Teng Fei Zhang, Hai Tao Lv, Yue Ting Jin, Wen x Ting Jin, Hai Bo Wu, Qiu Sheng Li, Peng Xiang Liu, Zi Qiang Wu, Yao Zheng Zhang
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引用次数: 0
Abstract
: Cholangiocarcinoma (CCA) is a diverse group of malignant tumors originating from the bile duct and other sites in the biliary tree. Effective treatment methods for CCA are currently lacking. Therefore, understanding the genetic mechanisms and therapeutic targets is crucial for improving treatment outcomes and survival rates. This review focuses on the key roles of the phosphatidylinositol 3-kinase (PI3K) signaling pathway in CCA tumor initiation and progression. Potential therapeutic approaches based on this pathway were also discussed. Results showed increased activation of the PI3K/AKT pathway in CCA tissues and proteins like p85α, mTOR
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