Teng Fei Zhang, Hai Tao Lv, Yue Ting Jin, Wen x Ting Jin, Hai Bo Wu, Qiu Sheng Li, Peng Xiang Liu, Zi Qiang Wu, Yao Zheng Zhang
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引用次数: 0
Abstract
: Cholangiocarcinoma (CCA) is a diverse group of malignant tumors originating from the bile duct and other sites in the biliary tree. Effective treatment methods for CCA are currently lacking. Therefore, understanding the genetic mechanisms and therapeutic targets is crucial for improving treatment outcomes and survival rates. This review focuses on the key roles of the phosphatidylinositol 3-kinase (PI3K) signaling pathway in CCA tumor initiation and progression. Potential therapeutic approaches based on this pathway were also discussed. Results showed increased activation of the PI3K/AKT pathway in CCA tissues and proteins like p85α, mTOR
期刊介绍：
Earth Science Frontiers is a bimonthly Chinese academic journal co-sponsored by China University of Geosciences (Beijing) and Peking University. Academician Deng Jun has been the editor-in-chief since its founding in 1994. Each issue of the journal invites special editors to compile theme albums, supplemented by selected free submissions, to fully display the cutting-edge, innovative and basic research results in the field of earth sciences, and publish academic debate articles. With its academic influence and excellent performance, Earth Science Frontiers has won honors such as "China's Most Internationally Influential Academic Journal" and "One Hundred Outstanding Chinese Academic Journals", and has been selected into China's "Excellence Action Plan" project.
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