Comparison of hepatoprotective activity of Swertia chirayita and Andrographis paniculata plant of North–East India against CCl4 induced hepatotoxic rats

Abstract

Background

The aim of present study was to demonstrate and compare the hepatoprotective activity of ethanol extract of two well-known plants Swertia chirayita Buch-Ham and Andrographis paniculata (Burm.f.) Nees, in Swiss albino rats.

Method

The hepatotoxicity induced by single dose of CCl₄ dissolved in olive oil (1 ml/kg b.w.; p.o.) while vehicle control given food and water only. Vehicle as well as hepatotoxic rats were divided into groups (n = 6). Standard group treated with Silymarin (50 mg/kg b.w.; p.o.) daily for 16 days; and treated group received ethanol extract of plant A. paniculata and S. chirayita at the dose of 200 mg/kg b.w. p.o. daily for 16 days respectively.

Results

Ethanol extract of plant S. chirayita and A. paniculata, at a dose of 200 mg/kg body weight exhibited protective lowering effects of the serum enzyme levels SGPT, SGOT, GGTP and SALP to a significant extent. The pronounced activity observed in ethanol extract of A. Paniculata with dose of 200 mg/kg (b.w.) however decreases the elevated level of bilirubin, and lipid peroxidase (LPO). The decreased level of TP, GSH, SOD and CAT levels in CCl₄ induced hepatotoxic animal were significantly increase on treatment with ethanol extract of A. Paniculata and S. chirayita plant. The histopathological studies of liver were also supported hepatoprotective activity of A. paniculata.

Conclusion

Since results of biochemical studies conclude that the ethanol extract of A. Paniculata showed significant better hepatoprotective as compare to S. chirayita.