Efficacy of the use of chondroitin sulphate and glucosamine for the treatment of temporomandibular joint dysfunction: A systematic review and meta-analysis.
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引用次数: 0
Abstract
Objective: To evaluate the efficacy of chondroitin sulfate (CS) and glucosamine (GS), the most relevant drugs of "Symptomatic Slow Acting Drug for Osteoarthritis" (SYSADOA), in the functional and symptomatic improvement of temporomandibular dysfunction. Although, controversy exists regarding their benefit.
Methods: An electronic search was conducted to retrieve randomized controlled clinical trials (RCTs). The risk of bias assessment was evaluated using the Cochrane Collaboration's tool. Data were meta-analyzed with a random effect model whenever possible.
Results: Three RCTs were included. Qualitative results showed a decrease in pain, joint noise, and inflammatory biomarkers in synovial fluid and an improvement in maximum mouth opening without significant adverse effects. Meta-analysis showed a significant increase in maximum mouth opening with the use of CS-GS (p = 0.19). No statistically significant differences were found in pain reduction compared to tramadol.
Conclusion: CS-GS is effective and safe in the symptomatic and functional improvement of patients with TMD.
期刊介绍：
Bulletin of Volcanology was founded in 1922, as Bulletin Volcanologique, and is the official journal of the International Association of Volcanology and Chemistry of the Earth’s Interior (IAVCEI). The Bulletin of Volcanology publishes papers on volcanoes, their products, their eruptive behavior, and their hazards. Papers aimed at understanding the deeper structure of volcanoes, and the evolution of magmatic systems using geochemical, petrological, and geophysical techniques are also published. Material is published in four sections: Review Articles; Research Articles; Short Scientific Communications; and a Forum that provides for discussion of controversial issues and for comment and reply on previously published Articles and Communications.
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