋巴细胞白血病(9%)和急性髓性白血病(9%)，其次是再生障碍性贫血(14%)和败血症(8%)。该研究还显示了全血细胞减少症的其他罕见病因，如播散性肺结核(6%)、疟疾(9%)和登革热(3%)。结论:在本研究中，全血细胞减少症最常见的病因是营养原因，即巨幼细胞性贫血，其次是恶性肿瘤，然后是再生障碍性贫血。
{"title":"Clinical and etiopathological profile of pancytopenia in children (1-18 years): A study from tertiary care center of Bundelkhand region, central India","authors":"Aradhana Kankane, Vipin Kumar, Nupur Pandey, Om Shankar Chaurasia","doi":"10.32677/ijch.v10i8.4062","DOIUrl":"https://doi.org/10.32677/ijch.v10i8.4062","url":null,"abstract":"Background: Pancytopenia is defined by a decrease in all three blood components, that is, leukopenia, thrombocytopenia, and anemia below the normal range. This study is an attempt to fill the lacunae regarding the information about pancytopenia in pediatric patients in the Bundelkhand region. The study aimed to study the clinical and etiopathological profile of pancytopenia in children (1–18 years) in the tertiary care center of the Bundelkhand region in central India. Materials and Methods: The present study was a hospital-based cross-sectional observational study conducted to learn about the clinical features, demographic and etiopathological profile of pancytopenia in children. The study was performed with 65 patients aged 1–18 years from September 2021 to August 2022 admitted to the Department of Paediatrics, Maharani Laxmi Bai Medical College and Hospital, Jhansi, and fulfilling inclusion criteria. IBM’s Statistical Package for the Social Sciences version 23 was used for the statistical study. Results: Out of 65 patients, a maximum number of cases were in the age group of 1–6 years (55%). Our study revealed male predominance over females with male-to-female ratio of 2.09:1, mostly belonging to rural areas. The most common presenting complaint was easy fatigue in (90%) of patients followed by fever (54%). The most common physical finding was pallor (100%), followed by splenomegaly and pedal edema (38%) and (18%), respectively. Bone marrow cellularity shows hypocellular marrow (62%), hypercellular (31%), and normocellular (7%). Peripheral smears of most of the patients showed normocytic normochromic (34%), followed by macrocytic hypochromic (30%). Regarding etiology megaloblastic anemia (30%) was reported as the most common cause of pancytopenia followed by malignancies (30%) including myelodysplastic syndrome (9%), multiple myeloma (3%), acute lymphocytic leukemia (9%), and acute myeloid leukemia (9%) followed by aplastic anemia (14%) and sepsis (8%). The study also shows other rare causes of pancytopenia such as disseminated tuberculosis (6%), malaria (9%), and dengue (3%). Conclusion: In the present study, the most common etiologies of pancytopenia come out as nutritional causes, that is, megaloblastic anemia followed by malignancies then aplastic anemia.","PeriodicalId":22476,"journal":{"name":"The Indian journal of child health","volume":"53 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72854504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-06DOI: 10.32677/ijch.v10i7.4037
M T P Mohammed, S. Khalid
Background: We encountered infants in our outpatient department (OPD) who have been breastfeeding normally till 3–6 months of age and stopped feeding while awake without any obvious reason, and continued feeding during sleep. This causes much anxiety and concern to the mother and demands intervention. Objectives: The aim of the study was to compare the weight gain of infants who breastfeed only during sleep, with babies who feed normally. Materials and Methods: An observational study has been carried out in pediatric OPD, at Government Medical College Kannur. Totally 30 breastfeeding mothers were interviewed and data were entered in a proforma. Weight gain was taken from the growth chart beginning from birth to 6 months. Results: Among the 30 breastfeeding mothers interviewed, 12 of them had infants who started feeding only during sleep from around 3 to 4 months of age. On the assessment of growth and development among these infants, it was noted that they were comparable with the infants on exclusive breastfeeding without the problem. No failure to thrive or delayed development was noted in the study group as compared to normal. Conclusion: Growth and development was normally attained in infants who breastfeed only while sleeping. As this matter hasn’t been studied anywhere so far and is a cause for anxiety in mothers, it demands further research and study.
{"title":"An observational study to evaluate weight gain of exclusively breastfed infants who feed only while sleeping","authors":"M T P Mohammed, S. Khalid","doi":"10.32677/ijch.v10i7.4037","DOIUrl":"https://doi.org/10.32677/ijch.v10i7.4037","url":null,"abstract":"Background: We encountered infants in our outpatient department (OPD) who have been breastfeeding normally till 3–6 months of age and stopped feeding while awake without any obvious reason, and continued feeding during sleep. This causes much anxiety and concern to the mother and demands intervention. Objectives: The aim of the study was to compare the weight gain of infants who breastfeed only during sleep, with babies who feed normally. Materials and Methods: An observational study has been carried out in pediatric OPD, at Government Medical College Kannur. Totally 30 breastfeeding mothers were interviewed and data were entered in a proforma. Weight gain was taken from the growth chart beginning from birth to 6 months. Results: Among the 30 breastfeeding mothers interviewed, 12 of them had infants who started feeding only during sleep from around 3 to 4 months of age. On the assessment of growth and development among these infants, it was noted that they were comparable with the infants on exclusive breastfeeding without the problem. No failure to thrive or delayed development was noted in the study group as compared to normal. Conclusion: Growth and development was normally attained in infants who breastfeed only while sleeping. As this matter hasn’t been studied anywhere so far and is a cause for anxiety in mothers, it demands further research and study.","PeriodicalId":22476,"journal":{"name":"The Indian journal of child health","volume":"57 2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85434123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-06DOI: 10.32677/ijch.v10i7.4046
M V B Pratyush, Rakesh Kotha, Alimelu Madireddy
{"title":"Fibular hemimelia in a neonate","authors":"M V B Pratyush, Rakesh Kotha, Alimelu Madireddy","doi":"10.32677/ijch.v10i7.4046","DOIUrl":"https://doi.org/10.32677/ijch.v10i7.4046","url":null,"abstract":"","PeriodicalId":22476,"journal":{"name":"The Indian journal of child health","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86531994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-04DOI: 10.32677/ijch.v10i7.3956
Nidha Fatima, Faraaz Adil, Habib G Pathan
Kocher Debre Semealaigne Syndrome (KDSS) is a rare condition with the manifestation of hypothyroidism associated with pseudomuscular hypertrophy. This syndrome is rare in countries with screening programs for hypothyroidism at birth. We are reporting a rare case of KDSS in which earlier diagnosis and treatment would result in the reversal of many symptoms. The main objective of presenting this case is to enlighten pediatricians about prompt diagnosis and timely management to prevent avoidable complications.
{"title":"A case report of Kocher Debre Semelaigne syndrome – Congenital hypothyroidism with pseudomuscular hypertrophy","authors":"Nidha Fatima, Faraaz Adil, Habib G Pathan","doi":"10.32677/ijch.v10i7.3956","DOIUrl":"https://doi.org/10.32677/ijch.v10i7.3956","url":null,"abstract":"Kocher Debre Semealaigne Syndrome (KDSS) is a rare condition with the manifestation of hypothyroidism associated with pseudomuscular hypertrophy. This syndrome is rare in countries with screening programs for hypothyroidism at birth. We are reporting a rare case of KDSS in which earlier diagnosis and treatment would result in the reversal of many symptoms. The main objective of presenting this case is to enlighten pediatricians about prompt diagnosis and timely management to prevent avoidable complications.","PeriodicalId":22476,"journal":{"name":"The Indian journal of child health","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75253162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-01DOI: 10.32677/ijch.v10i7.4066
Pulkit Johar, Oshin Puri, Prashant Kumar Verma
There is a high prevalence of genetic disorders in India. Factors that favor high prevalence are the large population, high birth rate, and consanguineous marriage in many communities. The majority of physicians rely upon knowledge of medical schools gained at the undergraduate level. Currently, at the undergraduate level Medical Genetics, is being taught by different departments in different semesters. It creates a lack of continuity and integrity. This Study identified that medical students have limited knowledge about basic medical genetics, moderate awareness regarding the epidemiological and social impact of genetic diseases and an optimistic attitude towards management of genetic diseases in the society. Curricular teaching and practical exposure might be helpful in increasing the knowledge and awareness and inculcate practicality in students’ attitude.
{"title":"Assessment of knowledge, awareness, and attitude toward genetic diseases among medical students studying in a tertiary health-care teaching hospital in Uttarakhand, India","authors":"Pulkit Johar, Oshin Puri, Prashant Kumar Verma","doi":"10.32677/ijch.v10i7.4066","DOIUrl":"https://doi.org/10.32677/ijch.v10i7.4066","url":null,"abstract":"There is a high prevalence of genetic disorders in India. Factors that favor high prevalence are the large population, high birth rate, and consanguineous marriage in many communities. The majority of physicians rely upon knowledge of medical schools gained at the undergraduate level. Currently, at the undergraduate level Medical Genetics, is being taught by different departments in different semesters. It creates a lack of continuity and integrity. This Study identified that medical students have limited knowledge about basic medical genetics, moderate awareness regarding the epidemiological and social impact of genetic diseases and an optimistic attitude towards management of genetic diseases in the society. Curricular teaching and practical exposure might be helpful in increasing the knowledge and awareness and inculcate practicality in students’ attitude. ","PeriodicalId":22476,"journal":{"name":"The Indian journal of child health","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85351211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-01DOI: 10.32677/ijch.v10i7.4055
Milind Kanjalkar, Prachi Jethwa, Atul Adaniya
Caffey’s disease is a bone disorder that most often occurs in babies. It is inherited in an autosomal dominant pattern but not all people who inherit the genetic change develop signs and symptoms. Most people with Caffey’s disease have no further problems related to the disorder after early childhood. Occasionally, another episode of hyperostosis occurs years later. The peculiarity about this case was its presence in the adolescent stage of the child’s growth. This condition is mostly underreported due to its regression in childhood itself, and hence we have reported this unique case. The parents presented with complaints of a different etiology and with complaints of bone pains and deformity since birth. He was diagnosed primarily with Caffey’s disease after ruling out other diagnoses. There is very little literature on Caffey’s disease due to its regression in early childhood.
{"title":"Case report on Caffeys disease in an adolescent with a familial aspect","authors":"Milind Kanjalkar, Prachi Jethwa, Atul Adaniya","doi":"10.32677/ijch.v10i7.4055","DOIUrl":"https://doi.org/10.32677/ijch.v10i7.4055","url":null,"abstract":"Caffey’s disease is a bone disorder that most often occurs in babies. It is inherited in an autosomal dominant pattern but not all people who inherit the genetic change develop signs and symptoms. Most people with Caffey’s disease have no further problems related to the disorder after early childhood. Occasionally, another episode of hyperostosis occurs years later. The peculiarity about this case was its presence in the adolescent stage of the child’s growth. This condition is mostly underreported due to its regression in childhood itself, and hence we have reported this unique case. The parents presented with complaints of a different etiology and with complaints of bone pains and deformity since birth. He was diagnosed primarily with Caffey’s disease after ruling out other diagnoses. There is very little literature on Caffey’s disease due to its regression in early childhood.","PeriodicalId":22476,"journal":{"name":"The Indian journal of child health","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80089894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-06DOI: 10.32677/ijch.v10i6.3992
Sreelakshmi S Kumar, Bindu A, Purushothaman K K
Congenital leukemia (CL) refers to leukemia diagnosed at birth or within the 1st month of life. Incidence is reported to be 1 in 5 million. We report the case of a 22-day-old neonate, who presented to us with features of sepsis, with predominant blasts in the peripheral smear, and was subsequently detected to have CL. Although the etiology is unknown, the presence of leukemia at birth suggests possible intrauterine exposure to drugs or other toxins or the presence of genetic abnormalities. The course of CL is one of the rapid deterioration and death from hemorrhage and infection unless treated appropriately, with adequate chemo and radiotherapy. These neonates pose a huge challenge to treat due to their high mortality, owing to both the high risk of treatment-related mortality and disease relapse. Early diagnosis and prompt initiation of treatment are essential for a better prognosis.
{"title":"A case report of congenital leukemia – AML M0","authors":"Sreelakshmi S Kumar, Bindu A, Purushothaman K K","doi":"10.32677/ijch.v10i6.3992","DOIUrl":"https://doi.org/10.32677/ijch.v10i6.3992","url":null,"abstract":"Congenital leukemia (CL) refers to leukemia diagnosed at birth or within the 1st month of life. Incidence is reported to be 1 in 5 million. We report the case of a 22-day-old neonate, who presented to us with features of sepsis, with predominant blasts in the peripheral smear, and was subsequently detected to have CL. Although the etiology is unknown, the presence of leukemia at birth suggests possible intrauterine exposure to drugs or other toxins or the presence of genetic abnormalities. The course of CL is one of the rapid deterioration and death from hemorrhage and infection unless treated appropriately, with adequate chemo and radiotherapy. These neonates pose a huge challenge to treat due to their high mortality, owing to both the high risk of treatment-related mortality and disease relapse. Early diagnosis and prompt initiation of treatment are essential for a better prognosis.","PeriodicalId":22476,"journal":{"name":"The Indian journal of child health","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78195213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-06DOI: 10.32677/ijch.v10i6.4040
Jayashree Rao, N. K.
Background: Thalassemia is one of the common inherited blood disorders and Beta Thalassemia Major is a homozygous form of deficiency of beta globin chain synthesis causing severe transfusion-dependent anemia, manifesting between 6 and 24 months of life. Objectives: The objective of the study is to study the pattern of cardiac function in children and adolescents with beta-thalassemia major by 2D Echocardiography and its correlation with serum ferritin levels. Methods: Fifty subjects diagnosed with Beta Thalassemia Major, after applying the inclusion and exclusion criteria were included in Group 1, and 50 age and gender-matched subjects without Beta Thalassemia Major were included in Group 2. Serum ferritin level was measured using Cobas 6000 analyzer. Echocardiography was done with the following parameters: Posterior wall thickness-diastolic (PWT-D), posterior wall thickness- systolic (PWT-S), left ventricular internal diameter-diastole (LVID-D), left ventricular internal diameter-systole (LVID-S), septal thickness and tricuspid regurgitation (TR) velocity. Results: Among the 50 study population, 28 children belonged to the age group 5–10 years (56%) and 22 children belonged to the age group 10–15 years (44%). Among the cardiac parameters, The PWT-D, PWT-S, LVID-D, LVID-S, TR velocity, and septal thickness values were higher in the cases group compared to the control group with p values suggesting strong significance. The ejection fraction in the cases was lower than the control group with a strongly significant p-value. Conclusion: Children with thalassemia have impaired cardiac function and the degree of dysfunction is correlated to the serum ferritin levels. Regular transfusion and adequate chelation are essential to decrease morbidity and mortality.
{"title":"A study conducted in a tertiary care hospital to assess the cardiac function in paediatric beta thalassemia major patients and correlation with serum ferritin levels which are indicative of chelation status of the patients","authors":"Jayashree Rao, N. K.","doi":"10.32677/ijch.v10i6.4040","DOIUrl":"https://doi.org/10.32677/ijch.v10i6.4040","url":null,"abstract":"Background: Thalassemia is one of the common inherited blood disorders and Beta Thalassemia Major is a homozygous form of deficiency of beta globin chain synthesis causing severe transfusion-dependent anemia, manifesting between 6 and 24 months of life. Objectives: The objective of the study is to study the pattern of cardiac function in children and adolescents with beta-thalassemia major by 2D Echocardiography and its correlation with serum ferritin levels. Methods: Fifty subjects diagnosed with Beta Thalassemia Major, after applying the inclusion and exclusion criteria were included in Group 1, and 50 age and gender-matched subjects without Beta Thalassemia Major were included in Group 2. Serum ferritin level was measured using Cobas 6000 analyzer. Echocardiography was done with the following parameters: Posterior wall thickness-diastolic (PWT-D), posterior wall thickness- systolic (PWT-S), left ventricular internal diameter-diastole (LVID-D), left ventricular internal diameter-systole (LVID-S), septal thickness and tricuspid regurgitation (TR) velocity. Results: Among the 50 study population, 28 children belonged to the age group 5–10 years (56%) and 22 children belonged to the age group 10–15 years (44%). Among the cardiac parameters, The PWT-D, PWT-S, LVID-D, LVID-S, TR velocity, and septal thickness values were higher in the cases group compared to the control group with p values suggesting strong significance. The ejection fraction in the cases was lower than the control group with a strongly significant p-value. Conclusion: Children with thalassemia have impaired cardiac function and the degree of dysfunction is correlated to the serum ferritin levels. Regular transfusion and adequate chelation are essential to decrease morbidity and mortality.","PeriodicalId":22476,"journal":{"name":"The Indian journal of child health","volume":"240 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76917010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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