Study of serum ferritin levels in various phases of dengue in pediatric dengue patients admitted in a tertiary hospital

Meghana N, Pradeep N
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引用次数: 1

Abstract

Background: Dengue is a cause of public health concern with case fatality rate of 1%. Ferritin is an acute-phase reactant which is produced in response to infection and inflammation. The aim of this study is to evaluate serum ferritin levels in various phases of dengue in pediatric dengue patients. Methods: A hospital-based, prospective, and observational study was done involving 30 dengue cases diagnosed by positive NS1 antigen or dengue specific serology (capture enzyme-linked immunosorbent assay). Serum ferritin was estimated by electrochemiluminescence in all three phases of dengue. Clinical and platelet count monitoring was done daily; respectively. All children classified as dengue with or without warning signs and severe dengue according to the World Health Organization guidelines on diagnosis treatment, prevention, and control of dengue, 2009. Results: Out of total of 30 children with mean age of the children were 7 years, and 61% were male who were majority. High serum ferritin levels were noted during critical phase. Eight children with dengue shock syndrome and one with acute respiratory distress syndrome were managed in intensive care unit as compared to non-severe dengue with statistically significant difference as p<0.05. Increase in serum ferritin is associated with severe thrombocytopenia. The mean hospital stay duration was found to be 5±3 days (mean±standard deviation). Conclusion: Serum ferritin levels taken on admission can serve as a reliable and cost-effective biomarker in the assessment and in predicting the severity of dengue fever. Serum ferritin levels may help in identifying an uncomplicated dengue illness, from that of patients who may require inpatient admission/intensive critical care.
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某三级医院收治的小儿登革热患者登革热各阶段血清铁蛋白水平的研究
背景:登革热是引起公共卫生关注的一种疾病,病死率为1%。铁蛋白是一种急性期反应物,是在感染和炎症反应中产生的。本研究的目的是评估小儿登革热患者不同阶段的血清铁蛋白水平。方法:一项以医院为基础的前瞻性观察性研究,涉及30例通过NS1抗原阳性或登革热特异性血清学(捕获酶联免疫吸附测定)诊断的登革热病例。用电化学发光法测定登革热三期患者血清铁蛋白。每日监测临床及血小板计数;分别。根据世界卫生组织2009年关于登革热诊断、治疗、预防和控制的指南,所有儿童均被归类为有或无警告迹象的登革热和严重登革热。结果:30例患儿中,平均年龄7岁,男性占61%,占多数。危急期血清铁蛋白水平升高。重症监护室治疗登革休克综合征患儿8例,急性呼吸窘迫综合征患儿1例,与非重症登革患儿比较,p<0.05,差异有统计学意义。血清铁蛋白升高与严重的血小板减少症有关。平均住院时间为5±3天(平均值±标准差)。结论:入院时血清铁蛋白水平可作为评估和预测登革热严重程度的可靠和经济的生物标志物。血清铁蛋白水平可能有助于从可能需要住院/重症监护的患者中识别无并发症的登革热疾病。
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