A. Kuzikov, A. Veselovsky, I. Toropygin, A. Archakov, V. Shumyantseva
{"title":"INTERACTIONS OF ANTICANCER DRUGS – ABIRATERONE AND GALETERONE – WITH CYTOCHROME P450 51A1 (CYP51A1)","authors":"A. Kuzikov, A. Veselovsky, I. Toropygin, A. Archakov, V. Shumyantseva","doi":"10.37747/2312-640x-2021-19-149-150","DOIUrl":null,"url":null,"abstract":"Interactions of abiraterone and galeterone with steroid-metabolizing cytochrome P450 (CYP51A1) was studied. Binding of substrate type was observed, which indicates possible metabolism of abiraterone and galeterone by CYP51A1, however electrocatalytic reaction only towards abiraterone was observed.","PeriodicalId":13077,"journal":{"name":"http://eng.biomos.ru/conference/articles.htm","volume":"107 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"http://eng.biomos.ru/conference/articles.htm","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.37747/2312-640x-2021-19-149-150","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Interactions of abiraterone and galeterone with steroid-metabolizing cytochrome P450 (CYP51A1) was studied. Binding of substrate type was observed, which indicates possible metabolism of abiraterone and galeterone by CYP51A1, however electrocatalytic reaction only towards abiraterone was observed.