{"title":"HMGB1/RAGE signal and respiratory diseases and its research progress","authors":"Jingyi Sun, Yabing Sun","doi":"10.3760/CMA.J.ISSN.1673-436X.2020.03.014","DOIUrl":null,"url":null,"abstract":"High mobility group box-1 protein (HMGB1) is widely involved in various inflammatory response processes in the body.The receptor for advanced glycation end-products (RAGE) and some Toll-like receptors are its main receptors.A large number of studies have confirmed that HMGB1 can induce various physiological and pathological effects of inflammatory response, immune response, tumor occurrence through the RAGE receptor pathway, and participate in the occurrence and development of various diseases.HMGB1 is widely expressed in lung tissues, and HMGB1/RAGE signal has been shown to be involved in the pathogenesis of many chronic airway diseases.Especially in the occurrence and development of asthma, HMGB1/RAGE signal has been confirmed to play an important role in it, but the specific mechanism is still unclear.This article preliminarily explains the role of HMGB1/RAGE in respiratory diseases, especially asthma, and related research progress. \n \n \nKey words: \nHMGB1/RAGE signal; Respiratory diseases; Asthma","PeriodicalId":10004,"journal":{"name":"Chinese Journal of Asthma","volume":"198 1","pages":"229-234"},"PeriodicalIF":0.0000,"publicationDate":"2020-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chinese Journal of Asthma","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3760/CMA.J.ISSN.1673-436X.2020.03.014","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
High mobility group box-1 protein (HMGB1) is widely involved in various inflammatory response processes in the body.The receptor for advanced glycation end-products (RAGE) and some Toll-like receptors are its main receptors.A large number of studies have confirmed that HMGB1 can induce various physiological and pathological effects of inflammatory response, immune response, tumor occurrence through the RAGE receptor pathway, and participate in the occurrence and development of various diseases.HMGB1 is widely expressed in lung tissues, and HMGB1/RAGE signal has been shown to be involved in the pathogenesis of many chronic airway diseases.Especially in the occurrence and development of asthma, HMGB1/RAGE signal has been confirmed to play an important role in it, but the specific mechanism is still unclear.This article preliminarily explains the role of HMGB1/RAGE in respiratory diseases, especially asthma, and related research progress.
Key words:
HMGB1/RAGE signal; Respiratory diseases; Asthma
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