Multiple Genotypes of Avian Infectious Bronchitis Virus Circulating in Vietnam

Korean Journal of Poultry Science Pub Date : 2019-06-01 DOI:10.5536/kjps.2019.46.2.127

T. Le, H. Lee, V. Le, Kang-Seuk Choi

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引用次数: 6

Abstract

Three strains of infectious bronchitis viruses (IBVs), designated VNUA3, VNUA8 and VNUA11, were isolated from diseased/infected chickens in Hanoi, Thainguyen, and Haiphong provinces of Vietnam. These birds had received a live IBV vaccination but still suffered from infectious bronchitis. VNUA3, VNUA8 and VNUA11 harbor cleavage sites (RRTGR, HRRRR, and HRRKR, respectively) within the S protein. A BLASTN search revealed that the S gene of VNUA3, VNUA8, and VNUA11 showed the highest nucleotide identity with those of IBV strains CK/Italy/I2022/13, CK/CH/LHLJ/08-6, and GX-NN120084, respectively. Phylogenetic analyses based on the S gene nucleotide sequences revealed that VNUA3, VNUA8 and VNUA11 clustered with Q1-like, QX-like and TC07-2-like genotypes, respectively, and were closely related to reference IBV strains from China. However, the Vietnam IBVs showed high divergence from vaccine strains 4/91 and Ma5, which are used in the Vietnamese farms from which the isolates were obtained. Taken together, these results indicate that at least three genotypes of IBV are circulating among chickens in North Vietnam. This is the first report of the molecular epidemiology of IBV in Vietnam. (

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越南流行的禽传染性支气管炎病毒的多基因型

从越南河内、丹庆和海防三省病鸡中分离到3株传染性支气管炎病毒(ibv)，分别为VNUA3、VNUA8和VNUA11。这些鸟接受了IBV活疫苗接种，但仍然患有传染性支气管炎。VNUA3、VNUA8和VNUA11在S蛋白中含有裂解位点(分别为RRTGR、HRRRR和HRRKR)。BLASTN检索结果显示，VNUA3、VNUA8和VNUA11分别与IBV株CK/Italy/I2022/13、CK/CH/LHLJ/08-6和GX-NN120084的S基因核苷酸同源性最高。基于S基因核苷酸序列的系统进化分析显示，VNUA3、VNUA8和VNUA11分别为Q1-like、QX-like和TC07-2-like基因型聚类，与中国IBV参考株亲缘关系密切。然而，越南ibv与获得分离株的越南农场使用的疫苗株4/91和Ma5表现出高度差异。综上所述，这些结果表明至少有三种基因型的IBV在越南北部的鸡群中传播。这是越南首次报道IBV分子流行病学。（

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Korean Journal of Poultry Science

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