A. M. Inshakova, E. Darnotuk, A. Shipelova, N. Shastina, O. Baranova, A. Chekanov, K. Kazarinov, E. Solovieva, A. Fedin
{"title":"NANODISPERSIONS OF LIPOIC ACID: PRODUCTION AND STUDY OF INFLUENCE ON FUNCTIONAL ACTIVITY OF PLATELETS","authors":"A. M. Inshakova, E. Darnotuk, A. Shipelova, N. Shastina, O. Baranova, A. Chekanov, K. Kazarinov, E. Solovieva, A. Fedin","doi":"10.37747/2312-640x-2021-19-101-104","DOIUrl":null,"url":null,"abstract":"Various nanodispersions (liposomes and nanoemulsions) with lipoic acid (LA) with size of particles 50-250 nm were obtained and characterized by 80±10% encapsulation efficiency (EI) of LA into NPs, its slow release from nanoconstructions, and possessing stability during long-term storage at room temperature. It was revealed that liposomes and LA NPs inhibit platelet aggregation caused by arachidonic acid, and the mechanism of antiplatelet action was proposed.","PeriodicalId":13077,"journal":{"name":"http://eng.biomos.ru/conference/articles.htm","volume":"98 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"http://eng.biomos.ru/conference/articles.htm","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.37747/2312-640x-2021-19-101-104","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Various nanodispersions (liposomes and nanoemulsions) with lipoic acid (LA) with size of particles 50-250 nm were obtained and characterized by 80±10% encapsulation efficiency (EI) of LA into NPs, its slow release from nanoconstructions, and possessing stability during long-term storage at room temperature. It was revealed that liposomes and LA NPs inhibit platelet aggregation caused by arachidonic acid, and the mechanism of antiplatelet action was proposed.
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