Che-Wei Huang, Yu-Jie Huang, Pei-Wen Yen, Hsiao-Ting Hsueh, Chia-Yi Lin, Min-Cheng Chen, C. Ho, Fu-Liang Yang, H. Tsai, H. Liao, Y. Juang, Chorng-Kuang Wang, Chih-Ting Lin, Shey-Shi Lu
{"title":"A fully integrated hepatitis B virus DNA detection SoC based on monolithic polysilicon nanowire CMOS process","authors":"Che-Wei Huang, Yu-Jie Huang, Pei-Wen Yen, Hsiao-Ting Hsueh, Chia-Yi Lin, Min-Cheng Chen, C. Ho, Fu-Liang Yang, H. Tsai, H. Liao, Y. Juang, Chorng-Kuang Wang, Chih-Ting Lin, Shey-Shi Lu","doi":"10.1109/VLSIC.2012.6243821","DOIUrl":null,"url":null,"abstract":"Polysilicon nanowire (poly-Si NW) based biosensor is integrated with the wireless acquisition circuits in a standard CMOS SoC for the first time. To improve detection quality, a chopper DDA-based analog front-end with features of low noise, high CMRR, and rail-to-rail input range is implemented. Additional temperature sensor is also included to compensate temperature drift of the biosensor. The results indicate that the detection limit is as low as 10fM. The capability to distinguish one base-pair mismatched DNAs is also demonstrated.","PeriodicalId":6347,"journal":{"name":"2012 Symposium on VLSI Circuits (VLSIC)","volume":"78 2 1","pages":"124-125"},"PeriodicalIF":0.0000,"publicationDate":"2012-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"11","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"2012 Symposium on VLSI Circuits (VLSIC)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1109/VLSIC.2012.6243821","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 11
Abstract
Polysilicon nanowire (poly-Si NW) based biosensor is integrated with the wireless acquisition circuits in a standard CMOS SoC for the first time. To improve detection quality, a chopper DDA-based analog front-end with features of low noise, high CMRR, and rail-to-rail input range is implemented. Additional temperature sensor is also included to compensate temperature drift of the biosensor. The results indicate that the detection limit is as low as 10fM. The capability to distinguish one base-pair mismatched DNAs is also demonstrated.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
