Osmund C. Enechi, Christian E. Odo, Onyedika N. Onyekwelu
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引用次数: 2
Abstract
Background and aim
The stem bark of Alstonia boonei is used in traditional medicine to treat or reduce inflammation and pain in Nigeria. In view of these, the effect of the ethanol extract of its stem bark on agar-induced leucocyte migration in rats as a mechanism of anti-inflammation was investigated.
Methods
The effect of the ethanol extract of the stem bark of A. boonei on agar-induced leucocyte migration in rats was evaluated using standard analytical method.
Results
The results showed significant (p < 0.05) inhibitions of leucocyte migrations in the rats administered 400, 800 and 1200 mg/kg body weight (b. w) compared to the leucocyte migration of the rats in the control group (5 ml/kg b. w of normal saline). The inhibitory effect of the extract was dose-dependent and comparable to that of the reference anti-inflammatory drug, indomethacin (0.3 mg/kg b. w).
Conclusion
The data indicate that the ethanol extract of the stem bark of A. boonei possesses remarkable inhibitory effect on leucocyte migration and therefore, justifies the traditional use of the stem bark of A. boonei as an anti-inflammatory agent.
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