A Study of the Conversion of Aflatoxin B1 by Treatment with Sodium Hydrogen Sulfite

Journal of The Food Hygienic Society of Japan (shokuhin Eiseigaku Zasshi) Pub Date : 1999-12-05 DOI:10.3358/SHOKUEISHI.40.6_431

S. Tabata, H. Kamimura, M. Nishijima, S. Tanabe

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引用次数: 3

Abstract

In the manufacturing process for commercial cornstarch, corn is soaked in an aqueous solution of sodium hydrogen sulfite (NaHSO3), which reduces aflatoxin (AF) B1. The conversion product from AFB1 by treatment with NaHSO3 under similar conditions to those of the manufacturing process for cornstarch was investigated. After treatment of AFB1 standard, the conversion product (compound I) was isolated and identified by FAB-MS and NMR. A sulfo group was added to the double bond of bisfuran ring of AFB1. We applied the treatment to artificially and naturally AF-contaminated corn and confirmed that compound I was produced from AFB1. In the case of artificially AF-contaminated corn, 915ng of AFB1 was reduced, and 506ng of compound I was produced from 2, 000ng of AFB1 by NaHSO3. It was suggested that the conversion product is actually produced from AFB1 in the manufacturing process for commercial cornstarch. Effective detoxification is expected, because compound I is a watersoluble compound, and lacks the double bond in the bisfuran ring, which is activated to react with DNA.

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亚硫酸氢钠处理黄曲霉毒素B1转化的研究

在商业玉米淀粉的制造过程中，玉米浸泡在亚硫酸氢钠(NaHSO3)的水溶液中，以减少黄曲霉毒素(AF) B1。研究了在与玉米淀粉生产工艺相似的条件下，用NaHSO3处理AFB1的转化产物。经AFB1标准品处理后，分离得到转化产物(化合物I)，并通过FAB-MS和NMR进行鉴定。在AFB1双呋喃环的双键上加入了一个亚砜基团。我们对人工和天然AFB1污染的玉米进行了处理，确认化合物I是从AFB1中产生的。在人工污染AFB1的玉米中，NaHSO3还原了915ng AFB1，并从2000 ng AFB1中产生506ng化合物I。结果表明，该转化产物实际上是由AFB1在商品玉米淀粉的生产过程中产生的。有效的解毒是预期的，因为化合物I是一种水溶性化合物，并且在双呋喃环中缺乏双键，而双键被激活以与DNA反应。

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Journal of The Food Hygienic Society of Japan (shokuhin Eiseigaku Zasshi)

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