Drug forms of levothyroxine. Is there room for innovation in hypothyroidism treatment?

© Е.А. Колпакова, А.А. Вознесенская, Н.В. Фролкова, Е. А. Трошина, E. A. Kolpakova, A. A. Voznesenskaya, N. V. Frolkova, E. Troshina
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Abstract

Levothyroxine steadily maintains its position as the «gold standard» in the treatment of hypothyroidism. Despite the possibility of step-by-step tableted dose titration of levothyroxine, the results of many studies reliably point to the fact that a significant number of patients do not reach the target level of thyroid hormone. One of the main reasons for the therapy ineffectiveness is the inconvenience of levothyroxine sodium regimen for many patients, associated with the need to observe certain time intervals before meals and other medications. The above-mentioned factors have stimulated a number of studies aimed at developing new dosage forms with significant advantages in the pharmacokinetics and pharmacodynamics of drugs. The review provides the latest data on the new dosage forms of levothyroxine. Further large-scale clinical trials are needed for a more reasonable and widespread use of new dosage forms of levothyroxine in clinical practice.
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左甲状腺素的药物形式。甲状腺功能减退的治疗还有创新的空间吗?
左甲状腺素稳定地保持其作为治疗甲状腺功能减退的“金标准”的地位。尽管左甲状腺素有可能逐步片剂量滴定,但许多研究结果可靠地指出,相当多的患者甲状腺激素未达到目标水平。治疗无效的主要原因之一是左旋甲状腺素钠治疗方案对许多患者不方便,需要在饭前和其他药物治疗前观察一定的时间间隔。上述因素刺激了许多旨在开发在药物的药代动力学和药效学方面具有显著优势的新剂型的研究。本综述提供了关于左甲状腺素新剂型的最新数据。为了在临床实践中更合理、更广泛地使用新剂型的左甲状腺素,还需要进一步的大规模临床试验。
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