Synthesis, characterization and antimicrobial activity of pyrimidine based derivatives

Abstract

Aim

Pyrimidine and their derivatives play the vital role in the field of drugs and agricultural chemicals. In recent decades, a large no. of pharmacological studies has been done on Pyrimidine and their derivatives. But still more research is required in order to necessity of biological compounds. “The Chalcone is an aromatic compound that forms the central core for different necessity of biological compounds. The Chalcone is synthesized by an aldol, condensation of 4-methoxy acetophenone with m-phenoxy benzaldehydes in the presence of a catalyst that is treated with thiourea to provide Pyrimidine. The Pyrimidine treated with substituted N-1,3-benzothiazole-2-yl-2-chloro amide gives a compound”.

Methods

Elemental analysis, IR, H NMR, C NMR melting point, Thin layer chromatography (TLC) plates (silica gel G) is used to determine the purity of the compounds.

Result

Antimicrobial activity: All the synthesized compounds screened against four different strains, viz two Gram +ve bacteria (Staphylococcus aureus & Streptococcus pyogenes) and two Gram −ve bacteria (Escherichia coli & Pseudomonas aeruginosa), analyzed with standard drugs ampicillin, chloramphenicol, ciprofloxacin, & norfloxacin. Antifungal activities: All the synthesized compounds screened against Candida albicans, and Aspergillus niger organisms, analyzed with standard drugs nystatin and griseofulvin.

Conclusion

In this paper we focused on the reactions, synthesis, spectral analysis and Microbial activities of Pyrimidine based benzothiazole derivatives. The method gives excellent than previously reported literature. Some of the compounds were effective as antimicrobial and antifungal agents.