CURCUMIN IN TREATMENT OF EXPERIMENTAL TRICHINOSIS

Heba Aboelela, S. Rashed, M. Nasr, O. Hammam, E. Elsayed, A. Ali
{"title":"CURCUMIN IN TREATMENT OF EXPERIMENTAL TRICHINOSIS","authors":"Heba Aboelela, S. Rashed, M. Nasr, O. Hammam, E. Elsayed, A. Ali","doi":"10.21608/jesp.2023.312133","DOIUrl":null,"url":null,"abstract":"Trichinella spiralis is one of the most widespread zoonotic parasitic nematodes in the world. There is an increasing interest in developing new safe and effective anthelminthic herbal drug against T. spiralis . This study assessed the effect of curcumin (bioactive compound of C. longa ) in treatment of T. spiralis infected mice compared with albendazole. Seventy-five albino mice were classified into four groups. GI: Non-infected control, GII: Infected non-treated control, GIII: Treated early 3 rd dpi by albendazole alone, curcumin alone, and combination of albendazole & curcumin, and GIV: Treated on 31 st dpi by the same drugs. Mice were sacrificed on the 7 th dpi for intestinal phase assessment and on the 49 th dpi for muscle assessment. Treatment efficiency was assessed by parasitological and histopathological examinations. The results showed a significant decrease in intestinal adults ' count in all treated groups compared to non-treated cont rolones. Reduction rates of the intestinal phase were 92.87% in albendazole & curcumin treated group followed by 87.58% in albendazole treated group and 62.93% in curcumin treated group. There was also significant decrease in muscle larvae count compared to positive control ones by reduction rates of 84.03%, 70.38% & 44.96% for albendazole &curcumin, albendazole alone and curcumin alone respectively. The histopathological results showed improvement in intestinal and muscular architecture in all treated groups compared to positive control one, particularly in combined albendazole & curcumin treated group.","PeriodicalId":17289,"journal":{"name":"Journal of the Egyptian Society of Parasitology","volume":"39 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the Egyptian Society of Parasitology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.21608/jesp.2023.312133","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Trichinella spiralis is one of the most widespread zoonotic parasitic nematodes in the world. There is an increasing interest in developing new safe and effective anthelminthic herbal drug against T. spiralis . This study assessed the effect of curcumin (bioactive compound of C. longa ) in treatment of T. spiralis infected mice compared with albendazole. Seventy-five albino mice were classified into four groups. GI: Non-infected control, GII: Infected non-treated control, GIII: Treated early 3 rd dpi by albendazole alone, curcumin alone, and combination of albendazole & curcumin, and GIV: Treated on 31 st dpi by the same drugs. Mice were sacrificed on the 7 th dpi for intestinal phase assessment and on the 49 th dpi for muscle assessment. Treatment efficiency was assessed by parasitological and histopathological examinations. The results showed a significant decrease in intestinal adults ' count in all treated groups compared to non-treated cont rolones. Reduction rates of the intestinal phase were 92.87% in albendazole & curcumin treated group followed by 87.58% in albendazole treated group and 62.93% in curcumin treated group. There was also significant decrease in muscle larvae count compared to positive control ones by reduction rates of 84.03%, 70.38% & 44.96% for albendazole &curcumin, albendazole alone and curcumin alone respectively. The histopathological results showed improvement in intestinal and muscular architecture in all treated groups compared to positive control one, particularly in combined albendazole & curcumin treated group.
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
姜黄素治疗实验性旋毛虫病
旋毛虫是世界上分布最广的人畜共患寄生虫之一。开发新的安全有效的抗螺旋体虫草药已成为人们日益关注的问题。本研究比较了姜黄素与阿苯达唑对螺旋体感染小鼠的治疗效果。将75只白化小鼠分为四组。GI:未感染对照组,GII:感染未治疗对照组,GIII:在第3个dpi早期单独使用阿苯达唑、姜黄素单独使用或阿苯达唑与姜黄素联合使用治疗,GIV:在第31个dpi时使用相同药物治疗。第7 dpi处死小鼠进行肠道期评估,第49 dpi处死小鼠进行肌肉期评估。通过寄生虫学和组织病理学检查评估治疗效果。结果显示,与未接受治疗的对照组相比,所有治疗组的肠道成虫数量都显著减少。阿苯达唑+姜黄素治疗组肠道期还原率为92.87%,阿苯达唑治疗组为87.58%,姜黄素治疗组为62.93%。与阳性对照相比,阿苯达唑+姜黄素组、单用阿苯达唑组和单用姜黄素组的肌肉幼虫数量分别减少了84.03%、70.38%和44.96%。组织病理学结果显示,与阳性对照组相比,所有治疗组的肠道和肌肉结构都有所改善,特别是阿苯达唑和姜黄素联合治疗组。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
THERAPEUTIC EFFICACY OF LACTOFERRIN LOADED ON NANO-PARTICLES IN TRICHINELLA SPIRALIS INFECTION IN MICE EFFECTS OF INTRAMUSCULAR INJECTION OF PLATELET-RICH PLASMA ON LARVAL BURDEN OF TRICHINELLA SPIRALIS IN EXPERIMENTALLY INFECTED MICE HUMAN LICE INFESTATION, DIAGNOSIS AND TREATMENT: A MINI-REVIEW COMPARISON BETWEEN GROWTH MAGNITUDE OF BLASTOCYSTIS GENOTYPES ISOLATED FROM GASTROINTESTINAL SYMPTOMATIC EGYPTIAN PATIENTS CAPILLARIA PHILIPPINENSIS IDENTIFIED IN DIARRHEIC PATIENTS FROM BENI-SUEF UNIVERSITY HOSPITALS, EGYPT
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1